Multicenter, randomized single-port versus multiport laparoscopic surgery (SIMPLE) trial in colon cancer: an interim analysis

Kang, Byung Mo; Kim, Hyung Jin; Kye, Bong-Hyeon; Lee, Sang Chul; Lee, Kil Yeon; Park, Sun Jin; Lee, Suk-Hwan; Lim, Sangwoo; Lee, Yoon Suk; Kim, Ji Hoon; Lee, Jinkwon; Kim, Min Ki; Kim, Jun-Gi

doi:10.1007/s00464-017-5842-0

Cited by 27 publications

(35 citation statements)

References 40 publications

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“…The data for patients receiving conventional perioperative care was extracted from the SIMPLE (multicenter, randomized si ngle-port versus multi-port l aparoscopic surg e ry) trial (ClinicalTrials.gov Identifier: NCT01480128) at Seoul St. Mary’s Hospital and Incheon St. Mary’s Hospital from patients who received surgery between August 2011 and February 2017. The SIMPLE trial was a multicenter, randomized, controlled trial involving seven hospitals in Korea designed to test the hypothesis that the short-term outcome of single-port laparoscopic surgery was non-inferior to that of multi-port laparoscopic surgery in colon cancer 6 . Accordingly, patients were randomized to receive single-port or multi-port surgery, and all received conventional perioperative care.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the effects of an ERAS program and a single-port laparoscopic surgery on postoperative outcomes of colon cancer patients

Kim

Lee

et al. 2019

Sci Rep

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Advancement of the surgical modality and perioperative care are the two main dimensions for the modern improvement of surgical outcome. The purpose of this study was to compare the effectiveness of the two by using the data from the single-port laparoscopic surgery and the early recovery after surgery (ERAS) program. Patients who underwent elective surgery for primary adenocarcinoma of the colon were divided into three groups and compared: ERAS (multi-port laparoscopic surgery with ERAS perioperative care), Conventional-SILS (single-port surgery with conventional perioperative care), or Conventional-Multi (multi-port laparoscopic surgery with conventional perioperative care). Ninety-one, 83, and 96 patients were registered, respectively. There were no differences among the three groups in baseline characteristics except pathological stage and operation site in colon. Although the ERAS group started a soft diet earlier and had earlier discharge, there were no differences in intra- and post-operative morbidity rate, readmission rate, or reoperation rate. The ERAS perioperative care was a significant factor for reducing length of hospital stay in the multivariate analysis, while single-port surgery was not. In modern laparoscopic colon cancer treatment, a systemic approach such as the ERAS program appears to be more effective than a technical approach for significantly improving short-term surgical outcomes.

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Section: Methodsmentioning

confidence: 99%

Comparison of the effects of an ERAS program and a single-port laparoscopic surgery on postoperative outcomes of colon cancer patients

Kim

Lee

et al. 2019

Sci Rep

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“…All surgeries were performed at the three tertiary-referral hospitals where more than 100 colorectal cancer patients are treated annually by seven independent surgeons. These surgeons were qualified through live demonstrations held by the Korean Laparoscopic Colorectal Surgery Study Group, and each submitted a videotape of their laparoscopic rectal surgery, which was subsequently reviewed by a trial steering committee to assess the surgeon's oncological technique [42].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

Lee

Won

et al. 2020

World J Surg Onc

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Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short-and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer. Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed. Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95% confidence interval [CI] 1.04-3.13, p = 0.037, and HR = 1.92, CI 1.02-3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI), and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS. Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.

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“…All surgeries were performed at the three tertiary-referral hospitals where more than 100 colorectal cancer patients are treated annually by seven independent surgeons. These surgeons were quali ed through live demonstrations held by the Korean Laparoscopic Colorectal Surgery Study Group and each submitted a videotape of their laparoscopic rectal surgery, which was subsequently reviewed by a trial steering committee to assess the surgeon's oncological technique [42].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

Lee¹,

Won²,

Oh³

et al. 2020

Preprint

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Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer.Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed.Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95 % confidence interval [CI] 1.04 – 3.13, p = 0.037, and HR = 1.92, CI 1.02 – 3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS.Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.

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Multicenter, randomized single-port versus multiport laparoscopic surgery (SIMPLE) trial in colon cancer: an interim analysis

Abstract: The results of this interim analysis suggested that SPLS is technically safe and appropriate when used for radical resection of colon cancer. (ClinicalTrials.gov Identifier: NCT01480128).

Cited by 27 publications

References 40 publications

Comparison of the effects of an ERAS program and a single-port laparoscopic surgery on postoperative outcomes of colon cancer patients

Comparison of the effects of an ERAS program and a single-port laparoscopic surgery on postoperative outcomes of colon cancer patients

Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

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