Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Abstract

The facile preparation, modular design, and multi‐responsiveness are extremely critical for developing pervasive nanoplatforms to meet heterogeneous applications. Here, cationic nanogels (NGs) are modularly engineered with tunable responsiveness, versatility, and biodegradation. Cationic PVCL‐based NGs with core/shell structure are fabricated by facile one‐step synthesis. The formed PVCL‐NH2 NGs exhibit uniform size, thermal/pH dual‐responsive behaviors, and redox‐triggered degradation. Moreover, the NGs can be employed to modify or/and load with various functional agents to construct multipurpose nanoplatforms in a modular manner. Notably, the novel hybrid structure with copper sulfide (CuS) NPs loaded in the NGs shell is prepared, which leads to higher photothermal conversion efficiency (31.1%) than other CuS randomly loaded NGs reported. By personalized tailoring, these functionalized NGs display fluorescent property, r1 relaxivity, strong near‐infrared (NIR) absorption, good biocompatibility, and targeting specificity. The superior photothermal effect of hybrid NGs (CuS@NGs‐LA) is presented under NIR II over NIR I. Importantly, hybrid NGs encapsulated doxorubicin (CuS@NGs‐LA/DOX) show endogenous pH/redox and exogenous NIR multi‐triggered drug release for efficient photothermal‐chemotherapy, which can completely eliminate advanced tumors and effectively inhibit recurrence. Overall, the pervasive nanoplatforms based on intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed by engineered modular strategy for precision medicine applications.

Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity

“…In order to solve the crisis, antioxidants are capable of quenching reactive free radicals, and thus inhibiting peroxidation and extending the food storage process. Antibacterial and anticancer agents can be used against various infections and diseases as future chemotherapeutic drugs (Xing et al, 2020;Zhong et al, 2020;Li et al, 2021c). Among these bioactive compounds, each of them can be capable of acting as one active agent, but without multiple actions.…”

Zwitterionic Nanogels and Microgels: An Overview on Their Synthesis and Applications

“…Furthermore, various stimuli-responsive functionalities (e.g., glycopeptides) can be instituted judicially into the zwitterionic nanogels to stimulate cells by chemical (e.g., pH) or physical (e.g., ultrasound and light) triggers that have not been extensively explored in the existing literature. [178,179,180] To produce ultrastable antifouling membranes constituted of zwitterionic microgels operating in harsh physical or chemical conditions, such as high temperature and variable pH, and separating heavy metal ions from industrial wastewater, are the future challenges for membrane researchers and engineers. Zwitterionic microgels are very promising materials in terms of membrane application and they should be brought to large-scale uses soon.…”

Injectable Nanocomposite Hydrogels for Cancer Therapy

“…proposed a modular strategy for the synthesis of cationic NHS with tunable responsiveness, versatility, and biodegradability. [ 168 ] The application of this multi‐response cationic nanogel modular platform for accurate diagnosis and treatment is shown in Figure 9 . The addition of materials that respond to different stimuli increased the flexibility of the response, demonstrated excellent design and assembly flexibility, as well as enhanced biomedical performance.…”