Multichannel Sonocatalysis Amplifiers Target IDH1‐Mutated Tumor Plasticity and Attenuate Ros Tolerance to Repress Malignant Cholangiocarcinoma

Wang, Duo; Zhu, Xiaoqi; Wang, Xiaobo; Wang, Qin; Yan, Kai; Zeng, Gu-Qing; Qiu, Guanhua; Rong, Jian; Lin, Xia; Chen, Jie; Yang, Qiaoling; Wen, Qiuyuan; Liu, Junjie; Zhang, Kun; Liu, Yan

doi:10.1002/adfm.202303869

Cited by 13 publications

(2 citation statements)

References 55 publications

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“…Moreover, FSC + US significantly reduced the GSH compared with other groups, revealing the efficient GSH depletion ability. The ratio of GSH/GSSG is considered a powerful index of oxidative stress ( Wang D. et al, 2023 ; Liu et al, 2023 ). The results showed that in the Fe 3 O 4 @SiO 2 and FSC treatment groups, the GSH/GSSG ratio was slightly varied, while it was greatly decreased in FSC + US group ( Figure 4D ), altogether confirming the superiority of FSC sonodynamic therapy.…”

Section: Resultsmentioning

confidence: 99%

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Zhou,

Cao,

Jiang

et al. 2024

Front. Bioeng. Biotechnol.

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Ovarian cancer presents a substantial challenge due to its high mortality and recurrence rates among gynecological tumors. Existing clinical chemotherapy treatments are notably limited by drug resistance and systemic toxic side effects caused by off target drugs. Sonodynamic therapy (SDT) has emerged as a promising approach in cancer treatment, motivating researchers to explore synergistic combinations with other therapies for enhanced efficacy. In this study, we developed magnetic sonodynamic nanorobot (Fe3O4@SiO2-Ce6, FSC) by applying a SiO2 coating onto Fe3O4 nanoparticle, followed by coupling with the sonosensitizer Ce6. The magnetic FSC nanorobot collectives could gather at fixed point and actively move to target site regulated by magnetic field. In vitro experiments revealed that the magnetic FSC nanorobot collectives enabled directional navigation to the tumor cell area under guidance. Furthermore, under low-intensity ultrasonic stimulation, FSC nanorobot collectives mediated sonodynamic therapy exhibited remarkable anti-tumor performance. These findings suggest that magnetically actuated sonodynamic nanorobot collectives hold promising potential for application in target cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Zhou,

Cao,

Jiang

et al. 2024

Front. Bioeng. Biotechnol.

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“…With advancements in scientific and technological progress, chemodynamical therapy (CDT) has emerged as a viable alternative for tumor treatment in recent years [17]. CDT operates by converting intracellular H 2 O 2 into •OH using the iron Fenton reaction, leading to lethal toxicity specifically targeting tumor cells [18,19]. Consequently, the current research primarily concentrates on the development of nanocarriers and nano catalysts capable of transporting Fenton catalysts or metal ions [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Cell-Membrane-Coated Metal–Organic Framework Nanocarrier Combining Chemodynamic Therapy for the Inhibition of Hepatocellular Carcinoma Proliferation

Xie,

Xiao,

et al. 2024

Pharmaceutics

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Chemodynamic therapy (CDT) employs hydrogen peroxide (H2O2) within the tumor microenvironment (TME) to initiate the Fenton reaction and catalyze the generation of hydroxyl radicals (·OH) for targeted therapy. Metal ion-based nanomaterials have garnered significant attention as catalysts due to their potent anti-tumor effects. Hypoxia in the TME is often associated with cancer cell development and metastasis, with HIF-1α being a pivotal factor in hypoxia adaptation. In this study, an organic framework called MIL-101 (Fe) was designed and synthesized to facilitate H2O2-induced ·OH production while also serving as a carrier for the HIF-1α inhibitor Acriflavine (ACF). A biomimetic nanomedical drug delivery system named MIL-101/ACF@CCM was constructed by encapsulating liver cancer cell membranes onto the framework. This delivery system utilized the homologous targeting of tumor cell membranes to transport ACF, inhibiting HIF-1α expression, alleviating tumor hypoxia, and catalyzing ·OH production for effective tumor eradication. Both in vivo and in vitro experiments confirmed that combining ACF with chemotherapy achieved remarkable tumor inhibition by enhancing ROS production and suppressing HIF-1α expression.

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Dual‐Functional Artificial Peroxidases with Ferriporphyrin Centers for Amplifying Tumor Immunotherapies via Immunogenic Cell Death

Wang,

Li,

Zhao

et al. 2023

Adv Funct Materials

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Constructing highly effective sonosensitizers that integrate tumor microenvironment (TME)‐adaptive and ultrasound (US)‐controllable production of reactive oxygen species (ROS) to amplify tumor immunotherapies is extremely desirable but remains challenging. Here, inspired by the coordination structure and biocatalytic effects of Fe‐based peroxidase, a dual‐functional artificial peroxidase is synthesized with ferriporphyrin networks (FePorNW‐DAP) to serve a TME‐adaptive and US‐controllable ROS‐generator for amplifying tumor immunotherapies in breast cancer via immunogenic cell death. Owing to the structural advantages of the ferriporphyrin‐based large d–π‐conjugated networks with the monatomic Fe─N4 coordination center, moderate interaction with H2O2, and decreased bandgap, the FePorNW‐DAP displays efficient dual‐functional ROS production capabilities to combat tumor cells and amplify the tumor immunotherapies, 1) utilize locally produced H2O2 in the TME to catalytically generate potent •OH and other ROS species; simultaneously, 2) external US irradiation can further boost the generation of •OH and 1O2. This work provides not only critical evidence that the proposed dual‐functional artificial peroxidases can induce a strong antitumor immune response and immune memory but also offers essential guidance for creating a high‐performance and biocompatible strategy to regulate the immunosuppression TME and enhance the antitumor immune responses of breast cancer.

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Multichannel Sonocatalysis Amplifiers Target IDH1‐Mutated Tumor Plasticity and Attenuate Ros Tolerance to Repress Malignant Cholangiocarcinoma

Cited by 13 publications

References 55 publications

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Cell-Membrane-Coated Metal–Organic Framework Nanocarrier Combining Chemodynamic Therapy for the Inhibition of Hepatocellular Carcinoma Proliferation

Dual‐Functional Artificial Peroxidases with Ferriporphyrin Centers for Amplifying Tumor Immunotherapies via Immunogenic Cell Death

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