Multi-scale models of whole cells: progress and challenges
Konstantia Georgouli,
Jae-Seung Yeom,
Robert C. Blake
et al.
Abstract:Whole-cell modeling is “the ultimate goal” of computational systems biology and “a grand challenge for 21st century” (Tomita, Trends in Biotechnology, 2001, 19(6), 205–10). These complex, highly detailed models account for the activity of every molecule in a cell and serve as comprehensive knowledgebases for the modeled system. Their scope and utility far surpass those of other systems models. In fact, whole-cell models (WCMs) are an amalgam of several types of “system” models. The models are simulated using a… Show more
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