Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron

Abstract

Purpose:To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2* technique for global and segmental measurement of iron overload in thalassemia patients. Materials and Methods:Multiecho T2* sequences were installed on six MRI scanners. Five healthy subjects (n ϭ 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n ϭ 25) within 1 month. T2* images were analyzed using previously validated software.Results: T2* values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2* values the correlation coefficient was 0.97, coefficients of variation (CoV s ) ranged from 0.04 -0.12, and intraclass coefficients (ICC s ) ranged from 0.94 -0.99. The mean CoV and ICC for segmental T2* distribution were 0.198 and 88, respectively. Conclusion:The multislice multiecho T2* technique is transferable among scanners with good reproducibility.

Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2* magnetic resonance imaging study

“…5 All centers are linked by a web-based network, configured to collect and share the patients' history, clinical and diagnostic data. 6 At all six sites, cardiac MRI examinations were performed using 1.5 T scanners.…”

“…11,12 The intraobserver, inter-observer and inter-study variabilities of the proposed methodology have been previously assessed. 5,7 The transferability of multislice multiecho T2* within the MIOT network has been previously validated. 5 Steady-state free procession cine images were acquired to assess ventricular function parameters (left ventricular volumes, mass and ejection fraction) quantitatively in a standard way.…”

“…5,7 The transferability of multislice multiecho T2* within the MIOT network has been previously validated. 5 Steady-state free procession cine images were acquired to assess ventricular function parameters (left ventricular volumes, mass and ejection fraction) quantitatively in a standard way. 13 In brief, 9 to 14 breath-hold short-axis slices (depending on left ventricular size) from the atrioventricular ring to apex were acquired with an 8-mm slice thickness and a 0-mm gap.…”

Single region of interest versus multislice T2* MRI approach for the quantification of hepatic iron overload

“…Inter-site reproducibility within the network was previously assessed (18). MRI was performed using a 1.5 Tesla (T) MRI scanner (GE Signa/Excite HD, Milwaukee, WI).…”

Myocardial fibrosis by delayed enhancement cardiovascular magnetic resonance and HCV infection in thalassemia major patients

“…We analyzed 434 Thalassemia Major (TM) patients (233 males, mean age 31 ± 9 years) consecutively enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) study [1]. CMR was performed using a 1.5 T MR scanner (GE Signa/Excite).…”