Multicentre clinicopathological study of adenoid cystic carcinoma: A report of 296 cases

Huang, Zheng; Pan, Juan; Chen, Jiaorong; Wu, Shidi; Wu, Ting; Ye, Haihua; Zhang, Hongfeng; Nie, Xiu; Huang, Changzheng

doi:10.1002/cam4.3707

Cited by 17 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Moreover, another study of 51 patients with ACC of the nasal cavity and paranasal sinuses reported that CK8/18, CK5/6, CD117, SMA, and S100 were expressed in 100%, 100%, 94.1%, 88.3%, and 66.3% of lesions, respectively. 12 In the present case, the initial immunohistochemical findings were CK5/6 (few þ) and p63 (few þ), leading to a diagnosis of nonkeratinizing NPC. However, after 7 months, the second histopathological analysis revealed negativity for CK5/6 and p63, which excluded a squamous cell origin, and positivity for MOC31 and Ber-EP4, suggesting a glandular cell origin, which resulted in a final diagnosis of NAC.…”

Section: Discussionmentioning

confidence: 57%

Epstein–Barr virus-associated poorly differentiated nasopharyngeal adenocarcinoma: a case report and literature review

Zhang

Huang

et al. 2023

J Int Med Res

View full text Add to dashboard Cite

Primary Epstein–Barr virus (EBV)-associated poorly differentiated nasopharyngeal adenocarcinoma (NAC) is an extremely rare tumor. In this study, we report a case of EBV-associated poorly differentiated NAC in a 35-year-old man who presented with a clogging sensation in the right ear for 1 month. The first biopsy of the nasopharynx was suggestive of nonkeratinizing carcinoma with weak positivity for CK5/6 and p63. Based on magnetic resonance imaging of the nasopharynx and neck, chest computed tomography, abdominal ultrasound, and whole-body bone scan, the patient was diagnosed with T3N2M0 disease. After the patient received neoadjuvant chemotherapy, concurrent chemoradiotherapy, and adjuvant chemotherapy, partial remission was observed. However, reassessment after 7 months of treatment revealed tumor enlargement. Transnasal endoscopic resection was performed to remove the nasopharyngeal tumor. The postoperative immunostaining results were as follows: CK5/6 (−), p63 (−), MOC31 (+), and Ber-EP4 (+). Meanwhile, EBV-encoded RNA in situ hybridization was positive. A final diagnosis of EBV-associated poorly differentiated NAC was made. Then, the patient received chemotherapy and irradiation but died several months later because of disease progression. Our patient presented with highly malignant EBV-associated poorly differentiated NAC insensitive to chemoradiotherapy with a short survival time of 27 months.

show abstract

Section: Discussionmentioning

confidence: 57%

Epstein–Barr virus-associated poorly differentiated nasopharyngeal adenocarcinoma: a case report and literature review

Zhang

Huang

et al. 2023

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…All these subtypes can be identified based on the dominant shape and arrangement of the epithelial secreting cells, the myoepithelial cells, and the extracellular matrix. There is no proper protocol to distinguish between these subtypes, but a recent study has suggested that the histologic subtype can be considered to be solid when the solid pattern accounts for more than 30% of the tumor [ 71 ]. A retrospective study of 87 SACC cases indicated that the cribriform subtype was the most encountered histologic pattern of SACC and that the solid was the least common [ 72 ].…”

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

View full text Add to dashboard Cite

Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2. Lesions of SACC are often insidious and slow-growing, and symptoms such as pain and altered sensation are frequently associated with advanced stages of the disease. Salivary adenoid cystic carcinoma is characterized by perineural invasion (PNI), a distinctive feature that potentially plays a significant role in the tumor’s relapse and recurrence, which is approximately 50%. The disease is not prevalent, and its etiopathogenesis is poorly understood, although several genetic patterns and biomarkers have been linked to its initiation and/or progression. The discovery of these mutations and biomarkers has encouraged several clinical studies to use therapeutic agents to target the specific receptors on the cancer cells to potentially prevent further proliferation of the tumor cells and metastasis of the disease. Diagnosis of SACC is often challenging and frequently requires a combination of clinical examination, imaging, and histopathology. Management of SACC is primarily surgical excision, while radiotherapy has shown to be effective in improving local control in cases with microscopic residual disease. However, treatment of recurrent or metastatic tumors by radiotherapy with or without chemotherapy has so far shown limited success. The aim of this thesis is to provide an update of literature on SACC with a particular focus on the latest management approaches and future trends.

show abstract

“…2 Previous studies with a relatively large number of patients have mainly focused on the pathology, immunohistochemical characteristics, treatment, and prognosis of ACC. [12][13][14] The imaging characteristics of salivary gland ACC have not been well described, and most imaging studies have been small series or case reports. 9,15,16 To the best of our knowledge, this is the first study to describe the clinical and US characteristics of ACC in the major salivary glands.…”

Section: Discussionmentioning

confidence: 99%

Polar Vessel

Zhang

et al. 2022

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objectives To investigate the characteristic ultrasonographic findings of adenoid cystic carcinoma (ACC) in major salivary glands and identify the value of polar vessel in color Doppler flow imaging (CDFI) for the diagnosis of ACC. Methods From January 2017 to December 2021, 76 patients with parotid and submandibular gland tumors, including 14 patients with ACC, as confirmed by surgery and histopathology, were enrolled. Their clinicopathologic information and ultrasound (US) features were recorded and analyzed. The performance of polar vessel in CDFI for differentiating ACC from non‐ACC (benign tumors and mucoepidermoid carcinoma [MEC]) was analyzed. Results ACC in the major salivary gland was more likely to be associated with pain symptoms (P = .027) and unclear borders and rough edges in grayscale US (P = .002, .015, respectively) than benign tumors. Compared to MEC, ACC tended to feature a homogeneous internal echo (P = .008). ACC of the major salivary gland had a significantly higher incidence of polar vessel sign than that of non‐ACC (benign tumors and MEC) (P < .0001, .0001, respectively). The polar vessel sign showed good performance in distinguishing between ACC and non‐ACC, with an area under the receiver operating characteristic curve of 0.857, a sensitivity of 71.4%, a specificity of 100%, and an accuracy of 94.7%. Positive predictive value and negative predictive value were calculated at 100% and 93.9%, respectively. Conclusions The US sign of polar vessel has high diagnostic efficiency, and it may have important potential for use as a new complementary sign for the diagnosis of ACC in major salivary glands.

show abstract

Multicentre clinicopathological study of adenoid cystic carcinoma: A report of 296 cases

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 17 publications

References 25 publications

Epstein–Barr virus-associated poorly differentiated nasopharyngeal adenocarcinoma: a case report and literature review

Epstein–Barr virus-associated poorly differentiated nasopharyngeal adenocarcinoma: a case report and literature review

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Polar Vessel

Contact Info

Product

Resources

About