Multicenter surveillance study for nosocomial infections in major hospitals in Korea

Kim, June Myung; Park, Eun Suk; Jeong, Jae Sim; Kim, Kyung Mi; Kim, Jeong Mi; Oh, Hyang Soon; Yoon, Sung Won; Chang, Hyun Sook; Chang, Kyung Hee; Lee, Sang Il; Lee, Moo Song; Song, Jae Hoon; Kang, Moon Won; Park, Seung Chul; Choe, Kang Won; Pai, Chik Hyun

doi:10.1067/mic.2000.107592

Cited by 64 publications

(24 citation statements)

References 15 publications

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“…Using active surveillance method not only based on the patient but also on laboratory and monitoring the patients 5 days after discharge of the unit might have been the reason of the higher NI rate. The distribution of infection sites were reported different in some of these studies from the other countries and the same in some [11][12][13]. NIs acquired frequently in ICU is lower respiratory tract, urinary tract, bloodstream, surgical wound and catheter associated infections [13].…”

Section: Discussionmentioning

confidence: 99%

Nosocomial infections and risk factors in intensive care unit of a university hospital in Turkey

et al. 2010

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AbstractThe aim of this study was to determine the types nosocomial infections (NIs) and the risk factors for NIs in the central intensive care unit (ICU) of Trakya University Hospital. The patients admitted to the ICU were observed prospectively by the unit-directed active surveillance method based on patient and the laboratory over a 9-month-period. The samples of urine, blood, sputum or tracheal aspirate were taken from the patients on the first and the third days of their hospitalization in ICU; the patients were cultured routinely. Other samples were taken and cultured if there was suspicion of an infection. Infections were considered as ICU-associated if they developed after 48 hours of hospitalization in the unit and 5 days after discharge from the unit if the patients had been sent to a different ward in the hospital. The rate of NIs in 135 patients assigned was found to be 68%. The most common infection sites were lower respiratory tract, urinary tract, bloodstream, catheter site and surgical wound. Hospitalization in ICU for more than 6 days and colonization was found to be the main risk factor for NIs. Prolonged mechanical ventilation and tracheostomy, as well as frequently changed nasogastric catheterization, were found to be risk factors for lower respiratory tract infections. For bloodstream infections, both prolonged insertion of and frequent change of arterial catheters, and for urinary tract infections, female gender, period and repeating of urinary catheterization were risk factors. A high prevalence rate of nosocomial infections was found in this study. Invasive device use and duration of use continue to greatly influence the development of nosocomial infection in ICU. Important factors to prevent nosocomial infections are to avoid long hospitalization and unnecessary device application. Control and prevention strategies based on continuing education of healthcare workers will decrease the nosocomial infections in the intensive care unit.

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Section: Discussionmentioning

confidence: 99%

Nosocomial infections and risk factors in intensive care unit of a university hospital in Turkey

et al. 2010

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“…20 The difference seems to be associated with the prevalence of MRSA in Korea. 15 Ninety-eight of the 104 isolates had at least one erm gene. When a single resistance determinant was present, erm(A) was the most common.…”

Section: Discussionmentioning

confidence: 99%

A High Frequency of Macrolide-Lincosamide-Streptogramin Resistance Determinants in Staphylococcus aureus Isolated in South Korea

Kim

Lee

Jang

et al. 2004

Microbial Drug Resistance

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Genes conferring resistance to one of the macrolide-lincosamide-streptogramin (MLS) antibiotics may confer cross-resistance to others, because they have similar effects on bacterial protein synthesis. In Korea, over 70% of Staphylococcus aureus isolates are methicillin-resistant and erythromycin-resistant methicillin-resistant S. aureus (MRSA) is also prevalent. We investigated the frequency of MLS resistance in erythromycin-resistant S. aureus isolates. A total of 682 isolates of S. aureus were collected in a nationwide antibiotic resistance survey. Susceptibility to erythromycin, clindamycin, and quinupristin/dalfopristin was tested by disk diffusion. In all, 37% of the methicillin-susceptible S. aureus (MSSA) and 97% of the MRSA isolates were resistant to at least one of the MLS antibiotics, whereas all were susceptible to quinupristin/dalfopristin. Out of 518 strains that were resistant to erythromycin, 60 clindamycin-susceptible (30 MSSA, 30 MRSA) and 44 clindamycin-resistant isolates (14 MSSA, 30 MRSA) were selected at random from these strains. Thirteen genes related to MLS resistance were detected in these isolates by PCR. Of the 104 MSSA and MRSA strains tested, 98 harbored one or more erm gene. The most common was erm(A), with erm(C) next. But, msr(A), lnu(A), and mef(A) were rare and no resistance to streptogramin A was encountered.

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“…mecA유전자는 SCCmec이라는 이동성 유전 자 단위 안에 존재해서 수평적 전파가 이루어진다 [11]. [6,15,16]. The CRE line and data of 1996(*) except MRSA were speculated from general resistant rates of clinical isolates at that time.…”

Section: Mrsa는 1961년 영국에서 첫 보고 되었는데 황색포도알unclassified

Multidrug-resistant Organisms and Healthcare-associated Infections

Kim

2011

Hanyang Med Rev

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Multicenter surveillance study for nosocomial infections in major hospitals in Korea

Cited by 64 publications

References 15 publications

Nosocomial infections and risk factors in intensive care unit of a university hospital in Turkey

Nosocomial infections and risk factors in intensive care unit of a university hospital in Turkey

A High Frequency of Macrolide-Lincosamide-Streptogramin Resistance Determinants in Staphylococcus aureus Isolated in South Korea

Multidrug-resistant Organisms and Healthcare-associated Infections

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