Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Animal models for epileptic foci localization, seizure detection, and prediction by electrical impedance tomography

“…From elemental creatures to nonmammalian species (Johan Arief et al, 2018) to nonhuman primates, epileptic models have been examined in many experimental animals. Rats (Patra et al, 2018), mice (Bertoglio et al, 2017), cats (Löscher, 2017), rabbits (Bosinski et al, 2021), pigs (Witkowska‐Wrobel et al, 2021), baboons (Croll et al, 2019), and macaques (Chen et al, 2013) are commonly used for epileptic model preparation. Among them, rats and mice are the most widely utilized experimental animals.…”

It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade

“…Recent reports indicate the value of canines, rabbits, and primates for SUDEP research and neurotherapeutics. [59][60][61][62][63] Interestingly, like humans, epileptic baboons exhibit cardiac ECG and autonomic abnormalities, 61,62 and they better reproduce human cardiac electrical function. 57,64 Additionally, the field is closing in on developing precision medicine to treat genetic epilepsies, which requires the identification of rigorous preclinical animal models with reproducible phenotypes relevant to humans.…”

“…As mice do not fully recapitulate human neurocardiac function, 57,58 there is a need for new translational models of SUDEP. Recent reports indicate the value of canines, rabbits, and primates for SUDEP research and neurotherapeutics 59–63 . Interestingly, like humans, epileptic baboons exhibit cardiac ECG and autonomic abnormalities, 61,62 and they better reproduce human cardiac electrical function 57,64 .…”