Multicentric lymphosarcoma with lymphoblastic leukaemia in a young horse

Equine lymphoma

“…Liver, spleen, intestine, kidney and bone marrow (leukaemic lymphoma) are the organs most commonly affected, but lymphoma of the upper airway, central nervous system, heart, adrenal glands, reproductive organs and eye have also been reported (Madewell et al . 1982; Allen et al . 1984; Browning 1986; Staempfli et al .…”

“…Multicentric lymphoma, the most common form of equine lymphoma, is characterised by widespread involvement of lymph nodes, peripheral and/or internal, and a variety of organs most likely through distribution of neoplastic lymphocytes via lymphatic circulation (Neufeld 1973;van den Hoven and Franken 1983;Savage 1998;McClure 2000;Knottenbelt 2003;Schneider 2003;Meyer et al 2006;Munoz et al 2009). Liver, spleen, intestine, kidney and bone marrow (leukaemic lymphoma) are the organs most commonly affected, but lymphoma of the upper airway, central nervous system, heart, adrenal glands, reproductive organs and eye have also been reported (Madewell et al 1982;Allen et al 1984;Browning 1986;Staempfli et al 1988;Murphy et al 1989;Held et al 1992;Freeman et al 1997;Labelle and De Cock 2005;Stoppini et al 2005;Germann et al 2008;Morrison et al 2008). Clinical signs of multicentric lymphoma reflect the function of organs involved, thus a multitude of symptoms may be present at one time, but horses with the multicentric form of lymphoma commonly have weight loss, oedema of the ventral body wall, elevated temperature, pulse and respiration, and enlarged lymph nodes (lymphadenopathy) (Neufeld 1973;van den Hoven and Franken 1983;Savage 1998;McClure 2000;Knottenbelt 2003;Schneider 2003;Meyer et al 2006;Munoz et al 2009).…”

Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B‐cell lymphoma

“…Mono‐ and polyclonal gammopathy are frequently described in horses with various subtypes of lymphoma of B‐ and T‐cell origin . Protein electrophoresis revealed a serum monoclonal gammopathy, and a urine monoclonal light chain gammopathy, which can be associated with B‐cell lymphoid neoplasia.…”

Clinical manifestations of neoplasia

“…Iron deficiency is usually associated with chronic blood loss, and in adult horses this i s often due to loss from the (Roberts 1977;Brumbaugh et a/. 1982;Allen et a/. 1984;Burkhardt et a/.…”