The paper deals with the analysis of influence of pipe deviations on in-pipe machine locomotion. In-pipe machine locomotes inside a pipe using the friction difference principle of locomotion. Main task of the machine is inspection of inner pipe wall as the prevention of pipe crack and leaks of transported medium. Pipe systems have deviations of inner pipe wall, which are caused by production process and caused by using of pipe (deformations, sediments, changes from coupling of pipes etc.). These pipe deviations have direct influence on machine locomotion inside the pipe.