Multi-target mechanism of Solanum xanthocarpum for treatment of psoriasis based on network pharmacology and molecular docking

Sahu, Nilanchala; Madan, Swati; Walia, Ramanpreet; Tyagi, Rama; Fantoukh, Omer I.; Hawwal, Mohammed F.; Akhtar, Ali; Almarabi, Ibrahim; Alam, Perwez; Saxena, Shikha

doi:10.1016/j.jsps.2023.101788

Cited by 4 publications

(3 citation statements)

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“…The efficacy of herbal treatments in psoriasis remains a subject of ongoing research, with some studies suggesting potential benefits in symptom relief and inflammation reduction [16]. The medicinal properties of SX include anti-psoriatic, antiinflammatory, anticancer, immunosuppressive and wound-healing potential [17]. However, due to the size of vesicles in nanometers, their solubility and their improved permeability, extracts have permeation-related concerns that may be minimized by formulating them into a nanoformulation, increasing their bioavailability with pharmacological action, etc.…”

Section: Discussionmentioning

confidence: 99%

Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract of Solanum xanthocarpum for the Topical Treatment of Psoriasis

Sahu,

Alam,

Ali

et al. 2024

Gels

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The goal of this investigation is to improve the topical delivery of medicine by preparing and maximizing the potential of a nanotransferosome gel infused with Solanum xanthocarpum methanolic extract (SXE) to provide localized and regulated distribution. Thin-film hydration was used to create SXE-infused nanotransferosomes (SXE-NTFs), and a Box–Behnken design was used to improve them. Phospholipon 90G (X1), cholesterol (X2) and sodium cholate (X3) were chosen as the independent variables, and their effects on vesicle size (Y1), polydispersity index (PDI) (Y2) and the percentage of entrapment efficiency (EE) (Y3) were observed both individually and in combination. For the SXE-NTFs, the vesicle size was 146.3 nm, the PDI was 0.2594, the EE was 82.24 ± 2.64%, the drug-loading capacity was 8.367 ± 0.07% and the drug release rate was 78.86 ± 5.24%. Comparing the antioxidant activity to conventional ascorbic acid, it was determined to be 83.51 ± 3.27%. Ex vivo permeation tests revealed that the SXE-NTF gel (82.86 ± 2.38%) considerably outperformed the SXE gel (35.28 ± 1.62%) in terms of permeation. In addition, it seemed from the confocal laser scanning microscopy (CLSM) picture of the Wistar rat’s skin that the rhodamine-B-loaded SXE-NTF gel had a higher penetration capability than the control. Dermatokinetic studies showed that the SXE-NTF gel had a better retention capability than the SXE gel. According to the experimental results, the SXE-NTF gel is a promising and successful topical delivery formulation.

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Section: Discussionmentioning

confidence: 99%

Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract of Solanum xanthocarpum for the Topical Treatment of Psoriasis

Sahu,

Alam,

Ali

et al. 2024

Gels

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“…The Venn diagram ( https://bioinfogp.cnb.csic.es/tools/venny/ ) 21 was populated with the identified targets of the five individual drug with the targets related to PSO disease 22 . To further investigate potential objectives, we collected the targets that overlapped between triazole drugs and those associated with PSO.The STRING platform (https://string-db.org/)…”

Section: Prediction Of Mutual Targets and Construction Of Ppi Networkmentioning

confidence: 99%

“…The words of significantly enriched CCs, MFs, and BPs were displayed (P value 0.05, minimum count of 3, and enrichment factor>1.5) 29 . The bioinformatics platform (https://omicstutorials.com/bioinformatics-tools-softwares-programmes/) was used to construct the GO and KEGG enrichment bubble chart 21,30 .…”

Section: Gene Ontology (Go) and Kyoto Encyclopaedia Of Genes And Geno...mentioning

confidence: 99%

Identification of Therapeutic Potential of Triazole Antifungal Drugs in Psoriasis using Network Pharmacological Approach

Satpathy,

Sahu,

Nagpal

et al. 2024

Preprint

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Psoriasis (PSO) is a chronic immune-mediated skin condition characterized by abnormal keratinocyte growth and inflammation. Clinical occurrences have hinted to a potential connection between fungi and psoriasis as several Malassezia species and Candida Albicans species have been linked to distinct psoriasis subtypes. Triazoles Antifungal drugs have been used mainly to treat Fungal diseases. In this study, we intend to find out different target mechanism pathway through which triazoles drugs can act in the pathophysiology of psoriasis by Network pharmacology approach. Utilizing Swiss Target Prediction, GeneCard, Pharmmapper, Venn diagram analysis, String database, and Cytoscape, the study identified 76 mutual targets out of 4492 for psoriasis and 294 for triazole derivatives. The PPI network highlighted core targets such as CASP3, CCL5, SRC, PPARG, STAT1, MMP9, EGFR, IL2, ESR1, and AKT1. KEGG pathway enrichment analysis unveiled relevant pathways, including proteoglycans in cancer and Th17 cell differentiation. The network pharmacology study and molecular docking method shows multi-target pathway mechanism of triazole antifungal drugs.

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Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

Zeng,

Wu,

Chen

et al. 2024

Peptide Science

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Gastric cancer (GC) is the most common type of cancer of the digestive system with high morbidity and mortality. Chemotherapy and targeted therapy are used to treat patients with advanced GC. However, side effects and drug resistance to the two modalities remain the main challenges. The Buzhong Yiqi decoction (BZYQD), a classical traditional Chinese medicine formula, has been reported for the treatment of various types of cancers. However, the underlying pharmacological mechanism has not been fully elucidated. Therefore, this study integrated network pharmacology, molecular docking, cancer public databases, and cell experiments to explore the potential bioactive compounds and BZYQD's mechanism of action against GC. A total of 245 targets of BZYQD, 5291 GC‐related targets, and 186 were identified as their common targets through the database. Network analysis confirmed AKT1, TP53, TNF, and EGFR to be the core targets, while the main compounds observed were quercetin, kaempferol, and β‐Sitosterol. The core signaling pathways included PI3K‐AKT, MAPK, TNF, and IL‐17. Molecular docking revealed good binding activity for the main compounds and core targets. Based on the database's validation of core targets, a large number of core genes were verified to be consistent with this study. Quercetin, kaempferol, and β‐Sitosterol were found to significantly reduce the growth of GC cells in the MTT experiment. The current study revealed that BZYQD may inhibit GC progression by interfering with core targets such as AKT1, TP53, TNF, EGFR, and MAPK3, and by regulating the activity of PI3K‐AKT, MAPK, TNF, and IL‐17 signaling pathways.

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Multi-target mechanism of Solanum xanthocarpum for treatment of psoriasis based on network pharmacology and molecular docking

Cited by 4 publications

References 54 publications

Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract of Solanum xanthocarpum for the Topical Treatment of Psoriasis

Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract of Solanum xanthocarpum for the Topical Treatment of Psoriasis

Identification of Therapeutic Potential of Triazole Antifungal Drugs in Psoriasis using Network Pharmacological Approach

Molecular Mechanisms of Buzhong Yiqi Decoction in the Treatment of Gastric Cancer: A Network Pharmacology, Molecular Docking, and In Vitro Experimental Analysis

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