Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs

Fan, Jingwei; Li, Richen; Wang, Hai; He, Xiuli; Nguyen, Tan Phat; Letteri, Rachel A.; Zou, Jiong; Wooley, Karen L.

doi:10.1039/c7ob00931c

Cited by 34 publications

(21 citation statements)

References 56 publications

(59 reference statements)

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“…Recently, Fan et al . reported a peptide-based hydrogel system [ 62 ]. A polypeptide hydrogel system prepared from ternary sequences of l-alanine, glycine and l-isoleucine within a polypeptide segment of a PEG-peptide diblock structure exhibited thermo-, mechano- and enzyme-responsive properties, which enabled the encapsulation and release of naproxen (Npx) (Fig.…”

Section: Design and Synthesis Of Peptide Assembliesmentioning

confidence: 99%

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

et al. 2021

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Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability. In addition, it has adjustable amino acid structure and sequence, which can be flexible designed and tailored to form supramolecular nano-assemblies with specific biomimicking, recognition, and targeting properties via molecular self-assembly. These unique properties of peptide nano-assemblies made it possible for utilizing them for biomedical and tissue engineering applications. In this review, we summarize recent progress on the motif design, self-assembly synthesis, and functional tailoring of peptide nano-assemblies for both cancer diagnosis and therapy. For this aim, firstly we demonstrate the methodologies on the synthesis of various functional pure and hybrid peptide nano-assemblies, by which the structural and functional tailoring of peptide nano-assemblies are introduced and discussed in detail. Secondly, we present the applications of peptide nano-assemblies for cancer diagnosis applications, including optical and magnetic imaging as well as biosensing of cancer cells. Thirdly, the design of peptide nano-assemblies for enzyme-mediated killing, chemo-therapy, photothermal therapy, and multi-therapy of cancer cells are introduced. Finally, the challenges and perspectives in this promising topic are discussed. This work will be useful for readers to understand the methodologies on peptide design and functional tailoring for highly effective, specific, and targeted diagnosis and therapy of cancers, and at the same time it will promote the development of cancer diagnosis and therapy by linking those knowledges in biological science, nanotechnology, biomedicine, tissue engineering, and analytical science.

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Section: Design and Synthesis Of Peptide Assembliesmentioning

confidence: 99%

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

et al. 2021

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“…The synthesis of well‐defined polypeptide architectures via ROP of N ‐carboxyanhydride (NCA) has received increasing attention during the last decade . Several reports have been published depicting the synthesis of micelles, vesicles, and nanogels by controlled ROP of NCAs . Mechanism of ROP (normal amine mechanism, NAM) (Figure B), involves the attack of a primary amine (nucleophile) to initiate polymerization of NCA leading to the formation of a polypeptide, whose molecular weight can be controlled by regulating NCA to amine ratio.…”

Section: Fabrication Of Redox‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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“…Amongst all types of hydrogels, peptide-based hydrogels have self-assembly ability for hydrogel formation through hydrogen bonding, aromatic (cation-π, π-π), and hydrophobic/hydrophilic interactions [ 12 , 13 , 14 , 15 ]. Additionally, peptide segments can adopt secondary conformations (random coil, β-sheet/β-turn) inside their gel network to enhance the mechanical properties of hydrogels [ 16 , 17 , 18 , 19 , 20 ]. As a type of synthetic hydrogel, polypeptides can modify the characteristics of hydrogels by varying the functional groups on the side chain or the chain composition on the backbone [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Hydrogelation of Star-Shaped Graft Copolypetides with Asymmetric Topology

Phan

Yang

Tsai

et al. 2022

Gels

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To study the self-assembly and hydrogel formation of the star-shaped graft copolypeptides with asymmetric topology, star-shaped poly(L-lysine) with various arm numbers were synthesized by using asymmetric polyglycerol dendrimers (PGDs) as the initiators and 1,1,3,3-tetramethylguanidine (TMG) as an activator for OH groups, followed by deprotection and grafting with indole or phenyl group on the side chain. The packing of the grafting moiety via non-covalent interactions not only facilitated the polypeptide segments to adopt more ordered conformations but also triggered the spontaneous hydrogelation. The hydrogelation ability was found to be correlated with polypeptide composition and topology. The star-shaped polypeptides with asymmetric topology exhibited poorer hydrogelation ability than those with symmetric topology due to the less efficient packing of the grafted moiety. The star-shaped polypeptides grafted with indole group on the side chain exhibited better hydrogelation ability than those grafted with phenyl group with the same arm number. This report demonstrated that the grafted moiety and polypeptide topology possessed the potential ability to modulate the polypeptide hydrogelation and hydrogel characteristics.

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Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs

Cited by 34 publications

References 56 publications

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Synthesis and Hydrogelation of Star-Shaped Graft Copolypetides with Asymmetric Topology

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