Multicenter prospective study of procalcitonin as an indicator of sepsis

Aikawa, Naoki; Fujishima, Seitaro; Endo, S; Sekine, Isao; Kogawa, Kazuhiro; Yamamoto, Yasuhiro; Kushimoto, Shigeki; Yukioka, Hidekazu; Kato, Noboru; Totsuka, Kyoichi; Kikuchi, Ken; Ikeda, Toshiaki; Ikeda, Keisuke; Harada, Kazuaki; Satomura, Shinji

doi:10.1007/s10156-005-0388-9

Cited by 108 publications

(75 citation statements)

References 24 publications

(21 reference statements)

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“…Antibiyotik kullanımı, yavaş üreyen mikroorganizma varlığı ya da kültür ortamına konan kanda bakteri bulunmaması gibi nedenlerle yanlış negatif kan kültü-rü sonucuyla karşılaşılması, bakteriyemili yanık olgularında tedaviyi geciktiren önemli bir sorundur. [1][2][3][4] Bu sebeple, hiper-hipotermi, takipne, taşikardi, lökositoz-lökopeni ile kendini gösteren sistemik enflamatuvar cevap sendromu ile sepsis doğrudan ve aniden kendini gösterebilir.…”

Section: Resultsunclassified

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Bozkurt¹,

Kuvat²,

Kapi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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AMAÇYanık olgularında mortalite ve morbidite erken tanı ile azaltılabilir. Sepsis gibi yanık komplikasyonlarının erken tanısı için çok sayıda belirteç kullanılır. Bu çalışmada, yanık olgularında sayısal/morfolojik granülosit anormallikleri ve komplikasyonlar arasındaki ilişki araştırıldı. Bu sayede, yanık ilintili komplikasyonlar için histopatolojik belirteç/lerin ortaya konulması amaçlandı. GEREÇ VE YÖNTEMKasım 2006 ve Kasım 2009 yılları arasında hastanede yatı-rılan 32 pediatrik yanık olgusu çalışmaya dahil edildi. Toplam 192 tam kan sayımı ve periferal kan yayması sonuçla-rı karşılıklı analiz edildi. Bulgular, beyaz kan hücresi sayı-mı, periferal kan yayması değişiklikleri (immatür granüler hücreler, toksik granülasyon, granül ve Döhle cisimciklerinin görünümü) ve bakteriyemi, sepsis, yara enfeksiyonu, ileri anemi ve greft kaybı gibi komplikasyonlar arasındaki olası korelasyonun saptanmasında kullanıldı. BULGULARBeyaz kan hücresi sayısındaki değişiklikler ve immatür granüler hücrelerin görülmesinin komplikasyonlar için tanısal belirteç olarak kullanımı uygun değildir. Bununla beraber, toksik granülasyon, granül ve Döhle cisimciği görülmesi ile komplikasyonla karşılaşılması arasında istatistiksel olarak anlamlı korelasyon bulunmaktaydı (p: 0,0001<, 0,041, 0,001). SONUÇToksik granülasyon, granül ve Döhle cisimciğinin, yanık ilintili komplikasyonların tahmininde yardımcı olabileceği görünmektedir. Bundan dolayı, periferik kan yaymaları gelecek komplikasyonların tahmininde uygun tetkiklerdir.

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Section: Resultsunclassified

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Bozkurt¹,

Kuvat²,

Kapi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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“…PCT is markedly raised in sepsis upto 1000 times while it is low in viral infections [17,18]. Hence considerable interest has been shown in its usefulness as a biomarker for sepsis, to assess severity and prognosis of patients in sepsis [19,20].…”

Section: Methodsmentioning

confidence: 99%

Role of Semi-quantitative Serum Procalcitonin in Assessing Prognosis of Community Acquired Bacterial Pneumonia Compared to PORT PSI, CURB-65 and CRB-65

Fernandes

Arora

Mesquita

2015

JCDR

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“…Therefore, it is difficult to distinguish bloodstream infections from other diseases with these tests (5, 6). In fact, except for PCR, none of the other tests can on their own confirm the diagnosis of bacteremia (7,8).Interleukins, proatrial natriuretic peptide, copeptin, interferon-ɤ, resistin, and procalcitonin (PCT) have been investigated as potential sepsis biomarkers (7-14), and the most studied among these are PCT levels. Most of these studies have shown that serum PCT levels are low in healthy individuals and elevated in patients with bloodstream infection (11,(13)(14)(15).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Roles of C-Reactive Protein and Procalcitonin in Empirical Treatment Approach to the Bacterial Sepsis Agent

Vurgun¹,

Evliyaoğlu²,

Arabacı³

et al. 2017

Istanbul Med J

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Although the incidence of blood circulation infections such as bacteremia and sepsis can be reduced with appropriate antibiotic treatment when detected at an early stage (1), such infections are one of the most important causes of morbidity and mortality in hospitalized patients (2, 3). Rapid diagnosis of bloodstream infections is often difficult because traditional blood culture procedures are slow and time consuming, and the isolation of the pathogen through the antibiogram takes at least 48 hours after blood culture (4). Alternative laboratory tests such as erythrocyte sedimentation rate, serum C-reactive protein (CRP) levels, white blood cell count or percentage of neutrophils, and polymerase chain reaction (PCR) are used to detect bacteremia but are slow and tedious and lack sensitivity and specificity (1). Therefore, it is difficult to distinguish bloodstream infections from other diseases with these tests (5, 6). In fact, except for PCR, none of the other tests can on their own confirm the diagnosis of bacteremia (7,8).Interleukins, proatrial natriuretic peptide, copeptin, interferon-ɤ, resistin, and procalcitonin (PCT) have been investigated as potential sepsis biomarkers (7-14), and the most studied among these are PCT levels. Most of these studies have shown that serum PCT levels are low in healthy individuals and elevated in patients with bloodstream infection (11,(13)(14)(15). Other investigators have found inconsistent and variable findings when they conducted examinations by comparing the diagnostic and prognostic values of PCT levels with alternative parameters in the case of bacteremia (16,17). Therefore, there is a need for more studies in order for PCT to become a diagnostic or predictive parameter that is routinely recommended.Early identification and recognition of the first minor symptoms of infection at the onset of bloodstream infections can help determine whether patients are infected by gram-positive (gram+) or gram-negative (gram-) pathogens (4). Because serum PCT levels are influenced by lipopolysaccharides and sepsis-related cytokines (18,19), it is expected that serum PCT levels of blood infections caused by gram-pathogens will be higher than blood infections caused by gram+ pathogens.The aim of our study was to determine, in the differential diagnosis, if the predictive value of serum CRP and PCT levels of culture-positive sepsis patients could effectively separate gram+ from gram-bacterial infections at an earlier time point than the standard blood culture results. This would allow us to determine whether or not the correct treatment could be started by facilitat- Roles of C-Reactive Protein and Procalcitonin in Empirical Treatment Approach to the Bacterial Sepsis AgentObjective: The primary aim of our study was to investigate the usefulness of serum C-reactive protein (CRP) and procalcitonin (PCT) levels in the differential diagnosis of causative gram-positive (Gram+) or gram-negative (Gram-) bacteria in patients with sepsis to facilitate decisions concerning the initial choice of...

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Multicenter prospective study of procalcitonin as an indicator of sepsis

Cited by 108 publications

References 24 publications

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Role of Semi-quantitative Serum Procalcitonin in Assessing Prognosis of Community Acquired Bacterial Pneumonia Compared to PORT PSI, CURB-65 and CRB-65

Roles of C-Reactive Protein and Procalcitonin in Empirical Treatment Approach to the Bacterial Sepsis Agent

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