Multi-Response Optimization in the Formulation of a Topical Cream from Natural Ingredients

Abstract

Abstract:The aim of this research was to study the effect of local raw materials on the formulation of a base cream formulation and determine the optimum proportion of each material that gives the required properties. Physicochemical properties of cream formulations can be affected by their viscosity, spreadability, and particle size. The quality of the base cream is directly linked to the basic material used in the formulation. Screening of independent factors, namely oil phase (sesame oil, soybean oil, and liquid paraffin), aqueous phase (Aloe vera gel, propylene glycol, and glycerol), and surfactant (soy lecithin, tween, and soy lecithin/tween) was done to choose the best raw material required for the preparation of the base cream. Based on the screening criteria, sesame oil, Aloe vera gel, and soy lecithin were chosen as the best local raw materials. Using a multi-response optimization, the mixing fractions of sesame oil, Aloe vera gel, and soy lecithin were found to be 24%, 28%, and 10%, respectively. This base cream can be used as a suitable matrix for formulation in the cosmetic and pharmaceutical industries.

A Comparison between the Molecularly Imprinted and Non-Molecularly Imprinted Cyclodextrin-Based Nanosponges for the Transdermal Delivery of Melatonin

“…It had a significant role in the administration of the standard dose of formulation to the skin. The topical cream was considered good if the spreadability decreased because the application was easier [ 104 ]. As it can be seen from Table S1 in the Supplementary Materials , there were no considerable differences between the raw cream formulation and βCD:CA MIP-NSs (1:8) cream formulation.…”

A double‐blind, placebo‐controlled randomized trial of skin‐lightening cream containing lycopene and wheat bran extract on melasma

“…The other characterization that is evaluated for skin products such as organoleptic properties, pH, viscosity, spreadability, and stability was desirable. The study by Djiobie Tchienou, GE (2017), stated that spreadability had important role in regulating the effective dosage for topical treatment and cream spreadability between 0.9 and 31.02 (g cm/s) could be considered as suitable spreadability 14 . The spreadability of LWB cream was 14.22 ± 0.11 (g cm/s) which was desirable to apply on the skin.…”

Development and optimization of antioxidant polyherbal cream using artificial neural network aided response surface methodology

“…All prepared formulations were observed for homogeneity and phase separation by visual appearance and touch. The appearance of the cream was judged by its color, opalescence, roughness, and other organoleptic properties were observed [9,10]. The Draize test was used to evaluate skin sensibility.…”

“…where CC is the total height of the cream layer (showing phase separation), and CT is the total height of the emulsion layer (without phase separation) [9]. The creams were evaluated for spreadability, pH, particle size, and viscosity [9,10]. Utilizing the method of Fahimi et al, the creams were tested on Day 1 and 30 days after preparation for microbial growth in tryptone soy agar plates [9].…”