Multicentric Giant Cell Tumor of Bone: A Case Report and Review of the Literature

Taylor, Kenneth F.; Yingsakmongkol, Wicharn; Conard, Katrina; Stanton, Robert P.

doi:10.1097/01.blo.0000063784.32430.b0

Cited by 31 publications

(22 citation statements)

References 15 publications

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“…In our series as well as in the former literature approximately 1% of GCTB present as multiple synchronous or metachronous lesions (Haskell et al 2003;Hindman et al 1994;Hoch et al 2006;Leggon et al 2004;Taraporvala et al 1997;Taylor et al 2003). As reported by several authors, patients with multicentric GCTB are likely to be younger than those with a solitary lesion (Hindman et al 1994;Hoch et al 2006).…”

Section: Multifocal Gctbsupporting

confidence: 53%

Giant cell tumor of bone: treatment and outcome of 214 cases

Balke

Schremper

Gebert

et al. 2008

J Cancer Res Clin Oncol

373

414

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The combination of all adjuncts (PMMA, burring, H(2)O(2) - n = 42) reduces the likelihood of recurrence by the factor 28.2 compared to curettage only and therefore should be recommended as a standard treatment. If the tumor reaches close to the articulating surface a subchondral bone graft (n = 42) can be performed without risking a higher recurrence rate. We add seven cases of pulmonary metastases and two cases of multicentricity to the literature. Bisphosphonates and interferon alpha may have a beneficial effect.

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Section: Multifocal Gctbsupporting

confidence: 53%

Giant cell tumor of bone: treatment and outcome of 214 cases

Balke

Schremper

Gebert

et al. 2008

J Cancer Res Clin Oncol

373

414

View full text Add to dashboard Cite

show abstract

“…[67] Half-yearly screening by either bone scan or skeletal survey is recommended for GCTs at unusual sites or those diagnosed with multicentric involvement. Our literature review [Table 1] showed that this protocol should be followed for at least five years, as most cases develop multicentricity and additional lesions within this period.…”

Section: Discussionmentioning

confidence: 99%

Multicentric giant cell tumor involving the same foot: A case report and review of literature

Dhillon¹,

A²,

Virk³

et al. 2007

Indian J Orthop

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Multicentric giant cell tumour (GCT) is extremely rare; no case has been previously reported where two lesions occurred in the same foot at different sites. We report a case involving the calcaneus and subsequently the 3rd toe of the same foot and review the reported literature. In established cases of multicentricity, the histopathology has to be properly reviewed and the patient has to be followed up for a longer time with serial whole body assessment to pick up any subsquent lesions. The treatment of the local disease does not differ from a standard GCT.

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“…Multicentric GCTs are extremely rare and represent less than 1% of GCTs [32]. Fewer than 60 cases have been reported in the literature [2,3,7,8,9,10,11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,27,29,30,31,33,35,36]. Therefore, the pathogenesis of multiple benign lesions is still a matter of debate [22].…”

Section: Introductionmentioning

confidence: 98%

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

et al. 2003

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Multicentric giant-cell tumors of the bone (GCTs) are rare. Little is known about the mechanisms by which these tumors spread and how 1% of GCT turn out to be multicentric. We report the case of a 19-year-old woman with metachronous multiple and recurrent GCTs that were unusual in their pattern of progression along the right lower limb over a 23-year period. Histology showed no evidence of malignant transformation. The treatment was repeated curettage and packing with cement. This did not permit a wide surgical margin, but avoided amputation and preserved full limb function. We tested the proliferation index marker Ki-67 in the tumor specimens. Ki-67 expression was limited to the mononuclear cell component of the tumors. The proliferation index was similar in each new tumor and higher in recurrences for each location. In this case, proliferation was initially low in the new tumor location, despite the time difference and independent from the initial clone evolution. Proliferation index increased in recurrent GCTs after marginal margin resection.

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Multicentric Giant Cell Tumor of Bone: A Case Report and Review of the Literature

Cited by 31 publications

References 15 publications

Giant cell tumor of bone: treatment and outcome of 214 cases

Giant cell tumor of bone: treatment and outcome of 214 cases

Multicentric giant cell tumor involving the same foot: A case report and review of literature

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

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