“…Understanding agonist binding of hChem-GPCRs at the molecular level can provide complementary insights on chemical sensing (Charlier et al, 2013 ; Di Pizio and Niv, 2014 ; Suku et al, 2017 ), as well as offer exciting and unexplored opportunities for drug design (Foster et al, 2014 ; Ferrer et al, 2016 ; Shaik et al, 2016 ; Lu et al, 2017 ). In addition, it may provide hints on receptors' agonist binding site architecture (Sandal et al, 2015 ) and activation mechanisms (Lai et al, 2005 , 2014 ; Biarnes et al, 2010 ; Dai et al, 2011 ; Singh et al, 2011a ; Pydi et al, 2014a ; de March et al, 2015b ).…”