Multi-target activity of copper complexes: Antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor

Evaluation of multi-target iridium(iii)-based metallodrugs in combating antimicrobial resistance and infections caused by Staphylococcus aureus

“…[7][8][9] In fact, metal-based antibacterial agents have also received extensive attention and possess huge potential to address drug-resistant bacterial infections. [10][11][12][13][14] It has been reported that iridium(III) complexes bearing polypyridine moieties showed obvious antibacterial activity against Gram-positive bacteria such as S. aureus. [15][16][17][18] Meanwhile, ruthenium-based complexes, which could disrupt the integrity of the bacterial membrane, not only exhibited robust antibacterial efficacy against Gram-positive bacteria but also effectively blocked the generation of bacterial resistance.…”