Multi-scale nacre-inspired lamella-structured Ti-Ta composites with high strength and low modulus for load-bearing orthopedic and dental applications

Huang, Qianli; Xu, Shenghang; Ouyang, Zhengxiao; Yang, Yan; Liu, Yong

doi:10.1016/j.msec.2020.111458

Cited by 21 publications

(13 citation statements)

References 42 publications

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“…High incidence of bone loss resulting from trauma, infection, or disease is evidenced by more than 2 million bone grafts used in orthopedic procedures annually worldwide [1]. While autologous bone serves as the gold standard for bone defect repair, it is associated with morbidity and pain of the donor site [2].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

et al. 2020

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The high incidence of bone defect cases necessitates a rapid development of cost-effective bone tissue engineering approaches. Bone growth factors such as bone morphogenetic protein-2 (BMP-2) play a vital role in bone tissue engineering. The osteoinductive efficacy of BMP-2 and other osteogenic growth factors is highly dependent on their dose and delivery mode. Slow and sustained delivery of a low dose of BMP-2 promotes bone defect healing. However, the burst release of a high dose of BMP-2 not only fails to promote bone healing but also causes adverse local and systemic effects. The biomimetic calcium phosphate (BioCaP) coating technique guarantees a slow, gradual, and local release of BMP-2 to mimic its natural release from the bone matrix under physiological conditions. Therefore, BioCaP coatings have long been regarded as a promising drug carrier for growth factors. In this mini-review, we give a brief introduction to BioCaP coatings regarding their preparation techniques, physicochemical properties, potential as a drug carrier, ability to suppress foreign body reactivity, and their preclinical application in ectopic and orthotopic models. Finally, the current challenges and future prospects of BioCaP coatings are discussed.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

et al. 2020

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“…Scaffolds designed for orthopedic implantation should have good biocompatibility, osteointegration capacity, and appropriate mechanical properties that facilitate bone ingrowth [ 26 ]. Many attempts have been made to combine the advantages of Ti6Al4V (Ti) and Ta in the same scaffold [ 7 , [27] , [28] , [29] ]. However, as mentioned previously, it remains challenging to obtain both satisfactory mechanical properties and biological activity, regardless of using Ti6Al4V–Ta alloy or Ta coating on Ti6Al4V.…”

Section: Discussionmentioning

confidence: 99%

Porous tantalum structure integrated on Ti6Al4V base by Laser Powder Bed Fusion for enhanced bony-ingrowth implants: In vitro and in vivo validation

Lei

Zhang

et al. 2022

Bioactive Materials

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Despite the widespread application of Ti6Al4V and tantalum (Ta) in orthopedics, bioinertia and high cost limit their further applicability, respectively, and tremendous efforts have been made on the Ti6Al4V-Ta alloy and Ta coating to address these drawbacks. However, the scaffolds obtained are unsatisfactory. In this study, novel high-interface-strength Ti6Al4V-based porous Ta scaffolds were successfully manufactured using Laser Powder Bed Fusion for the first time, in which porous Ta was directly manufactured on a solid Ti6Al4V substrate. Mechanical testing revealed that the novel scaffolds were biomechanically compatible, and the interfacial bonding strength was as high as 447.5 MPa. In vitro biocompatibility assay, using rat bone marrow mesenchymal stem cells (r-BMSCs), indicated that the novel scaffolds were biocompatible. Alkaline phosphatase and mineralized nodule determination demonstrated that the scaffolds favored the osteogenic differentiation of r-BMSCs. Moreover, scaffolds were implanted into rabbits with femur bone defects, and imaging and histological evaluation identified considerable new bone formation and bone ingrowth, suggesting that the scaffolds were well integrated with the host bone. Overall, these results demonstrated good mechanical compatibility, biocompatibility, and osteointegration performance of the novel Ti6Al4V-based porous Ta scaffold, which possesses great potential for orthopedic clinical applications.

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“…The Ti-Ta composite material with bionic structure has high strength, good ductility, low modulus, and good biocompatibility [40] 6 Journal of Nanomaterials sheets, and graphene oxides) are generally made of conductive nanofillers. In multimode sensing, carbon-based materials have attracted much attention due to their strong sensing ability, durability, and low cost [24].…”

Section: Ti-ta Composites Can Be Used In Orthopedic Applicationsmentioning

confidence: 99%

Nanomaterial‐Based Prosthetic Limbs for Disability Mobility Assistance: A Review of Recent Advances

Tan

et al. 2022

Journal of Nanomaterials

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The emergence of new hybrid nanomaterial has enabled prosthetic devices to have more performance and significantly improved the quality of life of the disabled. Due to the biosensing properties of prosthetic limbs made of nanomaterials, a large number of nanocomposites have been designed, developed, and evaluated for various prosthetic limbs, such as e-skin, e-skin’s neurotactility sensing, human prosthetic interface tissue engineering, bones, and biosensors. Nano-based materials are also considered to be the new generation of scientific and technological materials for the preparation of various prosthetic devices for the disabled, which can effectively improve the sense of use of the disabled and achieve functional diversity. The study described various nanomaterials for prosthetic devices, and introduced some basic components of nanocomposites; their applications are in three areas, such as bone, skin, and nerve, and evaluated and summarized the advantages of these applications. The results show that (1) carbon-based nanomaterials as neural materials have been studied most deeply. Due to that strong stability of the carbon-based material and the simple transmission mechanism, the cost can be controlled in manufacturing the artificial limb. Materials with human-computer interaction function are the research focus in the future. (2) Skin nanomaterials are mainly composite materials, generally containing metal- and carbon-based materials. Ionic gels, ionic liquids, hydrogels, and elastomers have become the focus of attention due to the sensitivity, multimodal, and memory properties of their materials. (3) Outstanding nanomaterials for bone are fibrous materials, metallic synthetic materials, and composite materials, with extremely high hardness, weight, and toughness. Of the skeletal materials, the choice of prosthetic socket material is the most important and is typically based on fiber laminate composites. Some of these materials make sensors for durability and performance that can be used for large-scale clinical testing.

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Multi-scale nacre-inspired lamella-structured Ti-Ta composites with high strength and low modulus for load-bearing orthopedic and dental applications

Cited by 21 publications

References 42 publications

Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

Porous tantalum structure integrated on Ti6Al4V base by Laser Powder Bed Fusion for enhanced bony-ingrowth implants: In vitro and in vivo validation

Nanomaterial‐Based Prosthetic Limbs for Disability Mobility Assistance: A Review of Recent Advances

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