Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels

Comisar, Wendy; Hsiong, Susan X.; Kong, Hyun Joon; Mooney, David J.; Linderman, Jennifer J.

doi:10.1016/j.biomaterials.2005.10.037

Cited by 54 publications

(49 citation statements)

References 32 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dip-pen nanolithography has been proposed as method to directly pattern monolayer into nanometer scaled islands in the range of 30 nm; as such, higher flexibility in nonperiodic patterns can be achieved (Lee et al, 2002). Comisar et al (2006) investigated the effects of RGD nanopatterns, which are independent of bulk density, on cell adhesion and differentiation. While the number of RGD peptides per alginate island was significant for cell spreading and differentiation, the patterns presenting more closely spaced islands favor cell spreading, but only in case of highly spaced islands cell differentiation was observed.…”

Section: The Nanoscale Arrangement Of Ecm Adhesive Peptides Controls mentioning

confidence: 99%

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: The Nanoscale Arrangement Of Ecm Adhesive Peptides Controls mentioning

confidence: 99%

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

et al. 2008

View full text Add to dashboard Cite

show abstract

“…52 The large variable space inherent to adhesion ligand presentation would require massive experimentation to explore in full, but the development of models that can predict the specific range of the relevant variables likely to alter cell receptor binding and clustering promises to focus experiments on the relevant variable ranges. 51,53 While a large number of studies indicate that cell adhesion and phenotype can be regulated in vitro by peptide presentation, the importance of these manipulations to in vivo tissue formation or regeneration is only recently becoming clear. Appropriate adhesion peptide presentation has been shown to regulate bone and cartilage formation by transplanted cells, 48,54 and matching of the degradation rate of the synthetic ECM to the rate of tissue formation in these systems greatly increases the extent and rate of tissue formation.…”

Section: Cell Instructive Polymers Adhesion Ligand Presentationmentioning

confidence: 99%

Regenerative medicine in orthopaedic surgery

Corsi

Schwarz

Mooney

et al. 2007

Journal Orthopaedic Research

Self Cite

View full text Add to dashboard Cite

Regenerative medicine holds great promise for orthopaedic surgery. As surgeons continue to face challenges regarding the healing of diseased or injured musculoskeletal tissues, regenerative medicine aims to develop novel therapies that will replace, repair, or promote tissue regeneration. This review article will provide an overview of the different research areas involved in regenerative medicine, such as stem cells, bioinductive factors, and scaffolds. The potential use of stem cells for orthopaedic tissue engineering will be addressed by presenting the current progress with skeletal muscle-derived stem cells. As well, the development of a revascularized massive allograft will be described and will serve as a prototypic model of orthopaedic tissue engineering. Lastly, we will describe current approaches used to design cell instructive materials and how they can be used to promote and regulate the formation of bony tissue. ß

show abstract

“…The modeling of many biological system requires a multiscale approach: immune system [56], neural systems [57], tumour growth [58], epidermal wound healing [59,60], tissue engineering [61].…”

Section: The Multiscale Problemmentioning

confidence: 99%

Towards a unified approach in the modeling of fibrosis: A review with research perspectives

Amar

Bianca

2016

Physics of Life Reviews

View full text Add to dashboard Cite

Pathological fibrosis is the result of a failure in the wound healing process. The comprehension and the related modeling of the different mechanisms that trigger fibrosis is a challenge of many researchers that work in the field of medicine and biology. The modern scientific analysis of a phenomenon generally consists of three major approaches: theoretical, experimental, and computational. Different theoretical tools coming from mathematics and physics have been proposed for the modeling of the physiological and pathological fibrosis. However a complete framework is missing and the development of a general theory is required. This review aims at finding a unified approach in the modeling of fibrosis diseases that takes into account the different phenomena occurring at each level: molecular, cellular and tissue. Specifically by means of a critical analysis of the different models that have been proposed in the mathematical, computational and physical biology, from molecular to tissue scales, a multiscale approach is proposed, an approach that has been strongly recommended by top level biologists in the past decades.

show abstract

Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels

Cited by 54 publications

References 32 publications

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

Regenerative medicine in orthopaedic surgery

Towards a unified approach in the modeling of fibrosis: A review with research perspectives

Contact Info

Product

Resources

About