Multicenter study of compliance and drop administration in glaucoma

Kholdebarin, Ramin; Campbell, Robert J.; Jin, Ya-Ping; Buys, Yvonne M.

doi:10.3129/i08-076

Cited by 155 publications

(117 citation statements)

References 25 publications

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“…In other studies, the incidence of missing the eye when attempting to instil an eye drop has ranged from 6.8 to almost 20%, and the incidence of contaminating the bottle tip has ranged from 20 to over 70%. 14,21 Factors associated with poor technique have also been examined with older age, 15 limited school education, 15,16 and poor vision 16 reported to be of importance. Brown et al 13 found that patients attending private practice were more likely to have a good eye drop instillation technique and suggested that this was because the private patients received better instructions on the use of drops; however, the effect of education on instillation technique was not directly examined.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a poor technique is more likely in those with poor manual dexterity, poor vision, limited schooling, and older age. 1,15,16 There is, however, little evidence as to whether education regarding how to self-administer eye drops is associated with a better eye drop instillation technique. Lack of education is likely to be a large problem, as when clinicians prescribe eye drops, proper explanation and demonstration of how the eye drops should be used is often neglected.…”

Section: Introductionmentioning

confidence: 99%

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Eye drop instillation technique in patients with glaucoma

Tatham

Sarodia

Gatrad

et al. 2013

Eye

101

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Aims To evaluate the technique of eye drop instillation in patients with glaucoma and assess factors associated with a good technique. Methods A cross-sectional observational study of 85 participants using selfadministered topical medication for glaucoma or ocular hypertension. Patients were asked to demonstrate how they normally instil eye drops using a 5-ml bottle of sterile artificial tear solution. The procedure was recorded and assessed by two masked graders. Whether the patient had been previously shown how to instil drops, the number of eye medications used, and self-perceived difficulty of using drops were also recorded. Conclusions Education relating to eye drop instillation technique is significantly associated with a patient's ability to instil drops correctly. The assessment of a patient's ability to instil eye drops correctly should be a routine part of the glaucoma examination.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eye drop instillation technique in patients with glaucoma

Tatham

Sarodia

Gatrad

et al. 2013

Eye

101

View full text Add to dashboard Cite

show abstract

“…In both cases, since a key function of aqueous humor is to bathe and nourish the avascular lens, cornea, and TM, reduced aqueous humor circulation through the conventional TM outflow pathway will further exacerbate the condition of the diseased tissue [1,3,7]. In addition, therapeutic compliance remains a very serious issue with published estimates of 27.8%, 50%, or even 75% noncompliance [45][46][47][48]. This is primarily due to side effects and the requirement for daily self-application of eye drops.…”

Section: Discussionmentioning

confidence: 99%

Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle Glaucoma

DW¹,

X²

2016

J Clin Exp Ophthalmol

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Normally, trabecular meshwork (TM) and Schlemm's canal inner wall endothelial cells within the aqueous humor outflow pathway maintain intraocular pressure within a narrow safe range. Elevation in intraocular pressure, because of the loss of homeostatic regulation by these outflow pathway cells, is the primary risk factor for vision loss due to glaucomatous optic neuropathy. A notable feature associated with glaucoma is outflow pathway cell loss. Using controlled cell loss in ex vivo perfused human outflow pathway organ culture, we developed compelling experimental evidence that this level of cell loss compromises intraocular pressure homeostatic function. This function was restored by repopulation of the model with fresh TM cells. We then differentiated induced pluripotent stem cells (iPSCs) and used them to repopulate this cell depletion model. These differentiated cells (TM-like iPSCs) became similar to TM cells in both morphology and expression patterns. When transplanted, they were able to fully restore intraocular pressure homeostatic function. This successful transplantation of TM-like iPSCs establishes the conceptual feasibility of using autologous stem cells to restore intraocular pressure regulatory function in open-angle glaucoma patients, providing a novel alternative treatment option. STEM CELLS 2015;33:751-761

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“…4,6 Hastaların eğitim düzeyleri de tedaviye uyum ve bağlılık üze-rinde etkili bulunmuştur. 7 Glokom hastalarında eğitim seviyesi yükseldikçe, hastaların kullandık-ları ilaçların isimlerini ve uyguladıkları tedavi şe-masını doğru bilme oranları da artmaktadır. 8 Eksik farkındalık ve glokom tedavisine uyum bozukluğu hâlâ birçok ülke için bir sorun gibi görünmekte-dir.…”

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The Importance of Education Level on Treatment Compliance and Awareness in Glaucoma Patients

Şimşek¹,

Bi̇lgi̇n²,

Bilak³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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78Glokom Hastalarının Tedaviye Olan Uyum ve Farkındalığında Eğitim Düzeyinin Önemi Ö ÖZ ZE ET T A Am ma aç ç: Glokom hastalarının tedaviye olan uyum ve farkındalıklarının eğitim düzeyleri ile olan ilişkisini araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: Çalışmaya primer açık açılı glokom tanılı 188 hasta dâhil edildi ve 13 soruluk bir anket uygulandı. Hastaların glokom damlalarını önerilen doz, zaman ve aralıklarla damlatıp damlatmadıkları, ilaçlarını kullanırken yardım alıp almadıkları ve tedaviye uygun süre devam edip etmedikleri sorgulandı ve kaydedildi. Tespit edilen uyumsuzluk nedenlerinin eğitim düzeyleri ile ilişkisi değerlendirildi. Glokom hastalarının eğitim düzeyleri ile hastalıkları hakkındaki bilgi düzeyleri, takip ve tedaviye uyumları arasındaki ilişki araştırıldı. B Bu ul lg gu ul la ar r: : Hastaların eğitim düzeyleri ile cinsiyet, yaş, yaşadıkları yer ve glokom süreleri arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (sırasıyla p= 0,989, p 0,892, p= 0,113, p= 0,999). Hastaların eğitim düzeyleri ile hastalık hakkında bilgi sahibi olma, takip ve körlük gelişme riski hakkındaki farkındalıkları arasında istatistiksel olarak anlamlı bir ilişki saptandı (p<0,001). Glokom hastalarının eğitim düzeyleri ile ilaç isimlerini bilme, ilaçları doğru aralıklarla ve doğru zamanda damlatma konusundaki farkındalıkları arasında istatistiksel olarak anlamlı ilişki saptandı (sırasıyla p<0,001, p<0,001, p= 0,001). Hastaların eğitim düzeyleri ile ilaçlarını kullanırken yardım almaları arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p= 0,432). S So on nu uç ç: : Glokom hastalarının eğitim düzeylerindeki artış, tedaviye olan uyumu ve farkındalığı artırmakta-dır.A An na ah ht ta ar r K Ke el li im me el le er r: : Farkındalık; uyum; glokom, açık açılı

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Multicenter study of compliance and drop administration in glaucoma

Cited by 155 publications

References 25 publications

Eye drop instillation technique in patients with glaucoma

Eye drop instillation technique in patients with glaucoma

Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle Glaucoma

The Importance of Education Level on Treatment Compliance and Awareness in Glaucoma Patients

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