Multi-residue determination of 10 selected new psychoactive substances in wastewater samples by liquid chromatography–tandem mass spectrometry

Borova, Viola L.; Gago-Ferrero, Pablo; Pistos, Constantinos; Thomaidis, Nikolaos S.

doi:10.1016/j.talanta.2015.06.080

Cited by 67 publications

(49 citation statements)

References 28 publications

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“…Furthermore, their detection by LC–HRMS could be affected by the complexity of the matrix. Thus, targeted, quantitative methods still have value, although they are limited to the target list of compounds included in the scope of the method, with the corresponding reference standards being required for method optimization, data acquisition and quantification …”

Section: Introductionmentioning

confidence: 99%

“…Thus, targeted, quantitative methods still have value, although they are limited to the target list of compounds included in the scope of the method, with the corresponding reference standards being required for method optimization, data acquisition and quantification. [14][15][16][17][18][19] In the forensic context, biological samples may be taken from members of the public for drug testing as part of investigations into traffic offences assaults and other criminal activity. Blood samples are taken routinely in post-mortem examinations.…”

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confidence: 99%

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Investigating the appearance of new psychoactive substances in South Australia using wastewater and forensic data

Bade

Stockham

Painter

et al. 2018

Drug Testing and Analysis

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New psychoactive substances (NPS) have increased in use and popularity worldwide. Wastewater analysis has been successfully applied to evaluate illicit drugs use within a population. However, for NPS, such an approach may be limited due to low doses of NPS combined with their ever-changing composition and usage. The dynamic nature of the NPS market means use may be opportunistic, infrequent, and with few users. Hence, the use of complementary information sources is recommended to improve the knowledge on NPS consumption. The aim of this study was to investigate the changing landscape of NPS use on a community scale by combining wastewater analysis and forensic toxicology. Forensic analysis provided specific information on NPS prevalence in post-mortem blood samples in Adelaide, South Australia over five years, while wastewater analysis showed community use over the same period. A qualitative liquid chromatography--high resolution mass spectrometry method was initially used to screen the wastewater samples. A total of 24 NPS were found: 6 in wastewater only, 13 in forensic post-mortem toxicology samples only, and 5 in both. As these results showed the presence of NPS, a targeted method was subsequently employed to quantify levels of these NPS in wastewater. Temporal trends were found in wastewater with distinct tendencies for synthetic cathinones visible over the period studied.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Investigating the appearance of new psychoactive substances in South Australia using wastewater and forensic data

Bade

Stockham

Painter

et al. 2018

Drug Testing and Analysis

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“…Ez még az olyan szerekre is igaz, mint a mefedron, ami 2007 óta kapható Európában, és 2009-2010-ben rendkívül elterjedtnek számított az Egyesült Királyságban. Kirívóan ártalmasak a két-, három-vagy akár hétféle anyag összekeveréséből született termékek, amelyekből 2013-ban száz-nál is többet azonosítottak Európában (Borova et al [2015] Ort et al [2014] beszámolójából kitűnik, hogy 2011 és 2013 között Amszterdamban, Antwerpenben, Londonban és Zürichben fogyott a legtöbb, naponta és 1000 főre átlagosan 400-850 mg kokain. Egy-egy kiugró (200 és 550 mg közötti) értéket kimutattak Barcelonában, Bázelben, Genfben, Utrechtben és Eindhovenben is.…”

Section: Nemzetközi Kábítószer-fogyasztási Körképunclassified

Multidiszciplináris eljárás a kábítószerfogyasztás mérésére: a szennyvízelemzésen alapuló drogepidemiológia. Nemzetközi vizsgálatok és adatok

Rózsa¹

2017

Statisztika szemle

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“…Since its first application by Zuccato et al in 2004(Zuccato et al, 2005, SBE has been used to monitor use of traditional illicit drugs in many countries in Europe (Andres-Costa et al, 2014;Baker et al, 2014;Berset et al, 2010;Bramness et al, 2015;Kankaanpää et al, 2014;Karolak et al, 2010;Mackulak et al, 2014;Östman et al, 2014;Repice et al, 2013;van Nuijs et al, 2009), North America (Banta-Green et al, 2009;Bartelt-Hunt et al, 2009;Bisceglia et al, 2010;Brewer et al, 2012;Heuett et al, 2015;Loganathan et al, 2009;Metcalfe et al, 2010;Yargeau et al, 2014), East Asia (Du et al, 2015;Khan et al, 2014;Kim et al, 2015;Li et al, 2014), and Australia (Irvine et al, 2011;Lai et al, 2015). Recently, a number of studies have also been performed in Europe and Australia to monitoring NPS abuse using the SBE approach (Baker and Kasprzyk-Hordern, 2011;Borova et al, 2015;Castglioni et al, 2015;Chen et al, 2013;Kankaanpää et al, 2014;Kinyua et al, 2015;Mwenesongole et al, 2013;Reid et al, 2014;Thai et al, 2016;van Nuijs et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of new psychoactive substances in wastewater of major Chinese cities

Gao

et al. 2017

Science of The Total Environment

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New psychoactive substances have become increasingly popular across the globe in recent years, which may cause certain public health issues. In this work, sewage-based epidemiology was applied to examine the use of two synthetic cathinones, mephedrone and methylenedioxypyrovalerone (MDPV), and three piperazines, benzylpiperazine (BZP), trifluoromethylphenylpiperazine (TFMPP), and 1-(3-Chlorophenyl)piperazine (mCPP), across China. Influent wastewater samples were collected from 36 sewage treatment plants (STPs) in 18 major cities that cover all the geographic regions of the country. Effluent samples were also collected from selected STPs to determine removal rates. Mephedrone, TFMPP, and mCPP were below detection limits in all the wastewater samples collected, indicating negligible use of these substances in China. MDPV was detected in wastewater at 13 STPs. However, its loads were <1mg/1000inh/d at most of these STPs, indicating low use of this substance. BZP was detected at all the STPs examined, with loads typically falling within the range of 3-10mg/1000inh/d. No clear geographic pattern in BZP occurrence in wastewater was identified. Since BZP in wastewater may also come from its legal sources, whether widespread occurrence of BZP means widespread abuse is yet to be confirmed. Apparent removal of MDPV by wastewater treatment was low (<25%), whereas removal of BZP was nearly complete (typically>95%).

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Multi-residue determination of 10 selected new psychoactive substances in wastewater samples by liquid chromatography–tandem mass spectrometry

Cited by 67 publications

References 28 publications

Investigating the appearance of new psychoactive substances in South Australia using wastewater and forensic data

Investigating the appearance of new psychoactive substances in South Australia using wastewater and forensic data

Multidiszciplináris eljárás a kábítószerfogyasztás mérésére: a szennyvízelemzésen alapuló drogepidemiológia. Nemzetközi vizsgálatok és adatok

Occurrence of new psychoactive substances in wastewater of major Chinese cities

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