Multi-scale mechanical and transport properties of a hydrogel

Salahshoor, Hossein; Rahbar, Nima

doi:10.1016/j.jmbbm.2014.05.028

Cited by 22 publications

(12 citation statements)

References 31 publications

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“…Of the materials used, collagen [ 173 , 174 , 176 , 188 , 199 , 200 , 203 , 213 , 243 ], fibrin [ 175 , 202 , 204 , 246 , 266 ], gelatin [ 182 , 183 , 194 , 267 ], alginate [ 177 , 245 ], and polymers, such as PLLA [ 180 ], PDMS [ 178 , 220 ], or PEG [ 196 , 268 ] generally functionalized or coated with adhesion peptides, are the most commonly found. To compensate for the mechanical weakness of hydrogels and their lack of conductive properties, which are useful in muscle tissue engineering [ 269 , 270 ], nanomaterials have often been added to the initial polymer. These include gold nanostructures [ 265 , 271 ], graphene [ 179 , 195 , 272 ], and carbon nanotubes [ 192 , 194 , 198 , 273 , 274 ].…”

Section: Skeletal Musclementioning

confidence: 99%

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

et al. 2018

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Tissue engineering is a promising approach to repair tendon and muscle when natural healing fails. Biohybrid constructs obtained after cells’ seeding and culture in dedicated scaffolds have indeed been considered as relevant tools for mimicking native tissue, leading to a better integration in vivo. They can also be employed to perform advanced in vitro studies to model the cell differentiation or regeneration processes. In this review, we report and analyze the different solutions proposed in literature, for the reconstruction of tendon, muscle, and the myotendinous junction. They classically rely on the three pillars of tissue engineering, i.e., cells, biomaterials and environment (both chemical and physical stimuli). We have chosen to present biomimetic or bioinspired strategies based on understanding of the native tissue structure/functions/properties of the tissue of interest. For each tissue, we sorted the relevant publications according to an increasing degree of complexity in the materials’ shape or manufacture. We present their biological and mechanical performances, observed in vitro and in vivo when available. Although there is no consensus for a gold standard technique to reconstruct these musculo-skeletal tissues, the reader can find different ways to progress in the field and to understand the recent history in the choice of materials, from collagen to polymer-based matrices.

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Section: Skeletal Musclementioning

confidence: 99%

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

et al. 2018

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“…Salahshoor and Rahbar [67] determined swelling, water diffusion, and stress/strain curves for hydrogels made of PEGDGE cross-linked with polyoxyalkyleneamines at different water contents.…”

Section: Applicationsmentioning

confidence: 99%

From Microscale to Macroscale: Nine Orders of Magnitude for a Comprehensive Modeling of Hydrogels for Controlled Drug Delivery

Casalini

Perale

2019

Gels

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Because of their inherent biocompatibility and tailorable network design, hydrogels meet an increasing interest as biomaterials for the fabrication of controlled drug delivery devices. In this regard, mathematical modeling can highlight release mechanisms and governing phenomena, thus gaining a key role as complementary tool for experimental activity. Starting from the seminal contribution given by Flory–Rehner equation back in 1943 for the determination of matrix structural properties, over more than 70 years, hydrogel modeling has not only taken advantage of new theories and the increasing computational power, but also of the methods offered by computational chemistry, which provide details at the fundamental molecular level. Simulation techniques such as molecular dynamics act as a “computational microscope” and allow for obtaining a new and deeper understanding of the specific interactions between the solute and the polymer, opening new exciting possibilities for an in silico network design at the molecular scale. Moreover, system modeling constitutes an essential step within the “safety by design” paradigm that is becoming one of the new regulatory standard requirements also in the field-controlled release devices. This review aims at providing a summary of the most frequently used modeling approaches (molecular dynamics, coarse-grained models, Brownian dynamics, dissipative particle dynamics, Monte Carlo simulations, and mass conservation equations), which are here classified according to the characteristic length scale. The outcomes and the opportunities of each approach are compared and discussed with selected examples from literature.

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“…71 Thus, coarse-graining not only drastically reduces the number of particles used in simulations, but also allows for larger integration time steps, which in turn enable the simulation of the polymer systems with larger time and length scales. This makes coarse grained molecular dynamics simulations an attractive tool for studying dynamic polymeric systems such as responsive polymer brushes 73,74 and hydrogels [75][76][77][78][79] at scales larger (by approximately ten times) 71 than fully atomistic simulations.…”

Section: Atomistic Modelsmentioning

confidence: 99%

Mesoscale modelling of environmentally responsive hydrogels: emerging applications

Yeh

Alexeev

2015

Chem. Commun.

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Stimuli-sensitive hydrogels are an exciting class of materials with widespread potential for use in engineering and biomedical applications. The design of advanced functional devices using hydrogels requires an in-depth understanding of the physics and behaviour of such materials. While theoretical tools exist, they are often limited to simple cases. Thus, computational methods are necessary to model the complex unsteady physics of hydrogels with high fidelity. Mesoscale modelling is an emerging approach that enables simulations of polymeric structures at length and time scales in between those of molecular dynamics and continuum methods. In this feature article, we review various computational approaches to model responsive hydrogels and specifically focus on dissipative particle dynamics (DPD), a particle-based mesoscale method. We discuss several approaches for modelling cross-linked polymer networks in DPD, and describe recent applications of DPD to modelling hydrogel systems.

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Multi-scale mechanical and transport properties of a hydrogel

Cited by 22 publications

References 31 publications

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges

From Microscale to Macroscale: Nine Orders of Magnitude for a Comprehensive Modeling of Hydrogels for Controlled Drug Delivery

Mesoscale modelling of environmentally responsive hydrogels: emerging applications

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