Multicentre, phase II trial on the safety and efficacy of topical tacrolimus ointment for the treatment of lichen sclerosus

Abstract

Topical tacrolimus ointment 0.1% was safe and effective for the treatment of long-standing active lichen sclerosus.

Treatment of Oral Lichen Sclerosus with 1% Pimecrolimus Cream

“…In another case of oral LSA, the efficacy of topical corticosteroids was insufficient, so grafting treatment was performed to restore gingival health 3 . There have been several case reports of successfully treating anogenital LSA with topical tacrolimus 9 . Furthermore, in a report of vulval LSA, 1% pimecrolimus cream was applied twice daily for 3 months, resulting in complete remission within 6 weeks 10 .…”

“…It reduces antigen presentation and T-cell activation by inhibiting the calcineurin pathway. Moreover, tacrolimus affects other cell types involved in pruritus and inflammation by preventing the cascade of immune and inflammatory signals 9 . Pimecrolimus has a similar mode of action to that of tacrolimus but is more selective and may be better tolerated than topical tacrolimus due to less local irritation.…”

Paediatric vulval lichen sclerosus

“…47 In 2006, a multicentre research group released the results of their phase II trial to assess the safety and efficacy of tacrolimus ointment 0.1% for the treatment of LS. 48 They had 84 patients (49 women, 32 men and three girls) aged between 5 and 85 years with longstanding, active LS, who were treated with topical tacrolimus ointment 0.1% twice daily. Clearance of active LS was reached by 43% of patients at 24 weeks of treatment and partial resolution was reached in a further 34% of patients.…”

Vulvar Dermatoses

“…Takrolimus ve pimekrolimus gibi kalsinörin inhibitörlerinin de etkili olduğu rapor edilmiştir. Ancak bunlarında teorik olarak malignensi potansiyelleri bulunduğu için komplike olmayan olgularda kullanılmaması tavsiye edilmektedir (35,46,47). Şiddetli ve tedaviye cevap vermeyen LS olgularında literatür verileri sınırlı olmakla birlikte sistemik metotreksat, asitretin ve metotreksatla birlikte puls metilprednizolon tedavisi uygulanabilir (48,49).…”