Multi-walled carbon nanotubes/Nafion composite film modified electrode as a sensor for simultaneous determination of ondansetron and morphine

Nigović, Biljana; Sadiković, Mirela; Sertić, Miranda

doi:10.1016/j.talanta.2014.01.026

Cited by 61 publications

(21 citation statements)

References 25 publications

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“…The GC electrode used for CV experiments was replaced with carbon cloth (CC), which has a higher surface area. MWCNTs were integrated into the CC electrode by soaking the CC in an ethanolic suspension of MWCNTs and 0.02 wt % Nafion, followed by drying (see the Supporting Information for details) . An image of the resulting CC‐MWCNT electrode obtained by scanning electron microscopy (SEM) confirmed the presence of MWCNTs on the surface of carbon fibers (Supporting Information, Figure S3).…”

Section: Methodsmentioning

confidence: 95%

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

2017

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Electrocatalytic methods for organic synthesis could offer sustainable alternatives to traditional redox reactions, but strategies are needed to enhance the performance of molecular catalysts designed for this purpose. Herein, we describe the synthesis of a pyrene-tethered TEMPO derivative (TEMPO = 2,2,6,6-tetra-methylpiperidinyl-N-oxyl) that undergoes facile in situ non-covalent immobilization onto a carbon-cloth electrode. Cyclic voltammetry and controlled potential electrolysis studies demonstrate that the immobilized catalyst exhibits much higher activity relative to, 4-acetamido-TEMPO, an electronically similar homogeneous catalyst. Turnover numbers and frequencies approach 2000 and 4000 h−1, respectively, in preparative electrolysis experiments with a series of alcohol substrates. The synthetic utility of the method is further demonstrated in the oxidation of a sterically hindered hydroxymethylpyrimidine precursor to the blockbuster drug, rosuvastatin.

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Section: Methodsmentioning

confidence: 95%

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

2017

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“…9 Similarly, a Nafion membrane has also been shown to alter the detection of morphine by decreasing the number of peaks observed. 30…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Detection of Morphine and Codeine in the Presence of Ascorbic Acid and Uric Acid and in Human Plasma at Nafion Single-Walled Carbon Nanotube Thin-Film Electrode

et al. 2019

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In clinical settings, the dosing and differential diagnosis of the poisoning of morphine (MO) and codeine (CO) is challenging due to interindividual variations in metabolism. However, direct electrochemical detection of these analytes from biological matrices is inherently challenging due to interference from large concentrations of anions, such as ascorbic acid (AA) and uric acid (UA), as well as fouling of the electrode by proteins. In this work, a disposable Nafion-coated single-walled carbon nanotube network (SWCNT) electrode was developed. We show facile electron transfer and efficient charge separation between the interfering anions and positively charged MO and CO, as well as significantly reduced matrix effect in human plasma. The Nafion coating alters the voltammetric response of MO and CO, enabling simultaneous detection. With this SWCNT/Nafion electrode, two linear ranges of 0.05–1 and 1–10 μM were found for MO and one linear range of 0.1–50 μM for CO. Moreover, the selective and simultaneous detection of MO and CO was achieved in large excess of AA and UA, as well as, for the first time, in unprocessed human plasma. The favorable properties of this electrode enabled measurements in plasma with only mild dilution and without the precipitation of proteins.

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“…[16] An image of the resulting CC-MWCNT electrode obtained by scanning electron microscopy (SEM) confirmed the presence of MWCNTs on the surface of carbon fibers (Supporting Information, Figure S3). MWCNTs were integrated into the CC electrode by soaking the CC in an ethanolic suspension of MWCNTs and 0.02 wt %N afion, followed by drying (see the Supporting Information for details).…”

mentioning

confidence: 80%

“…MWCNTs were integrated into the CC electrode by soaking the CC in an ethanolic suspension of MWCNTs and 0.02 wt %N afion, followed by drying (see the Supporting Information for details). [16] An image of the resulting CC-MWCNT electrode obtained by scanning electron microscopy (SEM) confirmed the presence of MWCNTs on the surface of carbon fibers (Supporting Information, Figure S3).…”

Section: Zuschriftenmentioning

confidence: 99%

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

Das

Stahl

2017

Angewandte Chemie

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Electrocatalytic methods for organic synthesis could offer sustainable alternatives to traditional redox reactions,but strategies are needed to enhance the performance of molecular catalysts designed for this purpose.T he synthesis of ap yrenetethered TEMPO derivative (TEMPO = 2,2,6,6-tetramethylpiperidinyl-N-oxyl) is described, whichu ndergoes facile in situ noncovalent immobilization onto ac arbon cloth electrode. Cyclic voltammetry and controlled potential electrolysis studies demonstrate that the immobilized catalyst exhibits much higher activity relative to 4-acetamido-TEMPO,a ne lectronically similar homogeneous catalyst. In preparative electrolysis experiments with as eries of alcohol substrates and the immobilized catalyst, turnover numbers and frequencies approach 2000 and 4000 h À1 ,respectively.The synthetic utility of the method is further demonstrated in the oxidation of as terically hindered hydroxymethylpyrimidine precursor to the blockbuster drug,r osuvastatin.

show abstract

Multi-walled carbon nanotubes/Nafion composite film modified electrode as a sensor for simultaneous determination of ondansetron and morphine

Cited by 61 publications

References 25 publications

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

Simultaneous Detection of Morphine and Codeine in the Presence of Ascorbic Acid and Uric Acid and in Human Plasma at Nafion Single-Walled Carbon Nanotube Thin-Film Electrode

Noncovalent Immobilization of Molecular Electrocatalysts for Chemical Synthesis: Efficient Electrochemical Alcohol Oxidation with a Pyrene–TEMPO Conjugate

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