Multicenter comparison of serologic assays and estimation of <i>human herpesvirus 8</i> seroprevalence among US blood donors

Pellett, Philip E.; Wright, Deborah; Engels, Eric A.; Ablashi, Dharam V.; Dollard, Sheila C.; Forghani, Bagher; Glynn, Simone A.; Goedert, James J.; Jenkins, Frank J.; Lee, T. H.; Neipel, Frank; Todd, Deborah; Whitby, Denise; Nemo, George J.; Busch, Michael P.

doi:10.1046/j.1537-2995.2003.00490.x

Cited by 148 publications

(157 citation statements)

References 45 publications

(52 reference statements)

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“…HHV-8 antibody serostatus was assessed by an in-house monoclonal antibody -enhanced immunofluorescent assay against multiple lytic HHV-8 antigens in the laboratory of Dr. Frank J. Jenkins (34). In a comparative study of HHV-8 serologic tests, this assay had a sensitivity of 100% among patients with Kaposi's sarcoma and an estimated sensitivity of 53.4% and specificity of 96.6% among blood donors (35). Once detected, anti -HHV-8 antibodies have been observed to persist for at least 17 years and to increase in titer and range of epitope recognition over time (36), consistent with episodic viral reactivation of this life-long infection.…”

Section: Methodsmentioning

confidence: 99%

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Sutcliffe

Giovannucci

Gaydos

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Traditionally, case-control studies of sexually transmitted infections and prostate cancer have focused on gonorrhea and syphilis, with overall positive associations. More recently, researchers have begun to expand their focus to include additional sexually transmitted infections, such as Chlamydia trachomatis, human papillomavirus (HPV), and human herpesvirus type 8 (HHV-8) infections. Continuing this investigation, we examined each of these infections in relation to incident prostate cancer in a nested case-control study within the Health Professionals Follow-up Study. Prostate cancer cases were men diagnosed with prostate cancer between the date of blood draw (1993)(1994)(1995) and 2000 (n = 691). Controls were men free of cancer and alive at the time of case diagnosis who had had at least one prostatespecific antigen test between the date of blood draw and case diagnosis. One control was individually matched to each case by age; year, time of day, and season of blood draw; and prostate-specific antigen screening history before blood draw (n = 691). C. trachomatis and HPV-16, HPV-18, and HPV-33 antibody serostatus were assessed by enzyme-based immunoassays and HHV-8 antibody serostatus was assessed by an immunofluorescence assay. No associations were observed between C. trachomatis [odds ratio (OR), 1.13; 95% confidence interval (95% CI), 0.65-1.96], HPV-16 (OR, 0.83; 95% CI, 0.57-1.23), HPV-18 (OR, 1.04; 95% CI, 0.66-1.64), and HPV-33 (OR, 1.14; 95% CI, 0.76-1.72) antibody seropositivity and prostate cancer. A significant inverse association was observed between HHV-8 antibody seropositivity and prostate cancer (OR, 0.70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1573 -80)

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Section: Methodsmentioning

confidence: 99%

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Sutcliffe

Giovannucci

Gaydos

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The detection of KSHV infection relies on the presence of antibodies against either lytic and/or latent antigens and varies among the different tests that were used in different seroprevalence studies. In general, the frequency of infection appears to be low in North America, certain Asian countries, and in Northern European nations such as the United Kingdom and Germany, with most studies reporting a seroprevalence rate in normal blood donors of less than 5% [2,[38][39][40]. In these countries the seroprevalence of KSHV in different risk groups mirrors the incidence of AIDS KS, with a seroprevalence rate of between 25-50% among homosexual men.…”

Section: Human Herpesvirus and Ksmentioning

confidence: 99%

AIDS and associated malignancies

Wood

Harrington

2005

Cell Res

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AIDS associated malignancies (ARL) is a major complication associated with AIDS patients upon immunosuppression. Chronically immunocompromised patients have a markedly increased risk of developing lymphoproliferative disease. In the era of potent antiretrovirals therapy (ARV), the malignant complications due to HIV-1 infection have decreased in developed nations where ARV is administered, but still poses a major problem in developing countries where HIV-1 incidence is high and ARV is still not yet widely available. Even in ARV treated individuals there is a concern that the prolonged survival of many HIV-1 carriers is likely to eventually result in an increased number of malignancies diagnosed. Malignancies that were found to have high incidence in HIV-infected individuals are Kaposi's sarcoma (KS), Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). The incidence of NHL has increased nearly 200 fold in HIV-positive patients, and accounts for a greater percentage of AIDS defining illness in the US and Europe since the advent of HAART therapy. These AIDS related lymphomas are distinct from their counterparts seen in HIV-1 seronegative patients. For example nearly half of all cases of ARL are associated with the presence of a gamma herpesvirus, Epstein Barr virus (EBV) or human herpesvirus-8 (HHV-8)/ Kaposi's sarcoma associated herpesvirus (KSHV). The pathogenesis of ARLs is complex. B-cell proliferation driven by chronic antigenemia resulting in the induction of polyclonal and ultimately monoclonal lymphoproliferation may occur in the setting of severe immunosuppression.

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“…Resulting clusters for all the donors will be compared with those for men, women and the six age categories: this will permit to evaluate how the low/high clusters obtained for each sex and age category differ from those obtained for the total population. According to the values of the Kappa Statistic, which varies between 0 and 1, the degree of concordance will be determined as follows: poor (k < 0.2), fair (0.2 ≤ k < 0.4), moderate (0.4 ≤ k < 0.6), good (0.6 ≤ k < 0.8); excellent (k ≥ 0.8), and perfect (k=1) [31,32].…”

Section: Methodsmentioning

confidence: 99%

“…Similarly, unemployment rate is lower for the 18-29 and 60-69 groups but higher for the [30][31][32][33][34][35][36][37][38][39] group. Average income is lower in high donation rate areas for the 30-39, 40-49 and 50-59 analyses while high-education is significantly higher only for the youngest blood donor (the 18-29 age category).…”

Section: Factors Related To the Presence Of High Blood Donation Rate mentioning

confidence: 99%

Blood donation clusters in Québec, Canada (2003–2008): spatial variations according to sex and age

et al. 2013

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Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors

Cited by 148 publications

References 45 publications

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

AIDS and associated malignancies

Blood donation clusters in Québec, Canada (2003–2008): spatial variations according to sex and age

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