“…Microneedle (MN) patch has been proposed as a versatile technique and gained a great deal of remarkable achievements in the field of wound healing, as well as disease therapy, biosensing, dermal vaccination, and so on [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. Because of their well-designed microstructures and superior loading capacity compared to those regular drug delivery carriers, MN can effectively realize the load and delivery of the favored active drugs [ [19] , [20] , [21] , [22] , [23] ]. However, the MN widely utilized nowadays is usually fabricated by synthetic polymer materials obtained through complicated chemical synthesis involving environmentally unfriendly organic reagents and harsh experimental treatments, increasing the risk of side effects [ [24] , [25] , [26] , [27] , [28] ].…”