Multicenter benchmarking of short and long read wet lab protocols for clinical viral metagenomics
F. Xavier Lopez-Labrador,
Michael Huber,
Igor A. Sidorov
et al.
Abstract:Metagenomics is gradually being implemented for diagnosing infectious diseases. However, in-depth protocol comparisons for viral detection have been limited to individual sets of experimental workflows and laboratories. In this study, we present a benchmark of metagenomics protocols used in clinical diagnostic laboratories initiated by the European Society for Clinical Virology (ESCV) Network on NGS (ENNGS).A mock viral reference panel was designed to mimic low biomass clinical specimens. The panel was used to… Show more
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