Multi-residue determination of 115 veterinary drugs and pharmaceutical residues in milk powder, butter, fish tissue and eggs using liquid chromatography–tandem mass spectrometry

Dasenaki, Marilena E.; Thomaidis, Nikolaos S.

doi:10.1016/j.aca.2015.04.013

Cited by 236 publications

(139 citation statements)

References 46 publications

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“…(Bohm et al 2009;Chico et al 2008;Dasenaki and Thomaidis 2015;Freitas et al 2014;Frenich et al 2010;Geis-Asteggiante et al 2012;Granelli and Branzell 2007;Han et al 2015;Hermo et al 2008;Kaufmann et al 2014;Martins-Júnior et al 2007;Mastovska and Lightfield 2008;Ortelli et al 2009;Stolker et al 2008;Turnipseed et al 2014;Wang et al 2015) but there is a lack in the method development for processed dairy products, since antibiotics are not fully degraded during pasteurization process (Pérez et al 2013).…”

Section: Additionally This Technique Fulfills the Requirements Demmentioning

confidence: 99%

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

2017

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In regard to the knowledge of provoking a worldwide resistance against antibiotics due to incorrect application and the resulting uptake of residues via the food chain, the European Union set maximum residue levels (MRLs) for these substances in animal derived products to protect the customers. In respect of these MRLs a multi-class UHPLC-MS/MS multiclass method has been developed for the simultaneous determination of 30 substances from different compound groups (quinolones, macrolides, lincosamides, β-lactams, sulphonamides, diamino-pyrimidine derivates and tetracyclines) in various kinds of dairy products. Since this method should be suitable for routine laboratory use, sample preparation requires an easy and fast approach to ensure high sample throughput. Therefore a sample preparation with C18EC dSPE bulk sorbent as a combination of the easy and quick sample preparation provided by QuEChERS and the clean-up principle of reversed phase SPE was applied. This method was validated for all compounds in all matrices in compliance with the requirements of Commission Decision 2002/657/EC.

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Section: Additionally This Technique Fulfills the Requirements Demmentioning

confidence: 99%

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

2017

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“…The most important are solvent extraction [5,16], liquid-liquid extraction (LLE) [3], solidphase extraction (SPE) [1,2,4,5,11,14,15,17,19], ultrasonic-assisted extraction (UAE) [2], and pressurized liquid extraction (PLE) [6,12]. Furthermore, SPE modifications using molecularly imprinted solid-phase extraction (MISPE) [13,20] and magnetic molecularly imprinted polymer solidphase extraction (MIP-SPE) [18] have also been used as extraction methods.…”

Section: Introductionmentioning

confidence: 99%

“…Tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), and doxycycline (DC) constitute a class of broadspectrum antibacterial drugs that are widely used in agriculture for treating and preventing infectious diseases, or as growth promoters [1,2]. Tetracycline antibiotics are poorly metabolized in animals and unsafe levels of drug residues can therefore be present in foods such as meat, fish, honey, milk, and eggs, as well as in products derived from them [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…The analytical techniques reported in the literature for the monitoring and determination of tetracycline antibiotics and other veterinary drugs in eggs are mostly chromatographic, including high performance liquid chromatography (HPLC) with ultraviolet (UV) [7,[11][12][13], fluorescence [14], or mass spectrometry (MS/MS) [1][2][3][4][15][16][17][18][19][20] detection, and ultrahigh-pressure liquid chromatography-tandem mass spectrometry (UHPL-MS/MS) [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

Pérez-Rodríguez

Pezza

2016

Anal Bioanal Chem

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A simple, rapid, and efficient ultrasound-assisted dispersive liquid-liquid microextraction (US-DLLME) method was developed for extraction of tetracycline residues from egg supplement samples, with subsequent determination by flow injection analysis (FIA) coupled to a liquid waveguide capillary cell (LWCC) and a controlled temperature heating bath. Tetracyclines react with diazotized p-sulfanilic acid, in a slightly alkaline medium, to form azo compounds that can be measured at 435 nm. The reaction sensitivity improved substantially (5.12-fold) using an in-line heating temperature of 45 °C. Multivariate methodology was used to optimize the factors affecting the extraction efficiency, considering the volumes of extraction and disperser solvents, sonication time, extraction time, and centrifugation time. Good linearity in the range 30-600 μg L(-1) was obtained for all the tetracyclines, with regression coefficients (r) higher than 0.9974. The limits of detection ranged from 6.4 to 11.1 μg L(-1), and the recoveries were in the range 85.7-96.4 %, with relative standard deviation lower than 9.8 %. Analyte recovery was improved by approximately 6 % when the microextraction was assisted by ultrasound. The results obtained with the proposed US-DLLME-FIA method were confirmed by a reference HPLC method and showed that the egg supplement samples analyzed were suitable for human consumption.

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“…Antibiotics are generally microbial agents that are used in the treatment of pathogenic microorganisms for health of animals and human. In order to decrease infections in farm animals, antibiotics is used in therapeutic levels (Dasenaki & Thomaidis, 2015). Unfortunately, the therapeutic dosage has been increased because of resistant microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Donut¹,

Çavaş²

2017

Turk. J. Fish. Aquat. Sci.

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Importance of the artificial intelligence in the chemical processes has been increased in the recent studies. Although biosorption is widely studied topic in chemistry, modelling of biosorption data is based on very old equations. However, use of artificial intelligence in the biosorption based studies can give important clues to researchers. For this purpose, the biosorption of tetracycline by using Posidonia oceanica from the Mediterranean Sea was studied in this study. According to classical evaluation, the data were well in line with pseudo-second order kinetic and Langmuir's isotherm. In the artificial neural network modelling, the best back propagation algorithm, optimum number of hidden neuron and optimum training:validation:testing ratio were found as Bayesian Regulation, 16 and 70:10:20, respectively. In conclusion, P. oceanica based marine waste can be used in the development of high performance biosorbents for environmental pollutants. However, it should not be forgotten that P.oceanica is a threatened species; therefore, only dead leaves accumulated in recreational area should be collected and evaluated based on the permissions of governmental authorities. The results also exhibited that artificial neural network can also be used in the modelling of the biosorption data in which it helps scientists to estimate biosorption ratio correctly under various conditions.

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Multi-residue determination of 115 veterinary drugs and pharmaceutical residues in milk powder, butter, fish tissue and eggs using liquid chromatography–tandem mass spectrometry

Cited by 236 publications

References 46 publications

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

Ultrasound-assisted dispersive liquid–liquid microextraction of tetracycline drugs from egg supplements before flow injection analysis coupled to a liquid waveguide capillary cell

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