“…In this study, we used the multi-block PLS for informed multimodal PLS to find the linkage between FDG PET and volumetric MRI patterns that best distinguished subjects in older and younger subject groups, such that age group membership was an additional (and only dependent) data set. Considering the successful application of multi-block PLS analysis in the field of chemometrics (Lopes et al, 2002; Westerhuis et al, 1996; Westerhuis et al, 1997; Westerhuis and Smilde, 2001), we are interested in extending the multi-block PLS to other brain imaging and non-imaging data sets. For instance, we are interested in characterizing the linkage among three complementary data sets (e.g., FDG PET, fibrillar amyloid images, and volumetric MRI) in either the agnostic or informed mode (i.e., with or without the use of additional dependent information, such as a person’s clinical classification).…”