Multi-stimuli-responsive biohybrid nanoparticles with cross-linked albumin coronae self-assembled by a polymer-protein biodynamer

Wang, Lin; Liu, Li; Dong, Bingyang; Zhao, Hanying; Zhang, Mingming; Chen, Wenjuan; Hong, Yanhang

doi:10.1016/j.actbio.2017.03.009

Cited by 25 publications

(23 citation statements)

References 57 publications

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“…Wang et al presented a promising multi‐stimuli‐responsive biohybrid PNC having cross‐linked bovine serum albumin corona which was self‐assembled by copolymer‐protein biodynamer ( Figure 13 a ). [ 269 ] The pyridylhydrazone linkers used in this work was cleaved in an acidic milieu which was a mimic of the intracellular environment and subsequently the protein was released. Here, the protein biodynamer self‐assembled into micelle type PNC above its lower critical solution temperature (LCST).…”

Section: Multi‐stimuli‐responsive and Multi‐drug Delivery: The Way Fo...mentioning

confidence: 99%

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Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Mahata

Kim

2022

Advanced Science

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Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to cells but also to subcellular organelles. Variety of natural sources, availability of different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, and biodegradability have presented polymers as one of the most desired materials for nanocarrier design. Recent innovative concepts and advances in PNC-associated nanotechnology are providing unprecedented opportunities to engineer nanocarriers and their functions. The efficiency of therapeutic loading has got considerably increased. Structural design-based varieties of PNCs are widely employed for the delivery of small therapeutic molecules to genes, and proteins. PNCs have gained ever-increasing attention and certainly paves the way to develop advanced nanomedicines. This article presents a comprehensive investigation of structural design-based varieties of PNCs and the influences of their physicochemical properties on drug delivery profiles with perspectives highlighting the inevitability of incorporating both the multi-stimuli-responsive and multi-drug delivery properties in a single carrier to design intelligent PNCs as new and emerging research directions in this rapidly developing area.

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Section: Multi‐stimuli‐responsive and Multi‐drug Delivery: The Way Fo...mentioning

confidence: 99%

Section: Multi‐stimuli‐responsive and Multi‐drug Delivery: The Way Fo...mentioning

confidence: 99%

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Mahata

Kim

2022

Advanced Science

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“…NP-based drug delivery systems are also constructed to be responsive to other overexpressed proteases in tumor cells including cathepsin B, trypsin, and chymotrypsin. 23,29 Stimuli responsiveness may also be specific to parts of the body by targeting the enzymes from which they derive function. The human gut microbiota contains a wide array of microorganisms whose enzymatic capabilities are crucial to digestion, homeostasis, and the immune system.…”

Section: ■ Moieties For Stimuli Responsivenessmentioning

confidence: 99%

Utilizing Stimuli Responsive Linkages to Engineer and Enhance Polymer Nanoparticle-Based Drug Delivery Platforms

Hershberger

Gauger

Bronstein

2021

ACS Appl. Bio Mater.

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The devastating nature of cancer continues to be one of the leading causes of death in the world. Chemotherapy is among the most common forms of cancer treatment but comes with a host of adverse effects caused by the therapeutic agents damaging healthy tissue and organs. To limit these side effects, scientists have been designing stimuli responsive drug delivery vessels for targeted release. This Review focuses on the incorporation of stimuli responsive linkages in targeted drug delivery systems to enhance therapeutic efficiency. These platforms are primarily employed to control the distribution of anticancer agents in the body to reduce the adverse side effects caused by their toxicities. We will outline how drug delivery vessels are constructed so that exposure to select environmental and external stimuli releases the enclosed drug only at the target site. Stimuli responsive components are integrated within drug delivery vessels in the form of cross-linkers, polymers, and surface modifications. The changes, these moieties undergo upon stimuli exposure, cascade into larger scale alterations to the platforms, resulting in complete disassembly, reversible morphological variations, and enhanced cellular uptake. The ability for these modes of delivery to be initiated exclusively under stimuli exposure allows for release of toxic therapeutic agents to be confined only to the affected area.

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“…Meanwhile, this polymer-protein displayed the characteristics of temperature sensitivity and glutathione (GSH) responsiveness. The encapsulation of doxorubicin (DOX) using the nanoparticles exhibited anti-tumor activities [71,72,73,74].…”

Section: Protein-based Nanoparticles For Drug Deliverymentioning

confidence: 99%

Functional Protein-Based Bioinspired Nanomaterials: From Coupled Proteins, Synthetic Approaches, Nanostructures to Applications

Zhang

Wang

2019

IJMS

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Protein-based bioinspired nanomaterials (PBNs) combines the advantage of the size, shape, and surface chemistry of nanomaterials, the morphology and functions of natural materials, and the physical and chemical properties of various proteins. Recently, there are many exciting developments on biomimetic nanomaterials using proteins for different applications including, tissue engineering, drug delivery, diagnosis and therapy, smart materials and structures, and water collection and separation. Protein-based biomaterials with high biocompatibility and biodegradability could be modified to obtain the healing effects of natural organisms after injury by mimicking the extracellular matrix. For cancer and other diseases that are difficult to cure now, new therapeutic methods involving different kinds of biomaterials are studied. The nanomaterials with surface modification, which can achieve high drug loading, can be used as drug carriers to enhance target and trigger deliveries. For environment protection and the sustainability of the world, protein-based nanomaterials are also applied for water treatment. A wide range of contaminants from natural water source, such as organic dyes, oil substances, and multiple heavy ions, could be absorbed by protein-based nanomaterials. This review summarizes the formation and application of functional PBNs, and the details of their nanostructures, the proteins involved, and the synthetic approaches are addressed.

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Multi-stimuli-responsive biohybrid nanoparticles with cross-linked albumin coronae self-assembled by a polymer-protein biodynamer

Cited by 25 publications

References 57 publications

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Utilizing Stimuli Responsive Linkages to Engineer and Enhance Polymer Nanoparticle-Based Drug Delivery Platforms

Functional Protein-Based Bioinspired Nanomaterials: From Coupled Proteins, Synthetic Approaches, Nanostructures to Applications

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