Multi-walled carbon nanotubes with poly(methylene blue) composite film for the enhancement and separation of electroanalytical responses of catecholamine and ascorbic acid

Umasankar, Yogeswaran; Chen, Shen‐Ming

doi:10.1016/j.snb.2007.10.040

Cited by 135 publications

(75 citation statements)

References 60 publications

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“…1, top) shows that the integrity of the Teflon-metal seal was not compromised significantly by the cutting procedure used to form the bare disc from the wire. Interesting aspects of the surface structure of PPD formed from the different isomers of phenylenediamine [27][28][29][30] and other electro-deposited polymers [31][32][33] have been revealed in the past by scanning electron microscopy. Crater-like features described previously for PPD formed on metal cylinders from the ortho monomer [27,30] were also evident at higher magnifications for PPD electro-deposited onto the Pt D electrode ( Fig.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Highly selective and stable microdisc biosensors for l-glutamate monitoring

Govindarajan

McNeil

Lowry

et al. 2013

Sensors and Actuators B: Chemical

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a b s t r a c tGlutamate mediates most of the excitatory synaptic transmission in the brain, and its abnormal regulation is considered a key factor underlying the appearance and progression of many neurodegenerative and psychiatric diseases. In this work, a microdisc-based amperometric biosensor for glutamate detection with highly enhanced selectivity and good stability is proposed. The biosensor utilizes the enzyme glutamate oxidase which was dip-coated onto 125 m diameter platinum discs. To improve selectivity, phosphatidylethanolamine was pre-coated prior to enzyme deposition, and electropolymerization of o-phenylenediamine was performed to entrap the enzyme within a polymer matrix. A variety of coating configurations were tested in order to optimize biosensor performance. For stability measurements, biosensors were biased continuously and calibration curves calculated each day for a period of 5-6 days. The optimized biosensors exhibited very high sensitivity (71 ± 1 mA M −1 cm −2 ), low detection limit of ∼2.5 M glutamate, selectivity (over 87% against ascorbic acid), very good temporal stability during continuous use, and a response time of <5 s. These biosensors are therefore good candidates for further development as devices for continuous monitoring during traumatic brain injury or neurosurgery.

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Section: Scanning Electron Microscopymentioning

confidence: 99%

Highly selective and stable microdisc biosensors for l-glutamate monitoring

Govindarajan

McNeil

Lowry

et al. 2013

Sensors and Actuators B: Chemical

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“…The Γ value was calculated from the charge (Q) associated with the electropolymerization process according to (Marinho et al 2012, Yogeswaran andChen 2008):…”

Section: Radical Scavenging Capacitymentioning

confidence: 99%

Poly(methylene blue)-modified electrode for indirect electrochemical sensing of OH radicals and radical scavengers

Braun

Horn

Hoehne

et al. 2017

An. Acad. Bras. Ciênc.

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A new modified electrode for indirect sensing of OH · and radical scavengers was described. The electrochemical polymerization of methylene blue in aqueous solutions and the properties of the resulting films on a glassy carbon electrode were carried out using cyclic voltammetry. A surface coverage of 1.11 × 10 9 mol cm 2 was obtained, revealing a complete surface coverage of the polymeric film on the electrode surface. OH · was able to destroy the poly(methylene blue) film by exposure to a Fenton solution.The loss of the electrochemical signal of the residual polymeric film attached to the electrode surface was related to the extent of its dissolution. The applicability of the sensor was demonstrated by evaluating the OH radical scavenging effect on different concentrations of ascorbic acid. The obtained radical scavenging capacity were 31.4%, 55.7%, 98.9% and 65.7% for the ascorbic acid concentrations of 5, 10, 30 and 50 mM, respectively.

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“…EP and NEP can be detected simultaneously by displaying two well-distinguished anodic peaks with a potential difference of 0.240 V. A CNT paste electrode modified with 2,2′-[1,2-ethanediylbis(nitriloethylidyne)]-bishydroquinone can detect EP in the presence of UA and folic acid (Beitollahi et al, 2008a). MWCNT modified GCE can also be functionalized with poly(methylene blue) (PMB) for detection of EP (Yogeswaran and Chen, 2008). The sensitivity and performance of the sensor are improved by the presence of PMB in the composite film.…”

Section: Neurotransmitters/neurochemicalsmentioning

confidence: 99%

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

Vashist

Zheng

Al‐Rubeaan

et al. 2011

Biotechnology Advances

402

218

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Electrochemical (EC) sensing approaches have exploited the use of carbon nanotubes (CNTs) as electrode materials owing to their unique structures and properties to provide strong electrocatalytic activity with minimal surface fouling. Nanofabrication and device integration technologies have emerged along with significant advances in the synthesis, purification, conjugation and biofunctionalization of CNTs. Such combined efforts have contributed towards the rapid development of CNT-based sensors for a plethora of important analytes with improved detection sensitivity and selectivity. The use of CNTs opens an opportunity for the direct electron transfer between the enzyme and the active electrode area. Of particular interest are also excellent electrocatalytic activities of CNTs on the redox reaction of hydrogen peroxide and nicotinamide adenine dinucleotide, two major by-products of enzymatic reactions. This excellent electrocatalysis holds a promising future for the simple design and implementation of on-site biosensors for oxidases and dehydrogenases with enhanced selectivity. To date, the use of an anti-interference layer or an artificial electron mediator is critically needed to circumvent unwanted endogenous electroactive species. Such interfering species are effectively suppressed by using CNT based electrodes since the oxidation of NADH, thiols, hydrogen peroxide, etc. by CNTs can be performed at low potentials. Nevertheless, the major future challenges for the development of CNT-EC sensors include miniaturization, optimization and simplification of the procedure for fabricating CNT based electrodes with minimal non-specific binding, high sensitivity and rapid response followed by their extensive validation using "real world" samples. A high resistance to electrode fouling and selectivity are the two key pending issues for the application of CNT-based biosensors in clinical chemistry, food quality and control, waste water treatment and bioprocessing.

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Multi-walled carbon nanotubes with poly(methylene blue) composite film for the enhancement and separation of electroanalytical responses of catecholamine and ascorbic acid

Cited by 135 publications

References 60 publications

Highly selective and stable microdisc biosensors for l-glutamate monitoring

Highly selective and stable microdisc biosensors for l-glutamate monitoring

Poly(methylene blue)-modified electrode for indirect electrochemical sensing of OH radicals and radical scavengers

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

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