Multiband fMRI as a plausible, time-saving technique for resting-state data acquisition: Study on functional connectivity mapping using graph theoretical measures

Smitha, K A; Arun, K; Rajesh, P.; Joel, Suresh E; Venkatesan, R.; Kesavadas, Chandrasekharan

doi:10.1016/j.mri.2018.06.013

Cited by 11 publications

(4 citation statements)

References 39 publications

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“…Our results also suggest that the new scanning procedures with short TR, such as multi-band acquisitions ( Feinberg and Setsompop, 2013 ; Moeller et al, 2010 ; Smitha et al, 2018 ), should improve functional connectivity estimates by providing more temporal measurements for similar scan duration. As long as the artifacts introduced during these acquisitions are maintained at a negligible level ( Risk et al, 2021 ) and as long as increasing temporal resolution brings useful information for the estimation of BOLD fluctuations within the frequency range of 0.1 to 0.01 Hz commonly selected to study functional connectivity ( Zou et al, 2008 ), an improved temporal resolution should, in theory, better capture the functional networks that are currently well measured and allow for the exploration of sparse networks more difficult to capture.…”

Section: Discussionmentioning

confidence: 60%

Covariance shrinkage can assess and improve functional connectomes

Honnorat

Habes

2022

NeuroImage

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Section: Discussionmentioning

confidence: 60%

Covariance shrinkage can assess and improve functional connectomes

Honnorat

Habes

2022

NeuroImage

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“…For the current study multiband fMRI was used, allowing for increased temporal resolution of resting-state data (Feinberg and Setsompop, 2013;Preibisch et al, 2015) while maintaining reproducibility of results with conventional EPI based fMRI protocols (Smitha et al, 2018). The increase in temporal resolution made possible by multiband fMRI has been suggested to allow for novel insights in brain network dynamics (Preibisch et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4

Quevenco

Bergen

Treyer

et al. 2020

Front. Aging Neurosci.

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Background: Integrity of functional brain networks is closely associated with maintained cognitive performance at old age. Consistently, both carrier status of Apolipoprotein E ε4 allele (APOE4), and age-related aggregation of Alzheimer's disease (AD) pathology result in altered brain network connectivity. The posterior cingulate and precuneus (PCP) is a node of particular interest due to its role in crucial memory processes. Moreover, the PCP is subject to the early aggregation of AD pathology. The current study aimed at characterizing brain network properties associated with unimpaired cognition in old aged adults. To determine the effects of age-related brain change and genetic risk for AD, pathological proteins β-amyloid and tau were measured by Positron-emission tomography (PET), PCP connectivity as a proxy of cognitive network integrity, and genetic risk by APOE4 carrier status. Methods: Fifty-seven cognitively unimpaired old-aged adults (MMSE = 29.20 ± 1.11; 73 ± 8.32 years) were administered 11C Pittsburgh Compound B and 18F Flutemetamol PET for assessing β-amyloid, and 18F AV-1451 PET for tau. Individual functional connectivity seed maps of the PCP were obtained by resting-state multiband BOLD functional MRI at 3-Tesla for increased temporal resolution. Voxelwise correlations between functional connectivity, β-amyloidand tau-PET were explored by Biological Parametric Mapping (BPM). Results: Local β-amyloid was associated with increased connectivity in frontal and parietal regions of the brain. Tau was linked to increased connectivity in more spatially distributed clusters in frontal, parietal, occipital, temporal, and cerebellar regions. A positive interaction was observable for APOE4 carrier status and functional connectivity with brain regions characterized by increased local β-amyloid and tau tracer retention.

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“…This permits extensive undersampling of the k-space, thus allowing fast volume acquisitions, high spatial-resolution and reduced susceptibility artifacts in fMRI. Parallel imaging techniques have been shown to produce resting state networks with higher sensitivity or in less scanning time [124][125][126][127][128] leading to the development of even higher count receive arrays [129,130]. Note that the intrinsic SNR gains of these arrays are largely in the periphery of the brain, but due to their improved parallel imaging performance (e.g.…”

Section: Other Hardwarementioning

confidence: 99%

“…ical number of simultaneously-excited slices is MB2-4 (Multiband factor), up to MB8 for the popular CMRR protocol of the Human Connectome project [38,53], thus allowing an equally reduced TR and potentially improved network detection and shorter scan times [126,128]. When the multiband factor is increased beyond the decoding capabilities of the rf-coil, signal leakage between slices may occur [151].…”

mentioning

confidence: 99%

Neuroimaging at ultra-high spatiotemporal resolutions: line-scanning fMRI

Raimondo

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To be able to investigate the information processing across cortical depth non-invasively, fMRI techniques need to be improved to allow, at the same time, high spatial and temporal resolutions. In this thesis, line-scanning fMRI has been extensively studied as an extreme fMRI approach for ultra-high spatiotemporal resolution. Its one-dimensional nature requires new acquisition strategies as well as customized approaches for data reconstruction and analysis. The reader will be guided through different steps involved in development of line-scanning fMRI technique and its applications, after a short introduction on current fMRI acquisition methods for functional connectomics. Chapter 2 contains a literature review on the current acquisition techniques for resting state fMRI, from the most common approaches for resting state acquisition strategies, to more recent investigations with dedicated hardware and ultra-high fields. This chapter offers an opposite point of view compared to the other chapters, going from an extended, whole brain FOV acquisitions suitable for connectivity analysis to the extremely reduced FOV of the lines, analysed with a strong focus on task-based experiments. In Chapter 3, the first implementation of gradient-echo line-scanning is presented: we analysed the quality of line-scanning data acquisition and optimized the reconstruction strategy. We applied the line-scanning method in the occipital lobe during a visual stimulation task, showing BOLD responses along cortical depth, every 250 mm with a 200 ms repetition time. As proof-of-concept, we compared t-statistical values from line-scanning with 2D gradient-echo echo planar imaging BOLD fMRI data with the same temporal resolution and voxel volume, and showed a good correspondence between the two. In Chapter 4, a comprehensive update to human line-scanning fMRI is introduced. First, we investigated multi-echo line-scanning with different protocols varying the number of echoes and readout bandwidth while keeping the TR constant. We also implemented an adaptation of NOise reduction with DIstribution Corrected principal component analysis (NORDIC) thermal noise removal for line-scanning fMRI data. Finally, we tested image-based navigators for prospective motion correction and examined different ways of performing fMRI analysis on the timecourses, which were influenced by the insertion of the navigators themselves. Together those changes improve the robustness of the line-scanning method. In Chapter 5, an alternative contrast for line-scanning is proposed. Spin-echo is a natural candidate for line-scanning, due to its innate properties of sharp line selection and the microvascular selective functional contrast. However, we could not detect any activation in the visual cortex after a very strong visual task, hence we concluded that further improvements in the spin-echo line-scanning acquisition need to be introduced before it can be applied for neuroscientific purposes. In Chapter 6, an example of line-scanning application is presented: we explored HRF changes in visual cortex across cortical depth in two age groups. We also bridge ageing HRF changes obtained through line-scanning with more conventional fMRI acquisitions at high-field. The thesis concludes with a general discussion in Chapter 7.

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Multiband fMRI as a plausible, time-saving technique for resting-state data acquisition: Study on functional connectivity mapping using graph theoretical measures

Cited by 11 publications

References 39 publications

Covariance shrinkage can assess and improve functional connectomes

Covariance shrinkage can assess and improve functional connectomes

Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4

Neuroimaging at ultra-high spatiotemporal resolutions: line-scanning fMRI

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