Multi-shaped cationic gold nanoparticle-l-cysteine-ZnSeS quantum dots hybrid nanozyme as an intrinsic peroxidase mimic for the rapid colorimetric detection of cocaine

Adegoke, Oluwasesan; McKenzie, Craig; Daéid, Niamh Nic

doi:10.1016/j.snb.2019.02.074

Cited by 29 publications

(11 citation statements)

References 54 publications

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“…As shown in Table 2, most of the developed biosensors are able to detect cocaine in trace concentration and in a wide range of sample matrices (mostly biological samples). Recently, sub µM limit of detection has been achieved by using bioderived [55,56,59] or hybrid nanozyme receptors [53]. However, the nanoMIPs used in this work guarantees higher stability against environmental factors that usually affect bioderived receptors (protein, antibodies and aptamers), such as high or low temperatures and enzymatic degradation.…”

Section: Sensor Sensitivity and Specificitymentioning

confidence: 99%

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

et al. 2020

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The development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as the sensing element. The nanoMIPs were first characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering and found to be ~148.35 ± 24.69 nm in size, using TEM. The nanoMIPs were then covalently attached to gold screen-printed electrodes and a cocaine direct binding assay was developed and optimized, using EIS as the sensing principle. EIS was recorded at a potential of 0.12 V over the frequency range from 0.1 Hz to 50 kHz, with a modulation voltage of 10 mV. The nanoMIPs sensor was able to detect cocaine in a linear range between 100 pg mL−1 and 50 ng mL−1 (R2 = 0.984; p-value = 0.00001) and with a limit of detection of 0.24 ng mL−1 (0.70 nM). The sensor showed no cross-reactivity toward morphine and a negligible response toward levamisole after optimizing the sensor surface blocking and assay conditions. The developed sensor has the potential to offer a highly sensitive, portable and cost-effective method for cocaine detection.

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Section: Sensor Sensitivity and Specificitymentioning

confidence: 99%

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

et al. 2020

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“…2). Additionally, some materials, such as quantum dots (QDs), 68 β-cyclodextrin (β-CD), 69 polyoxometalates (POMs), 70 polyvinyl alcohol, 71 hydrogel, 72 cysteamine 73 and tannic acid 74 combined with Au NPs showed higher cata-Fig. 1 Schematic diagram of the nanozyme aptasensor prepared by adapting Au NPs to norovirus aptamer.…”

Section: Au-based Nanozymesmentioning

confidence: 99%

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Chi

Wang

2023

Analyst

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“…The spectra were recorded using a 40x objective, a 1 s accumulation time with a total of 10 accumulations. The synthesis of GSH-ZnS/Ag 2 Se core/shell QDs [16], GO nanosheets [17,18] and CTAB-AuNPs [19] are described in the Electronic Supplementary Material.…”

Section: Characterizationmentioning

confidence: 99%

Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe

et al. 2020

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Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2 Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to form a QD-GO nanocomposite. The binding interaction resulted in a fluorescence turn-ON. Thereafter, cetyltrimethylammonium bromide (CTAB)-gold nanoparticles (AuNPs) were directly adsorbed on the QD-GO nanocomposite to form a novel QD-GO-CTAB-AuNP nanohybrid assembly that resulted in a fluorescence turn-OFF. Streptavidin (strep) was then adsorbed on the QDs-GO-CTAB-AuNP nanohybrid assembly which allowed binding to a biotinylated MNS 4.1 anticocaine DNA aptamer (B) receptor. The addition of cocaine into the strep-B-QDs-GO-CTAB-AuNP aptamer nanoprobe system aided affinity to the aptamer receptor and in turn turned on the fluorescence of the nanoprobe in a concentration-dependent manner. Under optimum experimental conditions, we found the strep-B-QD-GO-CTAB-AuNP to be far superior in its sensitivity to cocaine than the tested strep-B-QDs (no GO and CTAB-AuNPs), strep-B-QD-CTAB-AuNP (no GO) and strep-B-QD-GO (no CTAB-AuNP). In addition, the investigation of localized surface plasmon resonance (LSPR) amplified signal from tested plasmonic NPs shows that CTAB-AuNPs was far superior in amplifying the fluorescence signal of the nanoprobe. A detection limit of 4.6 nM (1.56 ng.mL −1), rapid response time (~2 min) and excellent selectivity against other drugs, substances and cocaine metabolites was achieved. The strep-B-QD-GO-CTAB-AuNP aptamer-based fluorescent nanoprobe was successfully applied for the determination of cocaine in seized adulterated cocaine samples.

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Multi-shaped cationic gold nanoparticle-l-cysteine-ZnSeS quantum dots hybrid nanozyme as an intrinsic peroxidase mimic for the rapid colorimetric detection of cocaine

Abstract: Multi-shaped cationic gold nanoparticle-L-cysteine-ZnSeS quantum dots hybrid nanozyme as an intrinsic peroxidase mimic for the rapid colorimetric detection of cocaine.

Cited by 29 publications

References 54 publications

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe

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