Multi-resistant biofilm-forming pathogens on the International Space Station

Vaishampayan, Ankita; Grohmann, Elisabeth

doi:10.1007/s12038-019-9929-8

Cited by 29 publications

(20 citation statements)

References 26 publications

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“…Interestingly, some investigations have revealed that bacterial growth, biofilm formation, and even virulence can be enhanced under spaceflight conditions [3,[45][46][47]. Several studies have shown that biofilms actually grow and accumulate more in space than on Earth.…”

Section: Biofilm Formation Investigation During Spaceflight Under Assmentioning

confidence: 99%

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Buchovec

Gricajeva

Kalėdienė

et al. 2020

IJMS

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A spacecraft is a confined system that is inhabited by a changing microbial consortium, mostly originating from life-supporting devices, equipment collected in pre-flight conditions, and crewmembers. Continuous monitoring of the spacecraft’s bioburden employing culture-based and molecular methods has shown the prevalence of various taxa, with human skin-associated microorganisms making a substantial contribution to the spacecraft microbiome. Microorganisms in spacecraft can prosper not only in planktonic growth mode but can also form more resilient biofilms that pose a higher risk to crewmembers’ health and the material integrity of the spacecraft’s equipment. Moreover, bacterial biofilms in space conditions are characterized by faster formation and acquisition of resistance to chemical and physical effects than under the same conditions on Earth, making most decontamination methods unsafe. There is currently no reported method available to combat biofilm formation in space effectively and safely. However, antibacterial photodynamic inactivation based on natural photosensitizers, which is reviewed in this work, seems to be a promising method.

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Section: Biofilm Formation Investigation During Spaceflight Under Assmentioning

confidence: 99%

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Buchovec

Gricajeva

Kalėdienė

et al. 2020

IJMS

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“…In addition to mutations in the chromosome, some studies indicated the role of horizontal gene transfer in imparting drug resistance. A report showed that all Gram-positive bacteria were resistant to at least one antibiotic, the most abundant resistant element being the plasmid-borne erythromycin and tetracycline resistance genes that likely spread via horizontal gene transfer from staphylococci ( Sobisch et al., 2019 ; Vaishampayan and Grohmann, 2019 ). Bacillus thuringiensis also exhibited an increased probability of transfer of genetic material (plasmids or chromosome fragments) in spaceflight conditions, which might explain its increased antibiotic resistance and virulence ( Beuls et al., 2009 ; Senatore et al., 2018 ).…”

Section: Application Of Microorganisms In Spacementioning

confidence: 99%

Advances in space microbiology

et al. 2021

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Summary Microbial research in space is being conducted for almost 50 years now. The closed system of the International Space Station (ISS) has acted as a microbial observatory for the past 10 years, conducting research on adaptation and survivability of microorganisms exposed to space conditions. This adaptation can be either beneficial or detrimental to crew members and spacecraft. Therefore, it becomes crucial to identify the impact of two primary stress conditions, namely, radiation and microgravity, on microbial life aboard the ISS. Elucidating the mechanistic basis of microbial adaptation to space conditions aids in the development of countermeasures against their potentially detrimental effects and allows us to harness their biotechnologically important properties. Several microbial processes have been studied, either in spaceflight or using devices that can simulate space conditions. However, at present, research is limited to only a few microorganisms, and extensive research on biotechnologically important microorganisms is required to make long-term space missions self-sustainable.

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“…The latest investigation by Zea et al aimed to characterize biofilm production, grow and gene expression in microgravity on different materials [133], more data on this topic being reviewed in References. [137,138]. The relevance of such research has been signaled when microbial contaminations were reported onboard space stations.…”

Section: Spaceflight Microbial Concerns: From Bacterial Virulence and Antibiotic Susceptibility To Evidence For Microbial Contaminationsmentioning

confidence: 99%

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

et al. 2021

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The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration. Drug stability is of utmost importance for applications in outer space. Instabilities may be radiation-induced or micro-/hypergravity produced. The antimicrobial agents used in space may have diminished effects not only due to the microgravity-induced weakened immune response of astronauts, but also due to the gravity and radiation-altered pathogens. In this context, the paper provides schemes and procedures to find reliable ways of fighting multiple drug resistance acquired by microorganisms. It shows that the role of multipurpose medicines modified at the molecular scale by optical methods in long-term space missions should be considered in more detail. Solutions to maintain drug stability, even in extreme environmental conditions, are also discussed, such as those that would be encountered during long-duration space exploratory missions. While the microgravity conditions may not be avoided in space, the suggested approaches deal with the radiation-induced modifications in humans, bacteria and medicines onboard, which may be fought by novel pharmaceutical formulation strategies along with radioprotective packaging and storage.

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Multi-resistant biofilm-forming pathogens on the International Space Station

Cited by 29 publications

References 26 publications

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Advances in space microbiology

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

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