Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery

Palmese, Luisa L; Fan, Ming; Scott, R.; Tan, Huaping; Kiick, Kristi L.

doi:10.1080/09205063.2020.1855392

Cited by 21 publications

(14 citation statements)

References 84 publications

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“…The liposomes were prepared by a traditional thin-film dehydration-rehydration protocol, followed by sequential extrusion through membrane filters with pore sizes of 200 and 100 nm, respectively . Lipids with a molar ratio of 73:24:3 (DPPC/Cholesterol/DSPE-PEG-Mal) were mixed in 4:1 chloroform and methanol (v/v) and added to a round-bottom flask.…”

Section: Methodsmentioning

confidence: 99%

Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections

et al. 2023

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Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance stemming from frequent dosing diminishes drug efficacy and contributes to recurrent infection. To identify improvements in antibiotic therapies, new antibiotic delivery systems that maximize pharmacological activity and minimize side effects are needed. In this study, we developed elastin-like peptide and collagen-like peptide nanovesicles (ECnVs) tethered to collagencontaining matrices to control vancomycin delivery and provide extended antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA). We observed that ECnVs showed enhanced entrapment efficacy of vancomycin by 3-fold as compared to liposome formulations. Additionally, ECnVs enabled the controlled release of vancomycin at a constant rate with zero-order kinetics, whereas liposomes exhibited first-order release kinetics. Moreover, ECnVs could be retained on both collagen-fibrin (co-gel) matrices and collagen-only matrices, with differential retention on the two biomaterials resulting in different local concentrations of released vancomycin. Overall, the biphasic release profiles of vancomycin from ECnVs/co-gel and ECnVs/ collagen more effectively inhibited the growth of MRSA for 18 and 24 h, respectively, even after repeated bacterial inoculation, as compared to matrices containing free vancomycin, which just delayed the growth of MRSA. Thus, this newly developed antibiotic delivery system exhibited distinct advantages for controlled vancomycin delivery and prolonged antibacterial activity relevant to the treatment of wound infections.

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Section: Methodsmentioning

confidence: 99%

Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections

et al. 2023

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“…Chitosan and PNIPAAm can be also combined to form multiphase wound healing hydrogels where chitosan imparted improved biocompatibility, while PNIPAAm provided a thermally triggered volume change for enhanced control of drug delivery ( Hogan and Mikos, 2020 ). Another approach in developing “smart’ multiresponsive hydrogels is via the incorporation of temperature-sensitive additives, such as liposomes or nanoparticles ( Lu and Ten Hagen, 2020 ; Palmese et al, 2020 ). Recently, Pedersen et al (2020) developed hydrogel biomaterials with triggered liquefaction in response to internal, localized heating, mediated by near-infrared light as external stimulus.…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

“…Growth factor receptor-bound protein-2 liposomes were prepared to inhibit the production of the growth factor receptor-bound protein-2 and, thereby, to reduce the proliferation of tumor cells ( Saraf et al, 2020 ). TSL administration can be done directly in suspension (e.g., intravenous injection) or by loading them into injectable hydrogels to sequential delivery of multiple drugs ( Lu and Ten Hagen, 2020 ; Palmese et al, 2020 ). In a recent work, Palmese et al (2020) synthesized an injectable crosslinked poly(ethylene glycol) hydrogel containing both chemically crosslinked TSLs and matrix metalloproteinase-sensitive peptide crosslinks capable of independently responding to matrix metalloproteinase and applied hyperthermia.…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

“…TSL administration can be done directly in suspension (e.g., intravenous injection) or by loading them into injectable hydrogels to sequential delivery of multiple drugs ( Lu and Ten Hagen, 2020 ; Palmese et al, 2020 ). In a recent work, Palmese et al (2020) synthesized an injectable crosslinked poly(ethylene glycol) hydrogel containing both chemically crosslinked TSLs and matrix metalloproteinase-sensitive peptide crosslinks capable of independently responding to matrix metalloproteinase and applied hyperthermia. Doxorubicin, a widely used anticancer drug, was loaded in the TSLs with a high encapsulation efficiency, and the subsequent release was temperature dependent.…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

“…Experiments characterizing the in situ drug delivery and degradation of these materials indicate that the TSL gel responds to both thermal and enzymatic stimuli in a local environment. The timescales of release associated with these two stimuli are distinct, allowing for the potential loading and independent delivery of multiple compounds ( Palmese et al, 2020 ).…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

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Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

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In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

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Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Liu

et al. 2023

Advanced Therapeutics

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Tissue loss through injury, surgery, and disease motivates the development of new biomaterials to enable tissue repair and regeneration. Emerging at the interface between bioadhesives and regenerative medicine, a new generation of regenerative bioadhesives is created to possess dual functions of seamless tissue adhesion and effective tissue repair. This bioadhesive innovation has wide clinical applications, ranging from wound management to the regeneration of musculoskeletal tissues such as tendons and intervertebral discs. This perspective covers the design principles of regenerative bioadhesives in considering both mechanical and biological elements. Case studies of regenerative bioadhesives for load‐bearing organs such as skin, tendon, and intervertebral discs are presented here. Finally, immediate opportunities and future perspectives are outlined to further advance the field of regenerative bioadhesives.

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Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery

Cited by 21 publications

References 84 publications

Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections

Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

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