Multicentric Squamous Odontogenic Tumor: A Case Report and Review of the Literature

Abstract

Squamous odontogenic tumor (SOT) is a rare benign epithelial odontogenic neoplasm of the jaws. Both intraosseous and peripheral SOTs have been described in the English language literature. While most intraosseous SOTs occur as solitary lesions, a multicentric variant has also been previously described. Although the radiographic and microscopic features are identical for both solitary and multicentric clinical presentations, there are three significant differences between them. More specifically, multicentric SOT presents at an earlier age (third decade of life), has a slightly higher male to female ratio than the solitary type and has a marked predilection for African-Americans. Here we document the eighth reported case of multicentric SOT, which was diagnosed in a 43-year-old AfricanAmerican male. In addition, we feature focal sebaceous metaplasia, a heretofore unknown microscopic feature of SOT. Clinical, radiological, and histopathological findings are discussed. The differential diagnosis, biological behavior and management modalities for SOT are also addressed.

Maxillary dentigerous cyst showing squamous odontogenic tumor-like proliferation: surgical approach and literature review

“…Peripheral SOTs are extremely rare, and only eight cases have been reported, with the maxilla and mandible being equally affected. 2,12 Women were affected more frequently than men (ratio 3:1), with a mean age of 45 years. 3,4 Interestingly, tooth displacement in one case of peripheral SOT and six cases of SOT-LPOC have been reported.…”

“…3 Surgery is the treatment of choice for peripheral SOT and the prognosis is good. However, one case reported recurrence after 156 months of follow-up, [2][3][4]12 and close monitoring of these lesions is recommended. It is important to emphasize that microscopically SOT-LP can mimic a neoplasm.…”

“…Squamous odontogenic tumor (SOT) is a rare benign neoplasm histologically characterized by islands of well-differentiated squamous epithelium supported by a fibrous stroma. 1,2 To date, approximately 110 cases of SOT have been reported, with the vast majority (n=102) representing central lesions that are radiographically characterized as triangular radiolucent unilocular lesions. In contrast, peripheral SOT does not show radiographic alterations, but can eventually cause loss of the underlying bone.…”

Squamous odontogenic tumor and squamous odontogenic tumor-like proliferations in odontogenic cysts: An updated analysis of 170 cases reported in the literature

“…These include, for example, Simon et al (2002) (Baden et al, 1993;Elmuradi et al, 2016;Hopper et al, 1980;McNeill et al, 1980;Mills et al, 1986;Norris et al, 1984;Pullon et al, 1975), and there was one report describing multicentric disease in three siblings (Leider et al, 1989). The mean age of the patients was 34.8±14.5 and 45.4±23.0 for central and peripheral lesions, respectively.…”

Squamous Odontogenic Tumor of Posterior Maxilla-A Report of a New Unusual Case & Literature Review

“…The WHO classifies it as a benign epithelial odontogenic tumor, with only approximately 60 occurrences known. It was initially identified by Pullon et al in 1975 [1,2,3].…”