Multi-reaction kinetic modeling for the peroxidase–aldolase cascade synthesis of a D-fagomine precursor

Biocatalysis making waves in organic chemistry

“…This group of enzymes is part of the many enzymes that are involved in alkaloid biosynthesis Chloroperoxidase (CPO) catalysed in situ generation of sensitive aldehydes that then are converted into a precursor of D-fagomine. 136 which have been extensively reviewed. The chemistry is based on imine formation and subsequent Mannich chemistry in the case of the aliphatic substrates and Pictet-Spengler cyclisation in the case of aromatic substrates.…”

Cascade enzymatic synthesis of a statin side chain precursor – the role of reaction engineering in process optimization

“…36 In that manner, a vast variable space can be investigated by performing in silico experiments, different reactor set-ups and process conditions to be explored. 37–39…”

“…36 In that manner, a vast variable space can be investigated by performing in silico experiments, different reactor set-ups and process conditions to be explored. [37][38][39] Statins are a class of medication used for lowering the level of cholesterol in the bloodstream. 40 They work by inhibiting 3hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme involved in the biosynthesis of cholesterol.…”