Multi-Walled Carbon Nanotubes as Efficient Sorbent for the Solid Bar Microextraction of non-Steroidal Anti-Inflammatory Drugs from Human Urine Samples

Al-Hashimi, Nabil N.; Aleih, Haneen A.; Fasfous, Ismail I.; AlKhatib, Hatim S.

doi:10.2174/1573412913666170317131328

Cited by 6 publications

(2 citation statements)

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“…In this case, signal filtering/enhancing will be essential before running classical PLS calibration. It is rather essential to mention that matrix-cleaning methods may be adopted to eliminate/reduce the influence of interferences before running analysis [22][23][24] . It was necessary to evaluate the effect of dilutions on drugs quantification.…”

Section: Quantification Of Drugs In Real Formulationsmentioning

confidence: 99%

Combination of cumulative area pre- processing and partial least squares for handling intensely overlapping binary and ternary drug systems

Al‐Degs¹,

El‐Sheikh²,

Saaleek³

et al. 2019

actapharm

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The analytical performance of cumulative area pre-processing (CAP), a recently developed signal filtering method, along with multivariate calibration for quantification of spectrally overlying drugs was outlined. The drug combinations containing high level of paracetamol (PAR) in the presence of caffeine (CAF), chlorpheniramine maleate (CHL), pseudoephedrine hydrochloride (PSE), phenylephrine hydrochloride (PHE), and diphenhydramine hydrochloride (DPH). The tested formulations were: PAR-CAF-PHE, PAR-CAF-PHE, and PAR-DRH. Based on netanalyte signal calculations, the formulations exhibited intense overlapping 53-68% for PAR-PSE-CHL, 55-95% for PAR-CAF-PHE, and 44% for PAR-DRH. For each system, PLS latent variables were estimated using cross-validation technique and more factors were needed for highly overlapping systems. PLS-CAP was found applicable for drugs quantification in all systems with excellent performance regardless the size of spectral overlapping and ratios of components in the formulation. For PAR-PSE-CHL (ratio 300:30:2 mg/tablet), the ingredients were quantified by CAP-PLS with satisfactorily recoveries (RSD, n = 3) 89.9% (3.1%), 104.6% (2.7%), and 99.0% (1.5%) for PAR, PSE, and CHL, respectively. Both PLS and CAP-PLS were demonstrated the same performance for binary system of modest overlapping and no component available in low concentration.

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Section: Quantification Of Drugs In Real Formulationsmentioning

confidence: 99%

Combination of cumulative area pre- processing and partial least squares for handling intensely overlapping binary and ternary drug systems

Al‐Degs¹,

El‐Sheikh²,

Saaleek³

et al. 2019

actapharm

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show abstract

“…These materials, nevertheless, are exceedingly complicated, and the solutes are present at minute levels, making analysis extremely challenging. As a result, the basic premise of this methodology procedure has become a significant aspect of the analysis to enrich trace components, increase method sensitivities, and remove interference com-pounds [11]. PE is among the most widely utilized specimen processing techniques for preconcentrating analytes in a wide range of samples because of its characteristics of high enriched uranium component, low organic solvent consumption, high recovery, low cost, rapid phase separation, and the capacity to couple with various identification techniques in either an online or offline mode.…”

Section: Introductionmentioning

confidence: 99%

Bar Adsorbent Microextraction with Carbon-Based Sorbent Layers for the Identification of Pharmaceutic Substances

Thenmozhi

Gowri

Vinayaka³

et al. 2023

Adsorption Science & Technology

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Thirteen carbon materials were tested as sorbent layers in bar adsorbent microextraction (BAμE) to monitor hint amounts of 10 common pharmaceutical compounds (PhCs) in surface and groundwater matrices such as surface and groundwater, saltwater, spring water, and sewage. The persistence of trace amounts of three organophosphate insect repellent and cis and trans permethrin (PERM) in water quality matrices is suggested using bar adsorptive microextraction in conjunction with microliquid dissolution accompanied by significant volume injection-gas chromatography-mass spectroscopic analysis able to operate in the particular ion monitoring acquisition mode. Using BAμE to compare several sorbent coatings (five porous carbon and six polymers), it was discovered that activated carbon (AC2) was the optimum compromise among specificity and effectiveness. 17-estradiol, estrone, sulfamethoxazole, diclofenac, triclosan, gemfibrozil, 17-ethinylestradiol, mefenamic acid, and clofibric acid were chosen as system drugs to represent different treatment groups. Despite their lower porosity, statistics revealed that low-T-activated hydrochars, made from carbohydrates and a eutectic salt mixture at constant temperature (e.g., 180°C) and autogenerated pressures, could compete at the top level commercially carbonaceous materials in this purpose. These L-T-activated hydrochars had the best overall recovery (between 21.8 and 83.5 percent) for the simultaneous analysis of ten targeted PhCs with very different physical and chemical possessions, utilizing higher-efficiency liquid chromatography diode array identification.

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Adsorption and magnetic solid-phase extraction of NSAIDs from pharmaceutical wastewater using magnetic carbon nanotubes: Effect of sorbent dimensions, magnetite loading and competitive adsorption study

El‐Sheikh

Qawariq

Abdelghani

2019

Environmental Technology & Innovation

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Multi-Walled Carbon Nanotubes as Efficient Sorbent for the Solid Bar Microextraction of non-Steroidal Anti-Inflammatory Drugs from Human Urine Samples

Cited by 6 publications

References 0 publications

Combination of cumulative area pre- processing and partial least squares for handling intensely overlapping binary and ternary drug systems

Combination of cumulative area pre- processing and partial least squares for handling intensely overlapping binary and ternary drug systems

Bar Adsorbent Microextraction with Carbon-Based Sorbent Layers for the Identification of Pharmaceutic Substances

Adsorption and magnetic solid-phase extraction of NSAIDs from pharmaceutical wastewater using magnetic carbon nanotubes: Effect of sorbent dimensions, magnetite loading and competitive adsorption study

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