Multicentre Evaluation of Hepika Test Clinical Accuracy in Diagnosing HPV-Induced Cancer and Precancerous Lesions of the Uterine Cervix

Gustinucci, Daniela; Ciccocioppo, Lucia; Coppola, Luigi; Negri, Giovanni; Zannoni, Gian Franco; Passamonti, Basilio; Cesarini, Elena Nardi; Ianzano, Ciro; Andreano, Tiziana; Pireddu, Anjuta; Rossi, Paolo Giorgi

doi:10.3390/diagnostics11040619

Cited by 2 publications

(2 citation statements)

References 50 publications

(19 reference statements)

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“…Adding a p16/Ki67 dual-stain to screening has been reported to increase the detection rate of histological HSIL among hrHPV positive and cytology negative cases [ 35 ]. A positive Hepika test on a cytological sample seems to have a high sensitivity for invasive carcinoma, both squamous and glandular, in comparison to precursor lesions [ 36 ]. Since p16 and Hepika tests are both surrogate markers for hrHPV infection, adding them to the screening protocol in selected cases would probably increase the rate of, or at least provide an earlier detection for endocervical adenocarcinomas.…”

Section: Discussionmentioning

confidence: 99%

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme

et al. 2021

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Most endocervical adenocarcinomas (EAC) are associated with high-risk HPV (hrHPV) infection, with HPV genotypes 16, 18 and 45 accounting for >90% of the cases. Among endocervical glandular lesions, screening with hrHPV test has previously shown to predict the outcome better than cytology, although around one-fifth of the EAC remain negative both in hrHPV testing and cytology. The study consists of two consecutive HPV-primary screening rounds, conducted in 2012–2015 and 2017–2020. Of the 87 women aged 35 to 60 years of age diagnosed with Atypical endocervical cells, NOS or Atypical endocervical cells, favor neoplastic cytology during the first screening round, 63 (72.4%) were hrHPV positive and 24 (27.6%) were hrHPV negative. Among hrHPV positive patients, three EAC, two adenocarcinomas in situ (AIS), one AIS + high-grade intraepithelial lesion (HSIL) and 13 HSIL were found. Of the histologically verified lesions, 68.4% (13/19) were purely of squamous origin. All the EAC and AIS were HPV16 or HPV 18 positive. No high-grade histological lesions were found among the hrHPV negative patients with cytological glandular atypia. A later database search revealed one HPV-negative, gastric-type mucinous EAC that was missed by the HPV primary screening.

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Section: Discussionmentioning

confidence: 99%

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme

et al. 2021

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“…In response to this research question, Gustinucci et al stated that in the diagnosis of gastric cancer, research on the characteristics and accuracy of multislice spiral CT and 3.0 T magnetic resonance imaging provides a more reliable basis for the evaluation of subsequent clinical manifestations [ 5 ]. Bartpho et al compared the value of multislice spiral CT and magnetic resonance imaging (MRI) in the diagnosis of gastric cancer N staging [ 6 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

2022

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In order to explore the diagnostic value of spiral CT and magnetic resonance imaging scanning in gastric cancer and precancerous lesions, the author selected 56 gastric cancer patients treated in a medical center (group) as the experimental subjects, and all patients underwent MRI, multislice spiral CT scan, and enhanced CT scan two weeks before surgery; at the same time, the gastric cancer staging results of patients were diagnosed according to surgical pathology. All patients were examined under the condition of knowledge and performed breath-holding exercise before examination. The status, location, and extent of tumor lesions were evaluated. In comparison of T staging of gastric cancer patients with magnetic resonance scanning imaging and postoperative pathological examination results, among them, T staging of 3 patients did not match the results of pathological examination, the accuracy rates of T staging on magnetic resonance scanning imaging were T 1 = 94.7 % , T 2 = 87.6 % , T 3 = 91.2 % , and T 4 = 94.7 % , and the total accuracy was 92.1%. Comparison of helical CT scan imaging and postoperative pathological examination results is as follows. Among them, T staging of 8 patients did not match the results of pathological examination, 3 patients were ulcerative, 5 were protuberance, the accuracy rates of T staging in spiral CT scan imaging were T 1 = 90.8 % , T 2 = 82.2 % , T 3 = 76.9 % , and T 4 = 87.6 % , and the total accuracy was 84.5%. The total accuracy rate of imaging N staging was 77.5%, and the total accuracy rate of spiral CT scanning imaging N staging was 80.8%. The accuracy rates of M0 and M1 staging in magnetic resonance imaging were 100.0% and 96.5%, respectively, and the accuracy rates of M0 and M1 staging in spiral CT scan imaging were 96.5% and 96.5%, respectively. The accuracy rate of magnetic resonance imaging for the diagnosis of gastric cancer N staging was 77.4%, and the reason for the low accuracy rate was mainly because the enhancement effect was not obvious due to insufficient enhancement. The accuracy rate of spiral CT in diagnosing N staging of gastric cancer was 80.9%, which was mainly due to the small diameter of the middle celiac artery lymph nodes. Magnetic resonance and spiral CT scans have high value in the early diagnosis and staging of gastric cancer.

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Multicentre Evaluation of Hepika Test Clinical Accuracy in Diagnosing HPV-Induced Cancer and Precancerous Lesions of the Uterine Cervix

Cited by 2 publications

References 50 publications

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

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