Multi-residue enantioselective analysis of chiral drugs in freshwater sediments

Eaglesham, A.; Scott, A.G.; Petrie, Bruce

doi:10.1007/s10311-020-01041-6

Cited by 11 publications

(5 citation statements)

References 23 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the considerable contribution by TPs, as well as enantiomeric detection, the stereoselectivity of chiral pollutants during environmental processes needs to be considered in monitoring studies. Eaglesham et al 70 developed a new enantioselective method for analyzing 15 pharmaceuticals in sediment samples. Sample treatment by accelerated solvent extraction and solid phase extraction was followed by a subsequent enantioselective separation.…”

Section: ■ Pharmaceuticals and Hormonesmentioning

confidence: 99%

Water Analysis: Emerging Contaminants and Current Issues

2021

View full text Add to dashboard Cite

Section: ■ Pharmaceuticals and Hormonesmentioning

confidence: 99%

Water Analysis: Emerging Contaminants and Current Issues

2021

View full text Add to dashboard Cite

“…Pairs of enantiomers have identical physicochemical properties but behave and interact differently in chiral environments due to differences in their three-dimensional shape. Consequently, chiral pharmaceuticals can exhibit enantioselectivity in environmental occurrence, fate and toxicity (Eaglesham et al 2020;Kasprzyk-Hordern 2010;Ribeiro et al 2012aRibeiro et al , b, 2013Sanganyado et al 2017;Wong 2006). Pharmaceuticals with two stereogenic centres have two pairs of enantiomers and so on.…”

Section: Chiral Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Analysis, fate and toxicity of chiral non-steroidal anti-inflammatory drugs in wastewaters and the environment: a review

Petrie

Camacho‐Muñoz

2020

Environ Chem Lett

Self Cite

View full text Add to dashboard Cite

Non-steroidal anti-inflammatory drugs (NSAIDs) are found in the aquatic environment globally. Such drugs including naproxen, ibuprofen and ketoprofen are chiral molecules. Enantiomers of those drugs have identical physicochemical properties but can behave and interact differently in chiral environments due to differences in their three-dimensional shape. This results in enantiospecific differences in environmental fate and toxicity, which is often overlooked. Therefore, we review the analytical methods, occurrence and fate, and toxicity of chiral non-steroidal anti-inflammatory drugs at the enantiomeric level. The advancement of enantioselective chromatography methods, particularly the use of polysaccharide-based stationary phases, has enabled trace determination of enantiomers in complex environmental matrices. Macrocosm and microcosm studies of engineered and natural environments revealed that such drugs can undergo both enantioselective degradation and chiral inversion. Enantioselectivity has been reported during wastewater treatment, in surface waters and in agricultural soils. The use of microcosms spiked with individual enantiomers over racemates is essential to evaluate these degradation and inversion fate processes. The chiral inversion process whereby one enantiomer converts into its antipode can be significant if the more toxic enantiomers are formed. Existing enantiospecific effect studies report less than an order of magnitude difference in enantiomer toxicity. However, toxicity data for enantiomers are limited and further research is needed to better appreciate the environmental risk at the enantiomeric level.

show abstract

“…The most common methods for the extraction of ECs from solid environmental matrices, such as suspended solids or sludge, are microwave accelerated extraction (MAE), pressurised liquid extraction (PLE), and ultra-sonic extraction (USE). 1,11,30,38 There is little difference found in the performance and extraction efficiency of the three methods. 36,39,40 MAE and PLE are easier to automatise than USE.…”

Section: Introductionmentioning

confidence: 99%