Multicenter Phase Ii Randomized Study Evaluating Dose–response of Antiperistaltic Effect of L‐menthol Sprayed Onto the Gastric Mucosa for Upper Gastrointestinal Endoscopy

Hiki, Naoki; Kaminishi, Michio; Yasuda, Kenjiro; Uedo, Noriya; Kobari, Masumi; Sakai, Terufumi; Hatori, Takashi; Ohno, Kouji; Honjo, Hajime; Nomura, Sachiyo; Yahagi, Naohisa; Tajiri, Hisao; Suzuki, Hiroaki

doi:10.1111/j.1443-1661.2011.01163.x

Cited by 25 publications

(37 citation statements)

References 22 publications

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“…The use of mint EO has demonstrated applications and advantages as antiperistaltic agent during endoscopy [30] and colonoscopy [31]. In the first study gastric peristalsis was quantified using video-recorded endoscopic imaging and the results confirmed the efficacy of the substance in a dose-dependent manner.…”

Section: Postoperative Nausea and Vomitingmentioning

confidence: 96%

Essential Oils for Complementary Treatment of Surgical Patients: State of the Art

Stea

Beraudi

Pasquale

2014

Evidence-Based Complementary and Alternative Medicine

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Aromatherapy is the controlled use of plant essences for therapeutic purposes. Its applications are numerous (i.e., wellbeing, labour, infections, dementia, and anxiety treatment) but often they have not been scientifically validated. The aim of the present study is to review the available literature to determine if there is evidence for effectiveness of aromatherapy in surgical patients to treat anxiety and insomnia, to control pain and nausea, and to dress wound. Efficacy studies of lavender or orange and peppermint essential oils, to treat anxiety and nausea, respectively, have shown positive results. For other aspects, such as pain control, essential oils therapy has shown uncertain results. Finally, there are encouraging data for the treatment of infections, especially for tea tree oil, although current results are still inconclusive. It should also be considered that although they are, allergic reactions and toxicity can occur after oral ingestion. Therefore, while rigorous studies are being carried out, it is important that the therapeutic use of essential oils be performed in compliance with clinical safety standards.

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Section: Postoperative Nausea and Vomitingmentioning

confidence: 96%

Essential Oils for Complementary Treatment of Surgical Patients: State of the Art

Stea

Beraudi

Pasquale

2014

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, it is likely that the addition of menthol may alter the sensitivity of the living plant and human cells to the smoke components, but not the chemical compositions of the combustion gasses. As menthol has been shown to have analgesic, cooling, and muscle relaxing activities by its effect on transient receptor potential cation channel subfamily M member 8 (TRPM8), Kappa receptors stimulation, and inhibition of voltage-gated sodium channels [16,17]. It is tempting to speculate that the menthol-sensitive receptors in both plant cells [18] and animal cells [19] could be putative factors involved in menthol-enhanced toxicity of cigarette smoke.…”

Section: Discussionmentioning

confidence: 99%

Menthol-enhanced cytotoxicity of cigarette smoke demonstrated in two bioassay models

Noriyasu¹,

Konishi²,

Mochizuki³

et al. 2013

Tobacco Induced Diseases

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BackgroundCigarette smoke is harmful to human health at both cellular and genetic levels. Recently, a unique bioassay for smoke cytotoxicity using air pollution-sensitive plant cells (tobacco) has been proposed.MethodsModel plant cells (tobacco Bel-W3 cells) and human cells (alveolar epithelial A549 cells) suspended in fresh culture media were exposed to cigarette smoke sampled after lighting the tip of cigarettes (with vs. without menthol capsules) which were attached to a glass pipe connected to the cell-containing plastic tubes. Control cultures were also assessed.ResultsAfter exposing tobacco plant cells to cigarette smoke, cell death occurred in a dose-dependent manner. Cell death was significantly enhanced by mentholated smoke, while menthol alone was shown to be inert suggesting that menthol synergistically contributes to the enhancement of cell death, initiated by smoke-associated compounds. The enhanced toxicity of mentholated smoke was confirmed in human alveolar epithelial A549 cells.ConclusionsCigarette smoke cytotoxicity leading to cell death assessed in plant and human model cells was enhanced by menthol. Further research into these findings is encouraged.

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“…It enhances smooth muscle relaxation, reduces lower esophageal sphincter tone, and reduces the skin barrier by vasodilation [5, 6]. Adverse reactions to enteric-coated peppermint oil capsules are rare but can include hypersensitivity reaction, contact dermatitis, abdominal pain, acid reflux disease, perianal burning, decrease gastric emptying, bradycardia, and muscle tremor [1, 7, 8].…”

Section: Discussionmentioning

confidence: 99%

Menthol Toxicity: An Unusual Cause of Coma

Baibars

Eng

Shaheen

et al. 2012

Case Reports in Medicine

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The US Food and Drug Administration (FDA) consider menthol an effective substance, which help in common cold symptoms and labeled to have low toxicity profile. Direct exposure to high menthol amount has been reported in animal; but no studies have been done to show the effect of menthol on long-term use in humans. Up to our knowledge we are reporting a rare case of chronic exposure to significant amount of menthol associated with cutaneous, gastrointestinal and neurological manifestations.

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Multicenter Phase Ii Randomized Study Evaluating Dose–response of Antiperistaltic Effect of L‐menthol Sprayed Onto the Gastric Mucosa for Upper Gastrointestinal Endoscopy

Abstract: L-menthol suppresses peristalsis in a dose-dependent manner, and the dose-response reaches a plateau at 0.8% L-menthol. Further Phase III studies are needed to establish the superiority of 0.8% L-menthol over placebo.

Cited by 25 publications

References 22 publications

Essential Oils for Complementary Treatment of Surgical Patients: State of the Art

Essential Oils for Complementary Treatment of Surgical Patients: State of the Art

Menthol-enhanced cytotoxicity of cigarette smoke demonstrated in two bioassay models

Menthol Toxicity: An Unusual Cause of Coma

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