Multicentric Castleman's disease: a case report

Abstract

Castleman's disease is a clinicopathological entity associated with lymphoproliferation. We report a case of a 71 year old gentleman who was initially clinically suspected to have lymphoma (owing to clinical features at presentation), but was later histologically confirmed to have Castleman's disease. This case report underlines the importance of definitive histological diagnosis in patients with lympadenopathic presentation associated with systemic symptoms and the distinctiveness of multicentric Castleman's disease from malignant lymphoma. In this report we also attempt to provide new insight (through the review of medical literature) into the clinical features, pathogenesis, diagnosis and treatment of this rare and relatively benign disorder.

Castleman Disease- An Uncommon And Intriguing Condition Revisited: A Report Of Two Cases

“…Recent studies have demonstrated that HHV-8 is able to produce an IL-6 homologue, the interleukin responsible for hypergammaglobulinaemia and plasmacytosis seen in multicentric Castleman disease (MCD). [12] The controversy remains regarding whether CD variants are separate entities or are two ends of the same spectrum of disease. CD has an increased prevalence in HIV infection.…”

Multicentric Hyaline-Vascular Castleman Disease: A Case Report

“…Two similar cases of hyaline vascular type of multicentric disease in Bangladesh and abroad were managed with steroids resulting in symptomatic relief and disease remission. 12,13 The systemic analysis of patients with Castleman disease by Talat revealed a 78% three-year disease free survival rate for patients with HIV negative multicentric hyaline vascular (and unicentric plasma cell type) variants. 14 The markedly different outcomes and disease associations of the CD variants leaves room for further studies, particularly regarding the modalities of treatment in our country where facilities are often limited.…”

Incidental finding of Castleman's disease in an asymptomatic young adult

“…Castleman’s disease, a very rare lymphoproliferative disorder of unknown cause, was first described over 50 years ago in 1956 by Dr Benjamin Castleman, a pathologist at Massachusetts General Hospital 1 , 2. It was first reported in a group of patients with benign localised hyperplastic lymph nodes 2.…”

“…It was first reported in a group of patients with benign localised hyperplastic lymph nodes 2. Although the aetiology is not completely understood, the pivotal roles of HHV8 and overproduction of interleukin-6 (IL-6) have been emphasised 1.…”