Multicenter Study on Observation of Acute‐phase Responses After Infusion of <scp>Z</scp>oledronic Acid 5 mg in <scp>C</scp>hinese Women with Postmenopausal Osteoporosis

Ding, Yue; Yin, Fei; Zhang, Chunlin; Zhang, Yan; Li, Shi-Xun; Liu, Xun; Zhang, Chao; Xue, Qingyun; Lin, Hua; Pei, Fuxing

doi:10.1111/os.12338

Cited by 33 publications

(30 citation statements)

References 22 publications

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“…Guidelines suggest pretreatment with an NSAID prior to intravenous ZA therapy. 44 Thus, denosumab may provides greater tolerability in outpatients because of the lower risk for acute-phase reaction. In the present study, the increased risk for hypocalcemia in patients administered denosumab may be associated with its strong antiresorptive effect 52 .…”

Section: Discussionmentioning

confidence: 99%

Denosumab Versus Zoledronic Acid in the Prevention of Skeletal-related Events in Vulnerable Cancer Patients: A Meta-analysis of Randomized, Controlled Trials

Chen

Yang

et al. 2020

Clinical Therapeutics

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Section: Discussionmentioning

confidence: 99%

Denosumab Versus Zoledronic Acid in the Prevention of Skeletal-related Events in Vulnerable Cancer Patients: A Meta-analysis of Randomized, Controlled Trials

Chen

Yang

et al. 2020

Clinical Therapeutics

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“…The first intravenous dose of diphosphonates like IBN and ZOL may trigger an acute-phase response (APR) where after their first diphosphonate infusion, patients have had fevers and pains. Commonly, these symptoms were transient in duration and mild to moderate in intensity, and according to NSAID, the incidence and intensity of such an APR could be efficiently impeded (Ding et al 2017). Additionally, the atypical femoral fracture (AFF), an unusual atraumatic or minimal-trauma fracture, has also been reported with increasing frequency in long-term diphosphonate users since the first case reports were published in 2005 (Kim et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "Mapping theme trends and recognizing hot spots in postmenopausal osteoporosis research: a bibliometric analysis (v0.2)"

2019

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This study aimed to draw a series of scientific maps to quantitatively and qualitatively evaluate hot spots and trends in postmenopausal osteoporosis research using bibliometric analysis. Methods: Scientific papers published on postmenopausal osteoporosis were extracted from the Web of Science Core Collection and PubMed database. Extracted information was analyzed quantitatively with bibliometric analysis by CiteSpace, the Online Analysis Platform of Literature Metrology and Bibliographic Item Co-Occurrence Matrix Builder (BICOMB). To explore the hot spots in this field, co-word biclustering analysis was conducted by gCLUTO based on the major MeSH terms/MeSH subheading terms-source literatures matrix. Results: We identified that a total of 5,247 publications related to postmenopausal osteoporosis were published between 2013 and 2017. The overall trend decreased from 1,071 literatures in 2013 to 1,048 literatures in 2017. Osteoporosis International is the leading journal in the field of postmenopausal osteoporosis research, both in terms of impact factor score (3.819) and H-index value (157). The United States has retained a top position and has exerted a pivotal influence in this field. The University of California, San Francisco was identified as a leading institution for research collaboration, and Professors Reginster and Kanis have made great achievements in this area. Eight research hot spots were identified. Conclusions: Our study found that in the past few years, the etiology and drug treatment of postmenopausal osteoporosis have been research hot spots. They provide a basis for the study of the pathogenesis of osteoporosis and guidelines for the drug treatment of osteoporosis.

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“…Indeed, patients display flulike reactions characterized by pyrexia and malaise in the immediate 72 h post BP infusion. 32,90 This appears to be compound dependent. Zoledronic and ibandronic acids have been associated with acute phase reactions in patient populations, such as postmenopausal women and lung cancer patients.…”

Section: Acute Phase Inflammatory Reactionsmentioning

confidence: 96%

Bisphosphonates and atrial fibrillation: revisiting the controversy

Fazmin

Huang

Jeevaratnam

2020

Annals of the New York Academy of Sciences

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Bisphosphonates (BPs) are widely prescribed drugs used to treat osteoporosis, commonly arising in postmenopausal women and in chronic glucocorticoid use. Their mechanism of action is through inhibiting osteoclast‐induced bone remodeling, and they also possess calcium sequestering properties. Common side effects involve the gastrointestinal system and rare but serious side effects, including osteonecrosis of the jaw. However, a link between BPs and atrial fibrillation (AF) has been proposed, with early clinical trials, such as the Fracture Intervention Trial and the HORIZON Pivotal Fracture Trial, reporting that BPs are associated with increased risk of AF. Nevertheless, subsequent studies have reported contrasting results, ranging from no effect of BPs to antiarrhythmic effects of BPs. Preclinical and electrophysiological studies on any proarrhythmic effect of BPs are limited in scope and number, but suggest possible mechanisms that include antiangionesis‐related myocardial remodeling, calcium handling abnormalities, and inflammatory changes. Contrastingly, some studies indicate that BPs are antiarrhythmic by inhibiting fibrotic myocardial remodeling. In order to continue established clinical prescribing of BPs within absolute margins of safety, it will be necessary to systematically rule in/rule out these mechanisms. Thus, we discuss these studies and examine in detail the potential mechanistic links, with the aim of suggesting further avenues for research.

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Multicenter Study on Observation of Acute‐phase Responses After Infusion of Zoledronic Acid 5 mg in Chinese Women with Postmenopausal Osteoporosis

Abstract: Compared with Western populations, Chinese patients had a higher rate of fever and pain after their first zoledronic acid infusion. These symptoms were often mild to moderate in intensity and transient in duration. NSAID could effectively reduce the incidence and severity of such APR.

Cited by 33 publications

References 22 publications

Denosumab Versus Zoledronic Acid in the Prevention of Skeletal-related Events in Vulnerable Cancer Patients: A Meta-analysis of Randomized, Controlled Trials

Denosumab Versus Zoledronic Acid in the Prevention of Skeletal-related Events in Vulnerable Cancer Patients: A Meta-analysis of Randomized, Controlled Trials

Peer Review #3 of "Mapping theme trends and recognizing hot spots in postmenopausal osteoporosis research: a bibliometric analysis (v0.2)"

Bisphosphonates and atrial fibrillation: revisiting the controversy

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