Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Dual inhibition: a novel promising pharmacological approach for different disease conditions

“…The first dual inhibitors of AChE and BACE-1 were reported by Lorna Piazzi and co-workers. [64] Recently, a series of novel dual inhibitors have been reported to possess in-vitro enzyme-inhibitory potency and cellular activity, and in-vivo functional efficacy. Among them, an inhibitor coded as 28, i.e.…”

Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors

“…The presence of coumarin architecture in naturally occurring phytoconstituents with anticancer 15,16 , anti-HIV 17 , antituberculosis 18 , anti-influenza 19 , antialzheimer 20,21 , anti-inflammatory 22 , antiviral 23 , antimicrobial 13 and xanthine oxidase inhibitory activities [24][25][26] makes it a privileged structure. Among the diverse array of biological activities possessed by coumarins, we are particularly interested towards their xanthine oxidase inhibitory potential which has also been extensively explored [24][25][26] .…”

2,4-Diarylpyrano[3,2-<i>c</i>]chromen-5(4<i>H</i>)-ones as Antiproliferative Agents:

“…[14][15][16][17][18][19] Coumarins form an important class of compounds, which occupy a special role in nature. 20,21) The presence of coumarin architecture in naturally occurring phytoconstituents such as anticancer, 22,23) anti-human immunodeficiency virus (HIV), 24) antituberculosis, 25) anti-influenza, 26) anti-Alzheimer, 27,28) antiinflammatory, 29) antiviral 30) and antimicrobial agents 20) makes it a privileged structure. Though coumarin posseses diverse array of biological activities but their ability to kill cancer cells through varied mechanisms has been explored in detail.…”