Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results

Xie, Dongxing; Murray, John P; Lartey, Richard; Gaj, Sibaji; Kim, J.; Li, Mei; Eck, Brendan L.; Winalski, Carl S.; Altahawi, Faysal; Jones, Morgan H.; Obuchowski, Nancy A.; Huston, Laura J.; Harkins, Kevin D.; Friel, Harry T.; Damon, Bruce M.; Knopp, Michael V.; Kaeding, Christopher C.; Spindler, Kurt P.; Li, Xiaojuan

doi:10.1016/j.joca.2022.08.006

Cited by 3 publications

(5 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 3D MAPSS CW-T 1ρ sequence has been widely used to evaluate tissue degeneration and monitor compositional changes longitudinally in the MSK system. [31][32][33][34][35][36] Some of the sequence features in 3D MAPSS, such…”

Section: Discussionmentioning

confidence: 99%

“…The 3D MAPSS CW‐T 1ρ sequence has been widely used to evaluate tissue degeneration and monitor compositional changes longitudinally in the MSK system 31–36 . Some of the sequence features in 3D MAPSS, such as magnetization reset, phase modulation, and VFA scheme, 23 have been successfully incorporated in the PM‐UTE‐AdiabT 1ρ sequence.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence

Ma,

Carl,

Tang

et al. 2023

Magnetic Resonance in Med

View full text Add to dashboard Cite

PurposeTo develop a 3D phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence for whole knee joint mapping on a clinical 3 T scanner.MethodsThis new sequence includes six major features: (1) a magnetization reset module, (2) a train of adiabatic full passage pulses for spin locking, (3) a phase modulation scheme (i.e., RF cycling pair), (4) a fat saturation module, (5) a variable flip angle scheme, and (6) a 3D UTE Cones sequence for data acquisition. A simple exponential fitting was used for T1ρ quantification. Phantom studies were performed to investigate PM‐UTE‐AdiabT1ρ's sensitivity to compositional changes and reproducibility as well as its correlation with continuous wave–T1ρ measurement. The PM‐UTE‐AdiabT1ρ technique was then applied to five ex vivo and five in vivo normal knees to measure T1ρ values of femoral cartilage, meniscus, posterior cruciate ligament, anterior cruciate ligament, patellar tendon, and muscle.ResultsThe phantom study demonstrated PM‐UTE‐AdiabT1ρ's high sensitivity to compositional changes, its high reproducibility, and its strong linear correlation with continuous wave–T1ρ measurement. The ex vivo and in vivo knee studies demonstrated average T1ρ values of 105.6 ± 8.4 and 77.9 ± 3.9 ms for the femoral cartilage, 39.2 ± 5.1 and 30.1 ± 2.2 ms for the meniscus, 51.6 ± 5.3 and 29.2 ± 2.4 ms for the posterior cruciate ligament, 79.0 ± 9.3 and 52.0 ± 3.1 ms for the anterior cruciate ligament, 19.8 ± 4.5 and 17.0 ± 1.8 ms for the patellar tendon, and 91.1 ± 8.8 and 57.6 ± 2.8 ms for the muscle, respectively.ConclusionThe 3D PM‐UTE‐AdiabT1ρ sequence allows volumetric T1ρ assessment for both short and long T2 tissues in the knee joint on a clinical 3 T scanner.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence

Ma,

Carl,

Tang

et al. 2023

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…Apart from the patients, six healthy controls (age, 30.7 ± 5.3 years; BMI, 22.9 ± 1.8 kg/m 2 ; three males) without ACLR were scanned and rescanned bi‐laterally (total of 12 legs for the study) using a 3T MR scanner (3T Achieva, Philips). All healthy controls were also recruited under the same PTOA study and informed consent was obtained from all controls 34 . The details of subjects with MRI parameters are given under dataset B in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Bilateral thigh images was performed on 16 patients (age 35.3 ± 5.5 years, body mass index [BMI] 25.5 ± 4.3 kg/m 2 , nine males), who were at least 10 years postoperative after unilateral ACLR on a 3T MR scanner (SkyraFit, Siemens) using anterior/posterior receive arrays. Patients were recruited under an ongoing prospective larger PTOA study, 34 which had approval from the Institutional Review Board and informed consent was obtained from all patients. The MRI protocol contains high‐resolution T 1 ‐weighted turbo spin‐echo (TSE) and 6‐point Dixon MRI scans.…”

Section: Methodsmentioning

confidence: 99%

“…All healthy controls were also recruited under the same PTOA study and informed consent was obtained from all controls. 34 The details of subjects with MRI parameters are given under dataset B in Table 1. As scan and rescan were done in different sessions, we performed registration between them to align these scans (details in Appendix S1: Sec1 and Figure S1).…”

Section: Datasetmentioning

confidence: 99%

See 1 more Smart Citation

Deep learning‐based automatic pipeline for quantitative assessment of thigh muscle morphology and fatty infiltration

Gaj

Eck

Xie

et al. 2023

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose Fast and accurate thigh muscle segmentation from MRI is important for quantitative assessment of thigh muscle morphology and composition. A novel deep learning (DL) based thigh muscle and surrounding tissues segmentation model was developed for fully automatic and reproducible cross‐sectional area (CSA) and fat fraction (FF) quantification and tested in patients at 10 years after anterior cruciate ligament reconstructions. Methods A DL model combining UNet and DenseNet was trained and tested using manually segmented thighs from 16 patients (32 legs). Segmentation accuracy was evaluated using Dice similarity coefficients (DSC) and average symmetric surface distance (ASSD). A UNet model was trained for comparison. These segmentations were used to obtain CSA and FF quantification. Reproducibility of CSA and FF quantification was tested with scan and rescan of six healthy subjects. Results The proposed UNet and DenseNet had high agreement with manual segmentation (DSC >0.97, ASSD < 0.24) and improved performance compared with UNet. For hamstrings of the operated knee, the automated pipeline had largest absolute difference of 6.01% for CSA and 0.47% for FF as compared to manual segmentation. In reproducibility analysis, the average difference (absolute) in CSA quantification between scan and rescan was better for the automatic method as compared with manual segmentation (2.27% vs. 3.34%), whereas the average difference (absolute) in FF quantification were similar. Conclusions The proposed method exhibits excellent accuracy and reproducibility in CSA and FF quantification compared with manual segmentation and can be used in large‐scale patient studies.

show abstract

Chondral Injury Associated With ACL Injury: Assessing Progressive Chondral Degeneration With Morphologic and Quantitative MRI Techniques

Davidson,

Figgie,

Nguyen

et al. 2023

Sports Health: A Multidisciplinary Approach

View full text Add to dashboard Cite

Background: Anterior cruciate ligament (ACL) injuries are associated with a risk of post-traumatic osteoarthritis due to chondral damage. Magnetic resonance imaging (MRI) techniques provide excellent visualization and assessment of cartilage and can detect subtle and early chondral damage. This is often preceding clinical and radiographic post-traumatic osteoarthritis. Hypothesis: Morphologic and quantitative MRI techniques can assess early and progressive degenerative chondral changes after acute ACL injury. Study Design: Prospective longitudinal cohort. Level of Evidence: Level 3. Methods: Sixty-five participants with acute unilateral ACL injuries underwent bilateral knee MRI scans within 1 month of injury. Fifty-seven participants presented at 6 months, while 54 were evaluated at 12 months. MRI morphologic evaluation using a modified Noyes score assessed cartilage signal alteration, chondral damage, and subchondral bone status. Quantitative T1ρ and T2 mapping at standardized anatomic locations in both knees was assessed. Participant-reported outcomes at follow-up time points were recorded. Results: Baseline Noyes scores of MRI detectable cartilage damage were highest in the injured knee lateral tibial plateau (mean 2.5, standard error (SE) 0.20, P < 0.01), followed by lateral femoral condyle (mean 2.1, SE 0.18, P < 0.01), which progressed after 1 year. Longitudinal prolongation at 12 months in the injured knees was significant for T1ρ affecting the medial and lateral femoral condyles ( P < 0.01) and trochlea ( P < 0.01), whereas T2 values were prolonged for medial and lateral femoral condyles ( P < 0.01) and trochlea ( P < 0.01). The contralateral noninjured knees also demonstrated T1ρ and T2 prolongation in the medial and lateral compartment chondral subdivisions. Progressive chondral damage occurred despite improved patient-reported outcomes. Conclusion: After ACL injury, initial and sustained chondral damage predominantly affects the lateral tibiofemoral compartment, but longitudinal chondral degeneration also occurred in other compartments of the injured and contralateral knee. Clinical Relevance: Early identification of chondral degeneration post-ACL injury using morphological and quantitative MRI techniques could enable interventions to be implemented early to prevent or delay PTOA.

show abstract

Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results

Cited by 3 publications

References 55 publications

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence

Deep learning‐based automatic pipeline for quantitative assessment of thigh muscle morphology and fatty infiltration

Chondral Injury Associated With ACL Injury: Assessing Progressive Chondral Degeneration With Morphologic and Quantitative MRI Techniques

Contact Info

Product

Resources

About

Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results

Cited by 3 publications

References 55 publications

Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence

Whole knee joint mapping using a phase modulated UTE adiabatic T1ρ (PM‐UTE‐AdiabT1ρ) sequence

Deep learning‐based automatic pipeline for quantitative assessment of thigh muscle morphology and fatty infiltration

Chondral Injury Associated With ACL Injury: Assessing Progressive Chondral Degeneration With Morphologic and Quantitative MRI Techniques

Contact Info

Product

Resources

About

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence

Whole knee joint mapping using a phase modulated UTE adiabatic T_1ρ (PM‐UTE‐AdiabT_1ρ) sequence