Multicentric reticulohistiocytosis masquerading as cutaneous connective tissue disease

Fronek, Lisa F; Bindernagel, Richard; Segars, Kelly; Miller, Richard A.

doi:10.5070/d3273052766

Cited by 2 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients typically have symmetric distal interphalangeal joint involvement along with shoulder, elbow, wrists, hip, knee, and feet arthritis. The bony erosions secondary to MRH are rapidly progressive, ultimately resulting in a condition called arthritis mutilans, observed in 45% of patients [ 7 ]. Skin nodules of MRH have a characteristic coral bead appearance and are more often observed around the ungual region and may also be observed on the mucosa, face, arms, and torso.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, multinucleated giant cells and histiocytes are seen with eosinophilic ground glass cytoplasm. These cells stain positive for periodic acid-Schiff (PAS), CD163, HAM56, and CD68 and negative for Langerhans markers such as S-100, CD1a, CD19, and CD20 [ 7 , 8 ]. Recent studies have demonstrated positive Mac387, vimentin, CD43, CD45, and lysozyme in a few patients [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multicentric Reticulohistiocytosis Presenting As Acute Pericarditis With Moderate-Sized Pericardial Effusion: A Case Report and Review of Multicentric Reticulohistiocytosis Treatment

Mandyam¹,

Onteddu²,

R³

et al. 2023

Cureus

View full text Add to dashboard Cite

Multicentric reticulohistiocytosis (MRH) is a rare, class IIb non-Langerhans cell histiocytosis associated with skin and joint involvement. It is more prevalent (80%) in Caucasian females in their fifth to sixth decade of life. Patients usually demonstrate symptoms and signs of symmetric polyarthritis and papulonodular cutaneous lesions. In addition to skin and joints, multiple organs can be involved, such as the lung (pleural effusion, interstitial fibrosis, hilar lymphadenopathy), heart (pericardial effusion, myocarditis), gastrointestinal system, and urogenital system (genital tract and kidney). Pericardial involvement is a rare manifestation, and around three cases have been reported in the literature so far. Our case report is a valuable contribution to the literature, which aids clinicians in contemplating MRH as one of the differentials among patients presenting with pericardial effusion. We described the characteristics of MRH along with its differentiating features from other autoimmune conditions and management.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multicentric Reticulohistiocytosis Presenting As Acute Pericarditis With Moderate-Sized Pericardial Effusion: A Case Report and Review of Multicentric Reticulohistiocytosis Treatment

Mandyam¹,

Onteddu²,

R³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…La reticulohistiocitosis multicéntrica es una enfermedad inflamatoria, una histiocitosis de células no Langerhans, poco frecuente y de etiología desconocida [1][2][3][4][5][6]. Sólo se han descrito aproximadamente 300 casos en la literatura [4].…”

Section: Introductionunclassified

“…Sólo se han descrito aproximadamente 300 casos en la literatura [4]. La enfermedad afecta predominantemente a la piel y las articulaciones, pero es posible la afectación visceral [3][4][5][6][7]. Compromete mayormente a mujeres en la quinta y sexta década de la vida con una relación mujer-hombre de 3 a 1 [4][5][6].…”

Section: Introductionunclassified

See 1 more Smart Citation

Multicentric reticulohistiocytosis revealing a ductal breast cancer in situ: A case report with dermoscopic and histopathological findings

Palma Peña,

Neely Erdos,

Buchroithner Haase

et al. 2024

Medwave

View full text Add to dashboard Cite

Multicentric reticulohistiocytosis is a rare non-Langerhans cell histiocytosis of unknown etiology. It is classified as multicentric because of multisystem involvement. The disease predominantly affects the skin and joints, but visceral involvement is possible. Multiple erythematous-brownish, pruritic nodules and papules on the face, hands, neck, and trunk are characteristic. It is associated with autoimmune diseases, or malignant neoplasms are seen in 20% to 30% of patients with multicentric reticulohistiocytosis. The diagnosis is based on histopathology of affected tissues. As it is an underreported disease, there is no standardized treatment. A case of multicentric reticulohistiocytosis is reported as a paraneoplastic manifestation of ductal breast cancer, being successfully treated with no recurrence after two years of follow-up. Few cases of multicentric reticulohistiocytosis associated with breast cancer have been reported in the literature.

show abstract

Multicentric reticulohistiocytosis masquerading as cutaneous connective tissue disease

Cited by 2 publications

References 10 publications

Multicentric Reticulohistiocytosis Presenting As Acute Pericarditis With Moderate-Sized Pericardial Effusion: A Case Report and Review of Multicentric Reticulohistiocytosis Treatment

Multicentric Reticulohistiocytosis Presenting As Acute Pericarditis With Moderate-Sized Pericardial Effusion: A Case Report and Review of Multicentric Reticulohistiocytosis Treatment

Multicentric reticulohistiocytosis revealing a ductal breast cancer in situ: A case report with dermoscopic and histopathological findings

Contact Info

Product

Resources

About