Multicentric Study on Paired Filtration Dialysis as a Short, Highly Efficient Dialysis Technique

Abstract

Paired filtration dialysis (two-chamber haemodiafiltration) was evaluated as a short, highly efficient renal replacement therapy in 35 uraemic subjects belonging to three different dialysis centres. The study period was 1 year. Patients were divided into two groups according to their body-weight and drinking habits. The smaller patients underwent 150-min dialysis sessions three times weekly. The larger patients underwent 3-h treatments thrice weekly. The treatment was adequate in all patients according to the KT/V criteria of adequacy. The intradialytic symptomatology was remarkably low and the treatments were well tolerated in all patients. The study confirms the reliability of paired filtration dialysis as a short dialysis technique. In some patients 150 min may be insufficient to achieve an adequate dialysis efficiency and 180 min may be required for the majority of the population.

Hemodiafiltration with On-Line Endogenous Reinfusion

“…Biocompatibility, absence of backfiltration and clinical stability are also advantages of the technique [7][8][9][10]. PFD was also effective in reducing ß 2 -microglobulin between dialyses and had a long-term effect of lowering ß 2 -microglobulin before dialysis.…”

Adsorption in Extracorporeal Blood Purification: How to Enhance Solutes Removal Beyond Diffusion and Convection

“…Therefore, this technique physically separates convection from diffusion, thus leading to two main results: a) the continuous availability of pure uf during the whole duration of the session; b) the absence of dialysate backfiltration. The method was called Paired Filtration Dialysis (PFD) [figure 3], and his efficiency and tolerance have been proven [11].…”

“…The potential of non-coated carbon sorbent to activate the contact phase [24,25], lead to switch the carbon cartridge to a hydrophobic styrenicdivinylbenzene resin (40mL). This has the potential advantage of a high affinity for several uremic toxins and middle molecules such as β2-microglobulin, homocystein, angiogenin, PTH, and several chemokines and cytokines [26,27].…”

Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice

“…Likewise, as for other convective treatments, simultaneous but separate convection of PFD permitted higher depurative outcomes than standard HD mode, and even allowed treatment times to be reduced (Vanholder et al, 1991). Dialysis times could be reduced to as little as 150 minutes per session in patients with a body weight of < 61 kg without compromising dialytic tolerance and efficiency (Botella et al, 1991). PFD also achieves dialytic efficiencies comparable with HDF despite significantly lower filtration rates (40 versus 75 ml/min, respectively) (Bufano et al, 1991), which is primarily due to minimal interference between diffusion and convection.…”