Multicentric Castleman Disease With Ocular Involvement: A Clinicopathologic Case Report

Abstract

To our knowledge, this is the first clinicopathologic report of multicentric Castleman disease involving the eye.

Idiopathic Multicentric Castleman Disease Presenting With Hypertensive Choroidopathy: A Case Report

“…CD rarely leads to direct involvement of the orbit or ocular structures due to a lack of lymphoid tissue in the eye [10]. Several investigators have reported rare intraocular involvement [7][8][9][10][11][12]; however, the pathogenic mechanism of ocular involvement is not fully understood. We report a case of hypertensive choroidopathy in a patient with CD associated with malignant hypertension.…”

“…The choroidopathy seen in this case was thought to be caused by rapid changes in blood pressure due to malignant hypertension. Emerson et al reported choroidal invasion in a patient with CD [ 9 ]. The yellow exudative lesion on the RPE in this case was initially suspected to be caused by direct infiltration of the choroid associated with CD [ 2 , 9 , 15 ].…”

“…Ocular involvement in CD is rare. Although several clinical manifestations, such as serous retinal detachment (SRD), choroidal infiltration [7][8][9], lacrimal gland enlargement, and hypertrophy of orbital soft tissues [10], have been reported, the detailed mechanism is not known. We report a rare case of hypertensive choroidopathy in a patient with CD associated with malignant hypertension.…”

Retinal vein occlusion during flare of multicentric Castleman's disease

“…Ophthalmic complications in MCD are very rare with most published cases describing intraorbital and optic nerve lesions 2,3. Intraocular involvement is rarer with one published adult case of uveitis,4 two cases of bilateral,5,6 one case of unilateral serous retinal detachment and choroidal effusion,7 one case of hypertensive choroidopathy,8 one case of choroidal infiltrates,7 and one case of optic nerve drusen and peripapillary choroidal neovascularization in a patient with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome and associated Castleman’s disease 9. One pediatric case describing venous engorgement and tortuosity, intraretinal hemorrhages, cotton wool spots, and neurosensory detachment of the posterior pole was thought to be due to hyperviscosity syndrome which responded to one session of plasmapheresis 10.…”

Hypertensive choroidopathy in Castleman's disease

“…Orbital involvement such as bilateral enlargement of lacrimal gland and localized orbital soft tissue mass has also been reported [3]. In literature, there was one reported case of bilateral serous retinal detachment and punctate retinal pigment epithelium (RPE) epitheliopathy due to direct tumorous choroidal involvement [4], which was demonstrated histopathologically in another case report of a 69-year-old man with lymphadenopathy and bilateral choroidal infiltrates [5]. We herein report a patient with Castleman's disease who, during the course of the disease, developed hypertensive choroidopathy mimicking direct tumor involvement of choroid.…”