Multicentre trial of high frequency ventilation

Johnson, Alice; Clavert, S; Marlow, Neil; Greenough, A

doi:10.1136/fn.81.2.f159c

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Impact Of Treatment Of An Hsda On Neonatal Morbidity1

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2007

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Cited by 3 publications

(1 citation statement)

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“…Second, the pathogenesis of CLD is multifactorial which makes it highly improbable that any one treatment will prove to be the “magic bullet”. The lack of benefit of inhaled nitric oxide22 and high-frequency ventilation23 in reducing rates of CLD bears this out. Likewise the pathogenesis of NEC is multifactorial.…”

Section: Impact Of Treatment Of An Hsda On Neonatal Morbiditymentioning

confidence: 99%

Towards rational management of the patent ductus arteriosus: the need for disease staging

McNamara

Sehgal²

2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

321

260

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Section: Impact Of Treatment Of An Hsda On Neonatal Morbiditymentioning

confidence: 99%

Towards rational management of the patent ductus arteriosus: the need for disease staging

McNamara

Sehgal²

2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

321

260

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Strategies for prevention of neonatal chronic lung disease

Cole

Fiascone

2000

Seminars in Perinatology

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Neonatal respiratory failure

Rimensberger¹

2002

Current Opinion in Pediatrics

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The classic entity of neonatal distress syndrome, as a lung disease expressing predominant surfactant deficiency, is currently changing to a more complex disease of the developing lung as a result of the number of extremely immature preterm infants. Prenatal factors, such as the fetal inflammatory response syndrome influence short- and long-term outcome in these premature infants presenting with respiratory distress syndrome at birth. Therefore, various previously dismissed treatment strategies, such as surfactant prophylaxis or newer anti-inflammatory approaches have to be reinvestigated in this emerging population. Despite the resurrection of a new picture of bronchopulmonary dysplasia, lung injury induced by mechanical ventilation remains a major issue in neonatal intensive care. With the advance in understanding of mechanical ventilation, it is becoming evident, that improvement in outcome can not be achieved by restoring normal lung physiology in the diseased lung using sophisticated ventilators and ventilation modes. A more disease specific ventilator strategy that will target as early as possible homogenous lung opening while at the same time avoiding overdistention of the lung, has the potential to affect outcome. The possible antiinflammatory properties of surfactant-proteins, nitric oxide and corticosteroids, despite some drawbacks, may show to have a synergistic effect. However, this needs further exploration.

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Multicentre trial of high frequency ventilation

Cited by 3 publications

References 4 publications

Towards rational management of the patent ductus arteriosus: the need for disease staging

Towards rational management of the patent ductus arteriosus: the need for disease staging

Strategies for prevention of neonatal chronic lung disease

Neonatal respiratory failure

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