Multicentric reticulohistiocytosis with salivary gland involvement and pericardial effusion

Furey, Nancy; Mauro, Jose Di; Eng, Ana M.; Shaw, John M.

doi:10.1016/s0190-9622(83)70080-0

Cited by 29 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Male172 Male152 2Time before (-) [7]. Other modalities including XRT, intralesional injection of triamcinolone, thyroid hormones, and chloroquine offered no significant improvement.…”

Section: Male165mentioning

confidence: 99%

Multicentric reticulohistiocytosis and cancer: A case report and review of the literature

Nunnink

Krusinski

Yates

1985

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

Multicentric reticulohistiocytosis (MR) is a syndrome characterized by papulonodular skin lesions, a debilitating polyarthritis, and characteristic histologic findings. It is a rare disorder with only 82 cases reported. Twenty-eight percent had an associated neoplasm. Hematologic malignancies (four) and neoplasms arising from the breast (four), cervix (three), stomach (three), ovary (two), colon (two), lung (one), pleura (one), and from an unknown source (two) were all seen associated with MR. Eleven cases (including our own) were available for review. The papulonodular skin involvement was the initial manifestation (alone or concurrent with the polyarthritis) in 90% of our cases. The diagnosis of MR preceded that of the associated neoplasm in 73% of the cases. A case report is presented illustrating the relapse of MR before the clinical relapse of the associated tumor, and the response of both the tumor and MR to combination chemotherapy with cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone when prednisone and aspirin alone failed to relieve the symptoms of MR. Steroids were not beneficial in the patients reviewed. The best management of MR associated with a neoplasm is the best management of the primary neoplasm. Cytotoxic chemotherapy including cyclophosphamide should be considered if there is progression of the MR in order to control the symptoms of MR and prevent a progressive debilitating arthritis.

show abstract

“…Male172 Male152 2Time before (-) [7]. Other modalities including XRT, intralesional injection of triamcinolone, thyroid hormones, and chloroquine offered no significant improvement.…”

Section: Male165mentioning

confidence: 99%

Multicentric reticulohistiocytosis and cancer: A case report and review of the literature

Nunnink

Krusinski

Yates

1985

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

show abstract

“…Isotope scanning may be helpful in detecting occult systemic disease as gallium concentrates in these granulomatous deposits." 12 The cardiopulmonary complications of multicentric reticulohistiocytosis are rare and, as far as we are aware, this is the first report to describe extensive myocardial infiltration with this disease. Magnetic resonance imaging provided a sensitive and non-invasive method of monitoring this manifestation of the disease.…”

Section: Discussionmentioning

confidence: 79%

Multicentric reticulohistiocytosis with arthritis and cardiac infiltration: regression following treatment for underlying malignancy.

Lambert

Nuki

1992

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

The case is reported of a 63 year old man presenting with a rapidly destructive symmetrical polyarthritis and widespread papular nodular skin lesions, confirmed by a biopsy to be due to multicentric reticulohistiocytosis. Biventricular cardiac failure developed secondary to extensive myocardial infiltration with multicentric reticulohistiocytosis, a complication of this disease which has not previously been reported. The joint, skin, and cardiac manifestations of multicentric reticulohistiocytosis substantially regressed following resection of an associated squamous cell carcinoma. This report adds to the small amount of published work which suggests that multicentric reticulohistiocytosis can be a paraneoplastic disease that may respond to treatment directed at the underlying tumour.Multicentric reticulohistiocytosis is an uncommon disease of unknown aetiology sufficiently similar in its presentation to rheumatoid arthritis for it often to be initially mistaken as such. Although the joints and skin are the most commonly affected sites, multicentric reticulohistiocytosis may become a systemic disease with a poor prognosis. ' 2 contained periodic acid-Schiff positive material typical of this disease. The synovial fluid aspirate contained polymorphs, a few macrophages and lymphocytes, but there were no specific features of multicentric reticulohistiocytosis.The patient was initially treated symptomatically with rest, non-steroidal anti-inflammatory drugs (NSAIDs) and intra-articular steroids. The synovitis persisted, however, and cyclophosphamide (15 mg/kg/month) was given by intermittent intravenous infusion. There was some improvement in joint symptoms and synovitis after two infusions but the skin lesions remained static.Three months later the patient presented with dyspnoea at rest and signs of acute biventricular cardiac failure. Flexor tenosynovitis with deformities of the fingers had developed. The skin disease had progressed with the development of several larger nodules which were freely mobile within the subcutaneous tissue over the extensor aspect of his forearms and hands (fig 1) Case report A 63 year old previously healthy man presented with a three month history of polyarthralgia and morning stiffness affecting the hands, wrists, and knees together with an extensive painless, pruritic rash. Examination showed synovitis, bilateral knee effusions, and olecranon bursitis. Crops of red and brown papules 1-5 mm in diameter were present over the chest and abdomen. Xanthelasmata were noted but there were no other cutaneous features of hyperlipidaemia and the examination was otherwise normal.The erythrocyte sedimentation rate was increased at 43 mm in the first hour but the full blood count, plasma urea and electrolytes, liver function tests, fasting lipids, immunoglobulins, and rheumatoid factor were all normal. Hand radiographs showed soft tissue swelling, periarticular osteoporosis, and loss of articular cartilage of the proximal and distal interphalangeal joints. The diagnosis of multicentric ret...

show abstract

“…It primarily affects skin, mucous membrane, and joints. Systemic involvement of the disease secondary to histiocytic and multinucleated giant cell infiltration has been reported 1–3 . We now describe one case of MRH in which there were rheumatoid arthritis‐like symptoms, multiple types of cutaneous lesions, and widespread systemic involvement.…”

Section: Reportmentioning

confidence: 99%

Multicentric reticulohistiocytosis with generalized systemic involvement

Liu

Fang

2004

Clin Exp Dermatol

View full text Add to dashboard Cite

We describe a 33-year-old woman with a 2-year history of rheumatoid arthritis-like joint changes and a 1-year history of papulonodules on the fingers, ears, oral mucosa, forearm, elbows and thighs, and erythematous plaques on the buttocks. Six months after the onset of the cutaneous lesions she had dyspnoea, 3 months later she developed a husky sound. Biopsies from the nodules on the ear and left forearm revealed multinucleated giant cells with eosinophilic 'ground-glass' cytoplasm. Bronchoscopy revealed that there were nodules in the bronchus. A biopsy taken from a nodule from the bronchus was consistent with multicentric reticulohistiocytosis. Fibrostic laryngoscopy showed a mass 1.5 x 2.0 cm(2) in size on the left aryepiglottic fold and posterior commissure. Magnetic resonance imaging revealed a large pleural effusion and pericardiac effusion. Ultrasound revealed splenomegaly and peritoneal fluid. Combination therapy with prednisone, cyclophosphamide and methotrexate significantly improved cutaneous and joint symptoms. The huge cutaneous erythematous plaques and the generalized systemic involvement make this case interesting.

show abstract

Multicentric reticulohistiocytosis with salivary gland involvement and pericardial effusion

Cited by 29 publications

References 22 publications

Multicentric reticulohistiocytosis and cancer: A case report and review of the literature

Multicentric reticulohistiocytosis and cancer: A case report and review of the literature

Multicentric reticulohistiocytosis with arthritis and cardiac infiltration: regression following treatment for underlying malignancy.

Multicentric reticulohistiocytosis with generalized systemic involvement

Contact Info

Product

Resources

About